Abstract
Wir berichten die linguistischen und neuropsychologischen Befunde einer Patientin mit primärer progressiver Aphasie (PPA), deren Erkrankung über eine Zeit von 60 Monaten beobachtet wurde. Die Patientin litt an einer flüssigen Aphasie, aus der sich ein Jargon entwickelte. Weitere Defizite bestanden beim Benennen, Nachsprechen und Schreiben, wogegen das Sprachverständnis relativ unbeeinträchtigt blieb. Mit Bezug auf die aktuellen Kriterien (Gorno-Tempini et al., 2011) kann das Sprachsyndrom als logopenische PPA klassifiziert werden. Darüber hinaus zeigten sich aber über diese Kriterien hinausgehende patholinguistische Auffälligkeiten. Neben einer detaillierten Fallbeschreibung wird in dieser Arbeit auf die diagnostischen Schwierigkeiten der PPA-Klassifikation eingegangen.
We present linguistic and neuropsychological findings of a case of primary progressive aphasia (PPA) which was followed up for more than 60 months. The aphasia was fluent, with prominent impairments of naming, repetition and writing. The patient soon developed jargon. Speech comprehension remained relatively intact. With regard to recent recommendations (Gorno-Tempini et al., 2011) the syndrome was classified as logopenic PPA. However, the overlap between our case and the proposed criteria was limited due to particular features of the observed aphasia case. Problems of the PPA classification are discussed.
Literatur
(2002). Validierung der neuropsychologischen Testbatterie CERAD-NP: eine Multi-Center Studie. Universität Basel: Doktorarbeit.
(2000). Regensburger Wortflüssigkeits-Test. Göttingen: Hogrefe Verlag für Psychologie.
(2003). Acute conduction aphasia: an analysis of 20 cases. Brain and Language, 85, 93 – 108.
(2000). Normal ranges of neuropsychological tests for the diagnosis of Alzheimers disease. Studies in Health Technologies and Informatics, 77, 195 – 199.
(2013). Degenerative jargon aphasia: unusual progression of logopenic/phonological progressive aphasia? Behavioural Neurology, 26, 89 – 93.
(2010). Prediction of pathology in primary progressive language and speech disorders. Neurology, 74, 42 – 49.
(2011). The taxonomy of primary progressive aphasia: it walks and quacks like a duck … but which duck? Neurology, 76, 942 – 943.
(2012). The time course of neurolinguistic and neuropsychological symptoms in three cases of logopenic primary progressive aphasia. Neuropsychologia, 50, 1708 – 1718.
(2002). Bogenhausener Semantikuntersuchung (BOSU). München – Jena: Urban & Fischer Verlag.
(2008). Apraxien. Aktuelle Neurologie, 35, 34 – 48.
(2000). The Boston Diagnostic Aphasia Examination (BDAE-3). Philadelphia: Lippincott.
(2011). Classification of primary progressive aphasia and its variants. Neurology, 76, 1006 – 1014.
(2000). Wechsler Gedächtnistest – Revidierte Fassung. WMS-R. Deutsche Adaptation der revidierten Fassung der Wechsler Memory Scale. Bern: Verlag Hans Huber.
(2014). Longitudinal changes in brains of patients with fluent primary progressive aphasia. Brain and Language, 131, 11 – 19.
(1992). The Pyramids and Palm Trees Test. Bury St. Edmunds: Thames Valley Test Company.
(1983). Aachener Aphasie Test. Göttingen: Hogrefe Verlag für Psychologie.
(1986). Arithmetic skills in patients with unilateral cerebral lesions. Cortex, 22, 611 – 620.
(2010). Loss of word-meaning with spared object semantics in a case of mixed primary progressive aphasia. Brain Language, 113, 96 – 100.
(2012). Charakteristiken der flüssigen und der nicht-flüssigen primär progressiven Aphasie. Zeitschrift für Neuropsychologie, 23, 7 – 18.
(1947). Über den Verfall der Sprache bei der Pickschen Krankheit. Archiv für Psychiatrie und Nervenkrankheiten, 179, 94 – 131.
(2003). Slowly progressive pure dysgraphia with late apraxia of speech: a further variant of the focal cerebral degeneration. Brain and Language, 87, 355 – 360.
(2013). Identification of an atypical variant of logopenic progressive aphasia. Brain and Language, 127, 139 – 144.
(1982). Slowly progressive aphasia without generalized dementia. Annals of Neurology, 11, 592 – 598.
(2001). Primary progressive aphasia. Annals of Neurology, 49, 425 – 432.
(2003). Primary progressive aphasia-a language-based dementia. New England Journal of Medicine, 349, 1535 – 1542.
(2008). Primary progressive aphasia and kindred disorders. In D.Duyckaerts & I. Litvan (Eds.), Handbook of Clinical Neurology (pp. 573 – 587). New York: Elsevier.
(1913). On aphasia due to atrophy of the cerebral convolutions. Brain, 36, 493 – 524.
(1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546 – 1554.
(2001). Jargonagraphia in a case of frontotemporal dementia. Brain and Language, 79, 333 – 339.
(2006). Progressive non-fluent aphasia is not a progressive form of non-fluent (post-stroke) aphasia. Aphasiology, 20, 1018 – 1034.
(1998). Fragmented Words: A Case of Late-stage Progressive Aphasia. Neurocase, 4, 219 – 230.
(1904). Zur Symptomatologie der linksseitigen Schläfenlappenatrophie. Monatsschrift für Psychiatrie und Neurologie, 16, 378 – 388.
(2013). Primary progressive dynamic aphasia and Parkinsonism: Generation, selection and sequencing deficits. Neuropsychologia, 51, 2534 – 2547.
(2009). Neologistic jargon aphasia and agraphia in primary progressive aphasia. Journal of the Neurological Sciences, 277, 155 – 159.
(1909). Die partielle Grosshirnatrophie. Journal für Psychologie und Neurologie, 14, 115 – 130.
(1998). CLOX: an executive clock drawing task. Journal of Neurology, Neurosurgery and Psychiatry, 64, 588 – 594.
(2012). Primary progressive aphasia: a tale of two syndromes and the rest. Neurology, 78, 1670 – 1677.
(1893). Sur un cas de surdite′ verbale pure. Revue de Medicine, 13, 733 – 750.
(2012). Progressive aphasia presenting with deep dyslexia and dysgraphia. Cortex, 48, 1234 – 1239.
(1999). Verbaler lerntest/Nonverbaler Lerntest. Göttingen: Hogrefe.
(2013). Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation. Brain, 136, 3474 – 3488.
(2005). „Deep” language disorders in nonfluent progressive Aphasia: an evaluation of the „summation” account of semantic errors across language production tasks. Cognitive Neuropsychology, 22, 643 – 659.
(1975). The selective impairment of semantic memory. Quarterly journal of experimental psychology, 27, 635 – 657.
(2010). Connected speech production in three variants of primary progressive aphasia. Brain, 133, 2069 – 2088.
