The Effects of Vigilance and Visual Distraction on the P50 Mid-Latency Auditory Evoked Potential
Abstract
Sensory gating function has been investigated through measurement of the P50 evoked potential. However, the susceptibility of auditory P50 sensory gating to attentional modulation remains unclear. We sought to investigate the effects of vigilance (sustaining alertness across multiple recording blocks) and visual distraction (watching a muted movie versus a static fixation cross). We specifically chose a movie as the distracting stimulus because investigators sometimes show muted movies during P50 paradigms and the effects of this method were previously unknown. We recorded evoked potentials in a standard paired-click paradigm from groups watching a movie or static fixation cross; both groups completed four identical blocks of recording. Ratings of fatigue were recorded throughout the experiment. P50 and N100 amplitude showed signs of habituation, although N100’s amplitude reduction was more prominent than P50. P50 suppression did not change over the course of the recording session, despite increasing fatigue ratings. P50 suppression was significantly stronger for the participants who watched a movie during the recording. When comparing P50 gating results across studies, care should be taken to consider differing methodologies.
References
(1982). Neurophysiological evidence for a deficit in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry, 17, 639–654.
(2001). Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: Another indication of abnormal sensory processing? Neuroscience Letters, 306, 132–134.
(2000). Impaired auditory gating and P50 nonsuppression following traumatic brain injury. Journal of Neuropsychiatry and Clinical Neuroscience, 12, 77–85.
(2004). Chapter 8: Attention in Cognitive Neuroscience and Neuropsychology. Boston, MA: Houghton-Mifflin, Co.
(1999). Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating. Biological Psychiatry, 45, 917–922.
(1997). Human P50 suppression is not affected by variations in wakeful alertness. Biological Psychiatry, 41, 891–901.
(2013). Cognitivism, psychology, and neuroscience: Movies as attentional engines. In , Psychocinematics: Exploring cognition at the movies (pp. 53–75). New York, NY: Oxford University Press.
(1999). Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. Journal of Abnormal Psychology, 108, 120–133.
(1993). Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia. Schizophrenia Research, 10, 131–141.
(2000). Human electroencephalography. In , Handbook of Psychophysiology (pp. 27–52). New York, NY: Cambridge University Press.
(2007). A meta-analysis of P50 studies in patients with schizophrenia and relatives: Differences in methodology between research groups. Schizophrenia Research, 97, 137–151.
(2001). A comparison of the different interpair intervals in the conditioning-testing P50 paradigms. International Journal of Psychophysiology, 41, 265–270.
(1986). Midlatency auditory evoked responses: Differential effects of sleep in the brain. Electroencephalography and Clinical Neurophysiology, 65, 383–392.
(1998). P50 abnormalities in schizophrenia: Relationship to clinical and neuropsychological indices of attention. Schizophrenia Research, 33, 157–167.
(1989). The selective attention deficit in schizophrenia: Limited resources or cognitive fatigue? Journal of Nervous and Mental Disorders, 177, 735–738.
(2006). P50 sensory gating in panic disorder. Journal of Psychiatry Research, 40, 535–540.
(2006). Caffeine modulates P50 auditory sensory gating in healthy subjects. European Neuropsychopharmacology, 16, 204–210.
(2011). Relevance of attention in auditory sensory gating paradigms in schizophrenia: A pilot study. Journal of Psychophysiology, 25, 60–66.
(2006). Attentional network task performance in patients with schizophrenia-spectrum disorders: Evidence of a specific deficit. Schizophrenia Research, 88, 169–178.
(1994). Sensory gating deviance in schizophrenia in the context of task related effects. International Journal of Psychophysiology, 18, 1–12.
(1992). Attentional influence on the P50 component of the auditory event-related brain potential. International Journal of Psychophysiology, 12, 197–209.
(1992). P50 suppression is not affected by attentional manipulations. Biological Psychiatry, 31, 365–377.
(2001). Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer’s disease. American Journal of Psychiatry, 158, 1319–1321.
(2007). Habituation of auditory evoked potentials: The dynamics of waveform morphology. The Australian and New Zealand Journal of Audiology, 29, 77–88.
(1990). Sensory gating in normals and schizophrenics: A failure to find strong P50 suppression in normals. Biological Psychiatry, 27, 1216–1226.
(2003). P50 gating is not affected by selective attention. Journal of Psychophysiology, 17, 23–29.
(2004). Comparison of sensory gating to mismatch negativity and self-reported perceptual phenomena in healthy adults. Psychophysiology, 41, 604–621.
(2001). The effect of state on sensory gating: Comparison of waking, REM and non-REM sleep. Clinical Neurophysiology, 112, 1154–1165.
(1993). Within-session changes in sensory gating assessed by P50 evoked potentials in normal subjects. Progress in Neuropsychopharmacology and Biological Psychiatry, 17, 781–791.
(2007). Auditory processing in schizophrenia during the middle latency period (10–50 ms): High-density electrical mapping and source analysis reveal subcortical antecedents to early cortical deficits. Journal Psychiatry and Neuroscience, 32, 339–353.
(2000). Determination of the Geodesic Sensor Nets’ average electrode positions and their 10–10 international equivalents (Technical Note). Eugene, OR: Electrical Geodesics.
(1992). P50 suppression in normal subjects: Influence of stimulus intensity, test repetition, and presentation mode. Journal of Psychophysiology, 6, 47–53.
(1996). Gating of auditory P50 in schizophrenics: Unique effects of clozapine. Biology Psychiatry, 40, 181–188.
(1991). Gating of auditory response in schizophrenia and normal controls: Effects of recording site and stimulation interval on the P50 wave. Schizophrenia Research, 4, 31–40.
(1999). Sensory gating in chronic posttraumatic stress disorder: Reduced auditory P50 suppression in combat veterans. Biological Psychiatry, 46, 1656–1664.
(2008). P50 sensory gating ratios in schizophrenics and controls: A review and data analysis. Psychiatry Research, 158, 226–247.
(2006). Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia. Schizophrenia Bulletin, 32, 692–700.
(1990). The significance of the Speech-Sounds Perception Test for cerebral functions. Archives of Clinical Neuropsychology, 5, 265–272.
(2010). Short-term habituation of auditory evoked potentials and neuromagnetic field components in dependence of the interstimulus interval. Experimental Brain Research, 205, 559–570.
(2003). Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia. American Journal of Psychiatry, 160, 1595–1605.
(2004). Attention: A neuropsychological approach. , editor. Hove: Psychology Press.
(1997). Effects of attentional and stressor manipulations on the P50 gating response. Psychophysiology, 34, 703–711.
(2006). P50 sensitivity to physical and psychological state influences. Psychophysiology, 43, 320–328.
(2010). Attentional modulation of the P50 suppression deficit in recent-onset and chronic schizophrenia. Journal of Abnormal Psychology, 119, 31–39.
