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Published Online:https://doi.org/10.1027//0227-5910.21.4.163

The role of sleep in psychiatric illness in general, and depression and suicidality in particular, is poorly understood and has not been well researched despite the pervasiveness of sleep complaints in these conditions. As an exploratory, hypothesis-generating study, female sexual assault survivors with posttraumatic stress disorder (n = 153) who had enrolled in a nightmare-treatment program were assessed for subjectively determined sleep breathing and sleep movement disorders. Diagnoses of potential disorders were based on clinical practice parameters and research algorithms from the field of sleep disorders medicine. Potential sleep breathing and sleep movement disorders were present in 80% of the participants (n = 123) and included three subgroups: sleep-disordered breathing only (n = 23); sleep movement disorder only (n = 45); and both sleep disorders (n = 55). Based on the HamiltonDepression Rating Scale and Suicide subscale, participants with potential sleep disorders suffered greater depression (Cohen's d = .73-.96; p < .01) and greater suicidality (Cohen's d = .57-.78; p < .05) in comparison to participants without potential sleep disorders. The group with both sleep disorders suffered from the most severe depression and suicidality. A provisional hypothesis is formulated that describes how sleep disorders may exacerbate depression and suicidality through the effects of chronic sleep fragmentation.

References

  • Agargun, MY , Kara, H , Solmaz, M (1997a). Subjective sleep quality and suicidality in patients with major depression. Journal of Psychiatric Research, 31, 377– 81 Crossref MedlineGoogle Scholar

  • Agargun, MY , Kara, H , Solmaz, M (1997b). Sleep disturbances and suicidal behavior in patients with major depression. Journal of Clinical Psychiatry, 58, 249– 51 Crossref MedlineGoogle Scholar

  • Agargun, MY , Cilli, AS , Kara, H , Tarhan, N , Kincir, F , Oz, H (1998a). Repetitive and frightening dreams and suicidal behavior in patients with major depression. Comprehensive Psychiatry, 39, 198– 202 Crossref MedlineGoogle Scholar

  • Agargun, MY , Kara, H (1998b). Recurrent sleep panic, insomnia, and suicidal behavior in patients with panic disorder. Comprehensive Psychiatry, 39, 149– 151 Crossref MedlineGoogle Scholar

  • Aldrich, MS , Brower, KJ , Hall, JM (1999). Sleep-disordered breathing in alcoholics. Alcoholism, Clinical and Experimental Research, 23, 134– 40 Crossref MedlineGoogle Scholar

  • American Psychiatric Association (1987). Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: Author Google Scholar

  • American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington DC: Author Google Scholar

  • American Academy of Sleep Medicine (1997). The international classification of sleep disorders . Rochester MN: Author Google Scholar

  • American Sleep Disorders Association (1997). Practice parameters for the indications for polysomnography and related procedures. Sleep, 20, 406– 422 MedlineGoogle Scholar

  • Ancoli-Israel, S , Martin, J , Jones, DW , Caligiuri, M , Patterson, T , Harris, MJ , Jeste, DV (1999). Sleep disordered breathing and periodic limb movements in sleep in older patients with schizophrenia. Biological Psychiatry, 45, 1426– 1432 Crossref MedlineGoogle Scholar

  • Bagley, C , Bolitho, F , Bertrand, L (1995). Mental health profiles, suicidal behavior, and community sexual assault in 2112 Canadian adolescents. Crisis, 16, 126– 131 LinkGoogle Scholar

  • Banno, K , Delaive, K , Walld, R , Kryger, MH (2000). Restless legs syndrome in 218 patients: associated disorders. Sleep Medicine Reviews, 1, 221– 229 CrossrefGoogle Scholar

  • Bardwell, WA , Berry, CC , Ancoli-Israel, S , Dimsdale, JE (1999). Psychological correlates of sleep apnea. Journal of Psychosomatic Research, 47, 583– 596 Crossref MedlineGoogle Scholar

  • Benca, RM (1996). Sleep in psychiatric disorders. Neurologic Clinics, 14, 739– 764 Crossref MedlineGoogle Scholar

  • Benca, RM , Obermeyer, WH , Thisted, RA , Gillin, JC (1992). Sleep and psychiatric disorders. A meta-analysis. Archives of General Psychiatry, 49, 651– 668 Crossref MedlineGoogle Scholar

  • Berkowitz, HL (1984). Restless legs syndrome disguised as an affective disorder. Psychosomatics, 25, 336– 337 Crossref MedlineGoogle Scholar

  • Buysse, D , Reynolds, C , Monk, T , Berman, S , Kupfer, D (1989). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193– 213 Crossref MedlineGoogle Scholar

  • Chu, J (1999). Trauma and suicide. In D Jacob (Ed.), The Harvard Medical School guide to suicide assessment and intervention (pp. 332-354). San Francisco: Jossey-Bass Google Scholar

  • Davidson, JR , Hughes, DC , George, LK , Blazer, DG (1996). The association of sexual assault and attempted suicide within the community. Archives of General Psychiatry, 53, 550– 555 Crossref MedlineGoogle Scholar

  • Decary, A , Rouleau, I , Montplaisir, J (2000). Cognitive deficits associated with sleep apnea syndrome: A proposed neuro-psychological test battery. Sleep, 23, 369– 381 MedlineGoogle Scholar

  • Dement, WC Wake up America: A national sleep alert, Vol. 1: Executive summary and executive report, report of the National Commission on Sleep Disorders Research . Washington, DC: National Institutes of Health, US Dept of Health and Human Services; January 1993, 1-76 Google Scholar

  • Derderian, SS , Bridenbaugh, RH , Rajagopal, KR (1988). Neuropsychologic symptoms in obstructive sleep apnea improve after treatment with nasal continuous positive airway pressure. Chest, 94, 1023– 1027 Crossref MedlineGoogle Scholar

  • Fawcett, J , Scheftner, W , Fogg, L , Clark, DC , Young, MA , Hedeker, D , Gibbons, R (1990). Time-related predictors of suicide in major affective disorder. American Journal of Psychiatry, 147, 1189– 1194 Crossref MedlineGoogle Scholar

  • Foa, E , Riggs, D , Dancu, C , Rothbaum, B (1993). Reliability and validity of a brief instrument for assessing posttraumatic stress disorder. Journal of Traumatic Stress, 6, 459– 473 CrossrefGoogle Scholar

  • Ford, DE , Kamerow, DB (1989). Epidemiologic study of sleep disturbances and psychiatric disorders. Journal of the American Medical Association, 262, 1479– 1484 Crossref MedlineGoogle Scholar

  • Guilleminault, C , Stoohs, R , Clerk, A , Cetel, M , Maistros, P (1993). A cause of excessive daytime sleepiness: The upper airway resistance syndrome. Chest, 104, 781– 787 Crossref MedlineGoogle Scholar

  • Guilleminault, C , Stoohs, R , Kim, YD , Chervin, R , Black, J , Clerk, A (1995). Upper airway sleep disordered breathing in women. Annals of Internal Medicine, 122, 493– 501 Crossref MedlineGoogle Scholar

  • Hall, RC , Platt, DE , Hall, RC (1999). Suicide risk assessment: a review of risk factors for suicide in 100 patients who made severe suicide attempts. Evaluation of suicide risk in a time of managed care. Psychosomatics, 40, 18– 27 Crossref MedlineGoogle Scholar

  • Hamilton, M (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278– 296 Crossref MedlineGoogle Scholar

  • Jacobs, D (2000). Clinical crossroads: A 52-year-old suicidal man. Journal of the American Medical Association, 283, 2693– 2699 CrossrefGoogle Scholar

  • Jacobs, D (1999). The Harvard Medical School guide to suicide assessment and intervention . San Francisco: Jossey-Bass Google Scholar

  • Kalina, M , Jurek-Pelczarska, J , Koslacz, E , Farnik-Brodzinska, M , Tazbirek, M (1999). The depression level in patients with obstructive sleep apnea syndrome. Wiadomosci Lekarskie, 52, 134– 143 MedlineGoogle Scholar

  • Krakow, B , Germain, A , Tandberg, D , Koss, M , Schrader, R , Hollifield, M , Cheng, D , Edmond, T (2000a). Sleep breathing and sleep movement disorders masquerading as insomnia in sexual assault survivors. Comprehensive Psychiatry, 41, 49– 56 Crossref MedlineGoogle Scholar

  • Krakow, B , Lowry, C , Germain, A , Gaddy, L , Hollifield, M , Koss, M , Tandberg, D , Johnston, L , Melendrez, D (2000b). A retrospective study on improvements in nightmares and posttraumatic stress disorder following treatment for co-morbid sleep-disordered breathing. Journal of Psychosomatic Research, 49, 291– 298 Crossref MedlineGoogle Scholar

  • Krakow, B , Hollifield, M , Schrader, R , Koss, M , Tandberg, D , Lauriello, J , McBride, L , Cheng, D , Edmond, T , Kellner, R (2000c). A controlled study of imagery rehearsal for chronic nightmares in sexual assault survivors with PTSD: a preliminary report. Journal of Traumatic Stress, 13, 589– 609 Crossref MedlineGoogle Scholar

  • Krakow, B , Schrader, R , Tandberg, D , Hollifield, M , Koss, M , Yau, CL , Cheng, D (2001). Nightmare frequency in sexual assault survivors with PTSD. Journal of Anxiety Disorders, in press Google Scholar

  • Krakow, B , Melendrez, D , Pedersen, B , Johnston, L , Hollifield, M , Germain, A , Koss, M , Warner, TD , Tandberg, D , Schrader, R Complex insomnia: Insomnia and sleep-disordered breathing in a consecutive series of crime victims with nightmares and posttraumatic stress disorder. Biological Psychiatry, in press MedlineGoogle Scholar

  • Kupfer, DJ (1999). Pathophysiology and management of insomnia during depression. Annals of Clinical Psychiatry, 11, 267– 276 Crossref MedlineGoogle Scholar

  • Lindeman, S , Henriksson, M , Isometsa, E , Lonnqvist, J (1999). Treatment of mental disorders in seven physicians committing suicide. Crisis, 20, 86– 89 LinkGoogle Scholar

  • Martin, SE , Wraith, PK , Deary, IJ , Douglas, NJ (1997). The effect of nonvisible sleep fragmentation on daytime function. American Journal of Respiratory and Critical Care Medicine, 155, 1596– 1601 Crossref MedlineGoogle Scholar

  • Melendrez, D , Krakow, B , Pedersen, B , Hollifield, M , Johnston, L , Germain, A , Koss, M (2000a). Sleep-disordered breathing in twenty consecutive crime victims presenting for nightmare and insomnia treatment: A preliminary report. Sleep, 23, (Suppl) A257– 258 Google Scholar

  • Melendrez, D , Krakow, B , Johnston, L , Pedersen, B , Chavez-Kennedy, D (2000b). Prevalence of “complex insomnia” insomnia plus sleep-disordered breathing—in crime victims with PTSD. Sleep, 23, (Suppl) A316– 317 Google Scholar

  • Millman, RP , Fogel, BS , McNamara, ME , Carlisle, CC (1989). Depression as a manifestation of obstructive sleep apnea: Reversal with nasal continuous positive airway pressure. Journal of Clinical Psychiatry, 50, 348– 351 MedlineGoogle Scholar

  • Mosko, S , Zetin, M , Glen, S , Garber, D , DeAntonio, M , Sassin, J , McAnich, J , Warren, S (1989). Self reported depressive symptomatology, mood ratings, and treatment outcome in sleep disorders patients. Journal of Clinical Psychology, 45, 51– 60 Crossref MedlineGoogle Scholar

  • Motto, JA (1999). Critical points in the assessment and management of suicide risk. In D Jacob (Ed.), The Harvard Medical School guide to suicide assessment and intervention (pp. 228-229). San Francisco: Jossey-Bass Google Scholar

  • Nofzinger, EA , Buysse, DJ , Reynolds, CF , Kupfer, DJ (1993). Sleep disorders related to another mental disorder (nonsubstance/ primary): A DSM-IV literature review. Journal of Clinical Psychiatry, 54, 244– 255 MedlineGoogle Scholar

  • Paffenbarger, RS , Lee, IM , Leung, R (1994). Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatrica Scandinavica Supplementum, 377, 16– 22 Crossref MedlineGoogle Scholar

  • Ramos Platon, MJ , Espinar Sierra, J (1992). Changes in psychopathological symptoms in sleep apnea patients after treatment with nasal continuous positive airway pressure. International Journal of Neuroscience, 62, 173– 195 Crossref MedlineGoogle Scholar

  • Reite, M (1998). Sleep disorders presenting as psychiatric disorders. Psychiatric Clinics of North America, 21, 591– 607 Crossref MedlineGoogle Scholar

  • Reynolds, CF , Coble, PA , Spiker, DG , Neil, JF , Holzer, BC , Kupfer, DJ (1982). Prevalence of sleep apnea and nocturnal myoclonus in major affective disorders: Clinical and polysomnographic findings. Journal of Nervous and Mental Disease, 170, 565– 567 Crossref MedlineGoogle Scholar

  • Sabo, E , Reynolds, CF , Kupfer, DJ , Berman, SR (1991). Sleep, depression, and suicide. Psychiatry Research, 36, 265– 277 Crossref MedlineGoogle Scholar

  • Stepakoff, S (1998). Effects of sexual victimizations on suicidal ideation and behavior in U. S. college women. Suicide and Life Threatening Behavior, 28, 107– 126 MedlineGoogle Scholar

  • Sullivan, CE , Issa, FG , Berthon-Jones, M , McCauley, VB , Costas, LJ (1984). Home treatment of obstructive sleep apnea with continuous positive airway pressure applied through a nose-mask. Bulletin Europeen de Physiopathologie Respiratoire, 20, 49– 54 MedlineGoogle Scholar

  • Wright, J , White, J (2000). Continuous positive airways pressure for obstructive sleep apnoea. Cochrane Database of Systematic Reviews, 2, CD001106– CD001106 Google Scholar

  • Yantis, MA J (1999). Identifying depression as a symptom of sleep apnea. Journal of Psychosocial Nursing and Mental Health Services, 37, 28– 34 MedlineGoogle Scholar

  • Youakim, JM , Doghramji, K , Schutte, SL (1998). Posttraumatic stress disorder and obstructive sleep apnea. Psychosomatics, 39, 168– 171 Crossref MedlineGoogle Scholar

  • Young, T , Palta, M , Dempsey, J , Skatrud, J , Weber, S , Badr, S (1993). The occurrence of sleep-disordered breathing among middle-aged adults. New England Journal of Medicine, 328, 1230– 1235 Crossref MedlineGoogle Scholar

  • Yu, BH , Ancoli-Israel, S , Dimsdale, JE (1999). Effect of CPAP treatment on mood states in patients with sleep apnea. Journal of Psychiatric Research, 33, 427– 432 Crossref MedlineGoogle Scholar