Plasticity and Reorganization in the Rehabilitation of Stroke
The Constraint-Induced Movement Therapy (CIMT) Example
Abstract
Abstract. This paper outlines some actual developments in the behavioral treatment and rehabilitation of stroke and other brain injuries in post-acute and chronic conditions of brain lesion. It points to a number of processes that demonstrate the enormous plasticity and reorganization capacity of the human brain following brain lesion. It also highlights a series of behavioral and neuroscientific studies that indicate that successful behavioral rehabilitation is paralleled by plastic changes of brain structures and by cortical reorganization and that the amount of such plastic changes is obviously significantly determining the overall outcome of rehabilitation.
References
2008). Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions. Experimental Neurology, 212, 14–28.
(2014). Use it and/or lose it – experience effects on brain remodeling across time after stroke. Frontiers in Human Neuroscience, 8, 379. doi: 10.3389/fnhum.2014.00379
(2016). Maladaptive plasticity induces degradation of fine motor skills in musicians: Apollo’s curse. Zeitschrift für Psychologie, 224, 80–90. doi: 10.1027/2151-2604/a000242
(2004). Development of neuropsychiatric symptoms in poststroke patients: A cross-sectional study. Acta Psychiatrica Scandinavica, 110, 55–63.
(2011). Movement therapy induced neural reorganization and motor recovery in stroke: A review. Journal of Bodywork and Movement Therapies, 15, 528–537.
(2001). Behandlung motorischer Störungen nach Schlaganfall: Die Taubsche Bewegungsinduktionstherapie
([Treatment of motor disorders following stroke. The Constraint-Induced Movement Therapy] . Göttingen, Germany: Hogrefe.2011). Rehabilitation of gait after stroke: A review towards a top-down approach. Journal of Neuroengineering and Rehabilitation, 8, 66. doi: 10.1186/1743-0003-8-66
(2010). Juvenile peer play experience and the development of the orbitofrontal and medial prefrontal cortices. Behavioural Brain Research, 207, 7–13.
(2013). Brain restoration as an emerging field in neurology and neuroscience. Restorative Neurology and Neuroscience, 31, 669–679.
(2013). Promoting neuroplasticity and recovery after stroke: Future directions for rehabilitation clinical trials. Current Opinion in Neurology, 26, 37–42.
(2005). Systematic review of economic evidence on stroke rehabilitation services. International Journal of Technology Assessment in Health Care, 21, 15–21.
(2002). Functional organization of primary somatosensory cortex depends on the focus of attention. NeuroImage, 17, 1451–1458.
(2007). Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke. Journal of Neuroscience, 27, 4101–4109.
(1999). Constraint-induced movement therapy for focal hand dystonia in musicians. Lancet, 353, 42.
(2005). Changing the brain through therapy for musicians’ hand dystonia. Annals of the New York Academy of Sciences, 1060, 335–342. doi: 10.1196/annals.1360.028
(2010). Learning-induced alterations in prefrontal cortical circuitry. Behavioural Brain Bresearch, 214, 91–101.
(2013). Applied behavior analysis. New York, NY: Pearson.
(2013). Stroke, cognitive deficits, and rehabilitation: Still an incomplete picture. International Journal of Stroke, 8, 38–45.
(2012). Sensory feedback prosthesis reduces phantom limb pain: Proof of a principle. Neuroscience Letters, 507, 97–100.
(2004). Strategies for stroke rehabilitation. Lancet Neurology, 3, 528–536.
(2013). New evidence for therapies in stroke rehabilitation. Current Atherosclerosis Reports, 15. doi: 10.1007/s11883-013-0331-y
(1998). Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport, 9, 3571–3575.
(2013). Noninvasive strategies to promote functional recovery after stroke. Neural Plasticity, 2013, 854597. doi: 10.1155/2013/854597
(2015). Atlas of the Global Burden of Stroke (1990–2013): The GBD 2013 Study. Neuroepidemiology, 45, 230–236.
. (2003). Sexual experience leads to long-lasting morphological changes in male rat prefrontal cortex, parietal cortex, and nucleus accumbens neurons. Society for Neuroscience Abstracts, 29, 402.3.
(2013). The neural basis of phantom limb pain. Trends in Cognitive Sciences, 17, 307–308.
(1995). Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature, 375, 482–484.
(2003). Reorganization of remote cortical regions after ischemic brain injury: A potential substrate for stroke recovery. Journal of Neurophysiology, 89, 3205–3214.
(2014). Motor recovery from constraint induced movement therapy is not constrained by extent of tissue damage following stroke. Restorative Neurology and Neuroscience, 32, 755–765.
(2012). Atrophy of spared gray matter tissue predicts poorer motor recovery and rehabilitation response in chronic stroke. Stroke, 43, 453–457.
(1989). Plasticity of synapse structure and pattern in the cerebral cortex. Cerebral Cortex, 7, 391–440.
(2014). Pathways of the past: The imprint of memory. Nature Reviews Neuroscience, 5, 108–120.
(1990). Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. Journal of Neurophysiology, 63, 82–104.
(2011). Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurologica Scandinavica, 123, 147–159.
(2014). Harnessing the power of neuroplasticity for intervention. Frontiers in Human Neuroscience, 8, 377. doi: 10.3389/fnhum.2014.00377
(2011). Searching for factors underlying cerebral plasticity in the normal and injured brain. Journal of Communication Disorders, 44, 503–514.
(2012). Age, experience, injury, and the changing brain. Developmental Psychobiology, 54, 311–325.
(2010). Factors influencing cerebral plasticity in the normal and injured brain. Frontiers in Human Neuroscience, 4, 204. doi: 10.3389/fnhum.2010.00204
(1999). Plasticity in the motor system related to therapy-induced improvement of movement after stroke. Neuroreport, 10, 807–810.
(2004). Environmental influences on cognitive and brain plasticity during aging. Journal of Gerontology: Medical Sciences, 59, 940–957.
(2012). Constrained versus unconstrained intensive language therapy in two individuals with chronic, moderate-to-severe aphasia and apraxia of speech: Behavioral and fmri outcomes. American Journal of Speech-Language Pathology, 21, S65–S87.
(2015). Constraint-induced movement therapy after stroke. Lancet Neurology, 14, 224–234.
(2011). Does sensory transcutaneous electrical stimulation enhance motor recovery following a stroke? A systematic review. Neurorehabilitation and Neural Repair, 25, 799–809.
(2010). Evidence-based therapies for upper extremity dysfunction. Current Opinion in Neurology, 23, 678–682.
(2012). Evidence-Based Methods in Motor Rehabilitation after Stroke. Fortschritte Der Neurologie Psychiatrie, 80, 388–393.
(2013). Neurorehabilitation after stroke: Review of current concepts and future developments. Klinische Neurophysiologie, 44, 223–234.
(2015). How evidence based is the positioning of patients with neurological illness? Deutsches Arzteblatt International, 112, 33–34.
(2000). Treatment-induced cortical reorganization after stroke in humans. Stroke, 31, 1210–1216.
(1998). Motor cortex plasticity during constraint-induced movement therapy in stroke patients. Neuroscience Letters, 250, 5–8.
(2014). Non-invasive brain stimulation in neurorehabilitation: Local and distant effects for motor recovery. Frontiers in Human Neuroscience, 8, 378. doi: 10.3389/fnhum.2014.00378
(2008). Constraint-induced movement therapy can improve hemiparetic progressive multiple sclerosis preliminary findings. Multiple Sclerosis, 14, 992–994.
(2013). Constraint-induced movement therapy for the lower extremities in multiple sclerosis: Case series with 4-year follow-up. Archives of Physical Medicine and Rehabilitation, 94, 753–760.
(2005). Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain. Metabolism Clinical and Experimental, 54, 20–23.
(2003). Metabolic imprinting of choline by its availability during gestation: Implications for memory and attentional processing across the lifespan. Neuroscience and Biobehavioral Reviews, 27, 385–399.
(2013). Soft-wired: How the new science of brain plasticity can change your life. San Francisco, CA: Parnassus Publishing.
(2014). Brain plasticity-based therapeutics. Frontiers in Human Neuroscience, 8, 385. doi: 10.3389/fnhum.2014.00385
(1999). Effects of constraint-induced movement therapy on patients with chronic motor deficits after stroke – A replication. Stroke, 30, 586–592.
(2016). Change in movement-related cortical potentials following constraint-induced movement therapy (CIMT) after stroke. Zeitschrift für Psychologie, 224, 112–124. doi: 10.1027/2151-604/a000245
(2008). FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projections. Experimental Brain Research, 185, 453–460.
(2004). Induction of long-term depression is associated with decreased dendritic length and spine density in layers III and V of sensorimotor neocortex. Synapse, 53, 114–121.
(2015). Heart disease and stroke statistics-2015 update a report from the American Heart Association. Circulation, 131, E29–E322.
. (2012). Prenatal stress produces sexually dimorphic and regionally-specific changes in gene expression in hippocampus and frontal cortex of developing rat offspring. Developmental Neuroscience, 33, 531–538.
(2013).
(Principles of neuroplasticity-based rehabilitation . In M. M. MerzenichM. NahumT. M. VanVleetEds., Changing brains applying brain plasticity to advance and recover human ability (Vol. 207, pp. 141–171). Amsterdam, The Netherlands: Elsevier.2011). Constraint-induced movement therapy for the upper paretic limb in acute or sub-acute stroke: A systematic review. International Journal of Stroke, 6, 425–433.
(2011). Neural bases of recovery after brain injury. Journal of Communication Disorders, 44, 515–520.
(2013). Recovery after brain injury: Mechanisms and principles. Frontiers in Human Neuroscience, 7, 887. doi: 10.3389/fnhum.2013.00887
(1996). Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. Journal of Neuroscience, 16, 785–807.
(1997). Adaptive plasticity in primate motor cortex as a consequence of behavioral experience and neuronal injury. Seminars in Neuroscience, 9, 13–23.
(1996). Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science, 272, 1791–1794.
(2001). Post-stroke depression, antidepressant treatment and rehabilitation results – A case-control study. Cerebrovascular Diseases, 12, 264–271.
(2014). A cross-sectorial analysis of physio and occupational therapy pathways after stroke. Gesundheitswesen, 76, 79–85.
(2008). Aphasia therapy on a neuroscience basis. Aphasiology, 22, 563–599.
(2001). Constraint-induced therapy of chronic aphasia after stroke. Stroke, 32, 1621–1626.
(1928). Degeneration and regeneration of the nervous system. London, UK: Oxford University Press.
(1992). Expansion of the cortical representation of a specific skin field in primary somatosensory cortex by intracortical microstimulation. Cerebral Cortex, 2, 181–196.
(2012). Constraint-induced movement therapy (CIMT): Current perspectives and future directions. Stroke Research and Treatment, 2012, 159391.
(2008). Movement-dependent stroke recovery: A systematic review and meta-analysis of TMS and fMR1 evidence. Neuropsychologia, 46, 3–11.
(2012). Efficacy of constraint-induced movement therapy in patients with hemiparetic progressive multiple sclerosis. Archives of Clinical Neuropsychology, 27, 663–664.
(2014). Diffusion tensor imaging study of the response to constraint-induced movement therapy of children with hemiparetic cerebral palsy and adults with chronic stroke. Archives of Physical Medicine and Rehabilitation, 95, 506–514.
(2004). Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology, 47, 33–46.
(2009). Enrich the environment to empower the brain. Trends in Neurosciences, 32, 233–239.
(2007). Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. Neuroscience, 144, 1160–1168.
(2016). Die Errkankung Schlaganfall
. ([Stroke Disorder] . Retrieved from www.schlaganfall-hilfe.de/der-schlaganfall2012a). Maladaptive plasticity for motor recovery after stroke: Mechanisms and approaches. Neural Plasticity, 2012, 359728. doi: 10.1155/2012/359728
(2012b). Noninvasive brain stimulation for motor recovery after stroke: Mechanisms and future views. Stroke Research and Treatment, 2012, 584727.
(2013). Rehabilitation with poststroke motor recovery: A review with a focus on neural plasticity. Stroke Research and Treatment, 2013, 128641.
(2012). The behavior-analytic origins of constraint-induced movement therapy: An example of behavioral neurorehabilitation. Behavior Analyst, 35, 155–178.
(2013). Constraint-induced movement therapy combined with conventional neurorehabilitation techniques in chronic stroke, patients with plegic hands: A case series. Archives of Physical Medicine and Rehabilitation, 94, 86–94.
(2006). Neocortical kindling is associated with opposing alterations in dendritic morphology in neocortical layer V and striatum from neocortical layer III. Synapse, 59, 1–9.
(2006). Stroke incidence and prevalence in Europe: A review of available data. European Journal of Neurology, 13, 581–598.
(2013).
(Constraint-induced movement therapy: A method for harnessing neuroplasticity to treat motor disorders . In M. M. MerzenichM. NahumT. M. VanVleetEds., Changing Brains Applying Brain Plasticity to Advance and RecoverHuman Ability (Vol. 207, pp. 379–401). Amsterdam, The Netherlands: Elsevier.2016). Plasticity and cortical reorganization associated with pain. Zeitschrift für Psychologie, 224, 71–79. doi: 10.1027/2151-2604/a000241
(1999). Decrease in phantom limb pain associated with prosthesis-induced increased use of an amputation stump in humans. Neuroscience Letters, 272, 131–134.
(2015). Exploring stroke survivor experience of participation in an enriched environment: A qualitative study. Disability and Rehabilitation, 37, 593–600.
(2001). International classification of functioning disability health ICF. Geneva, Switzerland: Author.
. (2016). The atlas of heart disease and stroke. Cardiovascular Disease. Retrieved from http://www.who.int/cardiovascular_diseases/resources/atlas/en/
. (2003). Constraint-induced therapy in stroke: Magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair, 17, 48–57.
(2010). The EXCITE stroke trial comparing early and delayed constraint-induced movement therapy. Stroke, 41, 2309–2315.
(