Omega-3 and vitamin E co-supplementation can improve antioxidant markers in obese/overweight women with polycystic ovary syndrome
Abstract
Abstract.Background: Polycystic ovary syndrome is one of the most important factors in female infertility. Oxidative stress is likely to contribute to increased insulin and androgen production in the ovaries, as well as probably impairing follicle production. Aims: This study aims to determine the complementary effects of omega-3 and vitamin E supplements on certain oxidative stress indices in obese and overweight women with polycystic ovary syndrome. Materials and Methods: This double-blind, randomized clinical trial was performed on polycystic ovary syndrome subjects with BMI > 25. Patients were randomly allocated into two groups to receive either 2 g of omega-3 plus 400 IU of vitamin E, or a placebo, for 8 weeks. At the beginning and the end of the study, total antioxidant capacity, glutathione levels, catalase activity, malondialdehyde concentrations, as well as dietary intake and physical activity were evaluated. Statistical analysis was performed using SPSS. Results: 32 patients in the intervention group and 30 patients in the placebo group completed the study. Co-supplementation of omega-3 and vitamin E significantly increased total antioxidant capacity (mg/dl) (1.15 ± 0.93 vs −0.6 ± 0.72; P < 0.001), catalase activity (IU/L) (1.19 ± 1.06 vs 0.12 ± 0.36; P < 0.001) and glutathione levels (μmol/L) (1.5 ± 1.06 vs 0.23 ± 1.43; P = 0.028). Additionally, a significant reduction of malondialdehyde levels (nmol/L) (−0.34 ± 0.32 vs 0.57 ± 2.20; P = 0.008) was observed, in comparison with placebo. Conclusion: Co-supplementation with omega-3 and vitamin E had beneficial effect on total antioxidant capacity, malondialdehyde concentrations, glutathione levels and catalase activity.
References
1 (2015) Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 21(4), 411–26.
2 (2013) The effect of omega-3 supplementation on androgen profile and menstrual status in women with polycystic ovary syndrome: A randomized clinical trial. Iran J Reprod Med. 11(8), 665.
3 (2010) Insulin and hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 122(1–3), 42–52.
4 (2010) Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation. Fertil Steril. 94(4), 1451–6.
5 (2018) Dietary patterns and attention deficit hyperactivity disorder among Iranian children: A case-control study. J Am Coll Nutr. 1–8.
6 (2017) Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome. J Res Med Sci. 22.
7 (2013) Efficacy of omega-3 in the treatment of polycystic ovary syndrome. J Obstet Gynaecol. 33(3), 289–91.
8 (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 81(1).
9 (2006) Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab. 91(1), 336–40.
10 (2012) Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pac J Clin Nutr. 21(4), 511–8.
11 (2001) Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem. 34(5), 407–13.
12 (2017) Association of prooxidant-antioxidant balance with clinical and laboratory parameters and its relation to different drug regimens in polycystic ovary syndrome women with normal BMI. Indian J Clin Biochem. 32(3), 315–22.
13 (2009) Lipid peroxidation, glutathione, ascorbic acid, vitamin E, antioxidant enzyme and serum homocysteine status in patients with polycystic ovary syndrome. BLM. 1(3), 44–9.
14 (2015) Effect of Omega-3 supplementation on Visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. J Reprod Infertil. 16(4), 212.
15 (2011) The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria. Endokrynol Pol. 62(3), 238–42.
16 (2018) Association of omega-3 fatty acid and epileptic seizure in epileptic patients: A systematic review. Int J Prev Med. 9(1), 36.
17 (2017) The effects of Omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in patients with polycystic ovary syndrome: a randomized, double-blind, Placebo-Controlled Trial. Exp Clin Endocrinol Diabetes. 125(06), 353–9.
18 (2011) PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol. 74(4), 424–33.
19 (2006) Diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature. J Clin Endocrinol Metab. 91(3), 781–5.
20 (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 239(1), 70–6.
21 (2013) Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food. 16(3), 206–10.
22 (1984) [13] Catalase in vitro. In Methods Enzymol (vol. 105, pp. 121–6). Elsevier.
23 (2006) A simple automated procedure for thiol measurement in human serum samples. J Bras Patol Med Lab. 42(5), 345–50.
24 (2007) Association of increased total antioxidant capacity and anovulation in nonobese infertile patients with clomiphene citrate–resistant polycystic ovary syndrome. Fertil Steril. 88(2), 418–24.
25 (2015) Antioxidant properties of high-density lipoproteins are impaired in women with polycystic ovary syndrome. Fertil Steril. 103(5), 1346–54.
26 (2004) Omega-3 fatty acids and inflammation. Curr Atheroscler Rep. 6(6), 461–7.
27 (2008) The effect of supplementation with omega-3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM2. 5. Environ Health Perspect. 116(9), 1237.
28 (2010) Effect of omega-3 fatty acid on oxidative stress in patients on hemodialysis. Iran J Kidney Dis. 4(4), 322.
29 (2001) The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease. Arch Intern Med. 161(18), 2185–92.
30 (2013) Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update. 19(3), 268–88.
31 (2010) Effects of EPA and vitamin E on serum enzymatic antioxidants and peroxidation indices in patients with type II Diabetes mellitus. Iran J Public Health. 39(3), 82–91.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Register for access
- Claim
-
Restore content access
This functionality works only for purchases made as a guest