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Original Communication

Lipid Peroxidation in Nicotinamide-Deficient and Nicotinamide-Supplemented Rats

Published Online:

Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was non-significant.