No significant association between vitamin D and COVID-19: A retrospective study from a northern Italian hospital
Abstract
Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies suggested the involvement of Vitamin-D (VitD) in reducing the risk of COVID-19 infections/severity. However, most of them are based on circumstantial evidences, like the association between latitude-related sunlight exposure and mortality rate, while studies based on patients’ VitD measurements are still scarce. Therefore, we retrospectively analyzed the VitD levels (measured as 25-hydroxyvitamin-D) from a cohort of 347 patients admitted to a northern Italian Hospital as suspected COVID-19s. Of them, 128 were positive (83 males, aged 62.7 ± 14.2 and 45 females, aged 69.3 ± 15.6) and 219 were negative (107 males, aged 62.8 ± 19.5 and 112 females, aged 54.3 ± 20.1). The averaged VitD levels were similar in the two groups: 21.8 ± 16.1 ng/mL and 22.8 ± 14.0 ng/mL for the COVID-19 positive and negative group respectively (p-value: 0.39), as well as the percentage of individuals having VitD levels below 30 ng/mL: 78.9% and 73.5% for the COVID-19 positive and negative group respectively. Because a large portion of patients were below the suggested 30 ng/mL threshold, we can’t exclude that VitD supplementation, restoring normal levels, might be beneficial in reducing the risk of infection.
References
1 . COVID-19 coronavirus pandemic statistics [Internet]. [cited 2020 Sep 29]. Available from: https://www.worldometers.info/coronavirus/.
2 . Prevalence of asymptomatic SARS-CoV-2 Infection: a narrative review. Ann Intern Med. 2020;M20–3012.
3 , COVID-19 and multiorgan response. Curr Probl Cardiol. 2020;100618. https://doi.org/10.1016/j.cpcardiol.2020.100618
4 . Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduct Target Ther. 2020;5(1):233.
5 . Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373–80. https://doi.org/10.1016/j.jiph.2020.06.021
6 Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020;14(4):561–565.
7 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359.
8 . Concerning the vitamin D reference range: Pre-analytical and analytical variability of vitamin D measurement. Biochem Medica. 2017;27(3):1–14.
9 Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evid Based Complement Alternat Med. 2018:5813095. https://doi.org/10.1155/2018/5813095
10 . The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32:1195–8.
11 . COVID-19 fatalities, latitude, sunlight, and vitamin D. Am J Infect Control. 2020;000:19–21.
12 . Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North – supports vitamin D as a factor determining severity. Authors’ reply, Aliment. Pharmacol Ther. 2020;51:1438–9.
13 . Toxicological investigation in blood samples from suspected impaired driving cases in the Milan area: Possible loss of evidence due to late blood sampling. Forensic Sci Int. 2018;288:211–7.
14 . LC-MS/MS method for simultaneous determination of linezolid, meropenem, piperacillin and teicoplanin in human plasma samples. J Pharm Biomed Anal. 2019;169:11–8.
15 Comorbidity and its impact on 1,590 patients with Covid-19 in China: A nationwide analysis. Eur Respir J. 2020;55:1–14.
16 . Holick’s rule and vitamin D from sunlight. J Steroid Biochem Mol Biol. 2010;121:328–30.
17 . Association between solar ultraviolet doses and vitamin D clinical routine data in European mid-latitude population between 2006 and 2018. Photochem Photobiol Sci. 2019;18:2696–706.
18 . Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr. 2020;74:856–9.