Neuropharmacological Interventions and Event File Coding in Gilles de la Tourette Syndrome
Abstract
Abstract. Alterations in the integration of perception and action have been proposed as a core cognitive characteristic of GTS. However, to date it is unknown how neuropharmacological interventions used to treat GTS affect the neural systems related to perception and action integration. Here, we introduce an integrated neuropsychopharmacological perspective to address this question. Specifically, we consider the relevant abnormalities in cortico-striato-thalamo-cortical circuits. Furthermore, we highlight how GTS medication might affect the integration of perception and action in the context of event file coding.
Zusammenfassung. Es gibt gute Belege dafür, dass Veränderungen der Integration von Wahrnehmungs- und Handlungsprozesse kognitive Kernmerkmale bei Patienten mit Tourette Syndrom sind. Die Neuropharmakologie dieser Perzeptions-Handlungsprozesse, insbesondere die Effekte anti-psychotischer Pharmaka, die zur Behandlung des Tourette Syndroms eingesetzt werden, ist jedoch unklar. In dieser Arbeit stellen wir integrierte neuropsychopharmakologische Konzepte von Perzeptions-Handlungsprozesse im Kontext der Theorie des „event file“ unter besonderer Berücksichtigung von Auffälligkeiten in den Basalganglien und kortiko-striato-thalamo-kortikalen-Kreisläufen bei Tourette Patienten vor.
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