Personen mit Demenz – eine besondere Zielgruppe in der Sportwissenschaft
Herausforderungen und Empfehlungen für die Durchführung sportwissenschaftlicher Studien
Abstract
Zusammenfassung. In sportwissenschaftlichen Studien mit Personen mit Demenz ist es wichtig, die Besonderheiten der Zielgruppe zu berücksichtigen. Bisherige Studien weisen diesbezüglich Limitationen auf. Im Projekt Bewegung gegen Demenz wurde aufbauend auf einer Analyse des Forschungsstandes ein entsprechendes Studiendesign erarbeitet und in einer randomisierten kontrollierten Studie mit 319 Personen mit Demenz eingesetzt. Eine umfassende Betrachtung motorischer Tests unterstreicht die Bedeutung von angepassten Verfahren und gibt erste Empfehlungen. Die Überprüfung eines multimodalen Bewegungsprogrammes zeigt keine statistisch signifikanten Zeit*Gruppen-Effekte auf die motorische Leistung und den Gang. Explorative Analysen decken Unterschiede in der motorischen und kognitiven Ausgangsleistung zwischen Positiv-, Neutral- und Negativ-Respondern auf. Zudem erklären motorische und kognitive Leistungsänderungen bis zu 39.4 % der Varianz der Gangänderung. Die Ergebnisse und das erarbeitete Studiendesign bieten eine Grundlage für zukünftige Studien, verweisen aber gleichzeitig auf weiteren Forschungsbedarf. Außerdem unterstreichen die begrenzte Eignung eines standardisierten Bewegungsprogrammes sowie Hinweise auf zugrundeliegende Mechanismen die Bedeutung der Berücksichtigung des Individuums.
Abstract. When investigating the effectiveness of physical activity in individuals with dementia, it is important to consider their specific characteristics; where previous studies showed limitations. Thus, we developed an appropriate study design we then used in a randomized controlled trial with 319 individuals with dementia. A comprehensive analysis of motor assessments highlighted the importance of adapted procedures and provided initial recommendations. We found no statistically significant Time*Group effects of a multimodal exercise program on motor and gait performance. Exploratory analyses revealed differences in baseline performance between positive, neutral, and negative responders. Furthermore, changes in motor and cognitive performance explained up to 39.4 % of the variance in gait changes. Our results and elaborated study design provide a basis for future studies, while simultaneously pointing out the need for further research. Moreover, the limited suitability of standardized exercise and first findings of underlying mechanisms emphasize the importance of considering the individual.
Literatur
2011). Changes in cognition. Neurobiology of Aging, 32 S, 58 – 63. https://doi.org/10.1016/j.neurobiolaging.2011.09.010
(2017). Management of gait changes and fall risk in MCI and dementia. Current Treatment Options in Neurology, 19. https://doi.org/10.1007/s11940-017-0466-1
(2019). World Alzheimer Report 2019: Attitudes to dementia. Zugriff am 11. 11. 2019. Verfügbar unter: https://www.alz.co.uk/research/WorldAlzheimerReport2019.pdf
(2019). 2019 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 15, 321 – 387. https://doi.org/10.1016/j.jalz.2019.01.010
(2009). Supervised exercise to reduce agitation in severely cognitively impaired persons. Journal of the American Medical Directors Association, 10, 271 – 276. https://doi.org/10.1016/j.jamda.2008.12.053
(3). –6. Juli 2019). Cluster Analysis of Motor and Cognitive Skills of Institutionalized Individuals with Dementia: 4 Phenotypes for Developing Individualized Physical Activity Programs. Vortrag anlässlich 24th Annual Congress of the European College of Sports Science (ECSS 2019), Prag, Tschechien.
(2022). Effects of a 16-week multimodal exercise program on physical performance in individuals with dementia: A multicenter randomized controlled trial. Journal of Geriatric Physical Therapy, 45, 3 – 24. https://doi.org/10.1519/JPT.0000000000000308
(2008). Gait analysis in demented subjects. Interests and perspectives. Neuropsychiatric Disease and Treatment, 4, 155 – 160. https://doi.org/10.2147/ndt.s2070
(1989). Measuring balance in the elderly. Preliminary development of an instrument. Physiotherapy Canada, 41, 304 – 311. https://doi.org/10.3138/ptc.41.6.304
(2010). Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dementia and Geriatric Cognitive Disorders, 30, 392 – 402. https://doi.org/10.1159/000321357
(2013). Reliability of six physical performance tests in older people with dementia. Physical Therapy, 93, 69 – 78. https://doi.org/10.2522/ptj.20110164
(2014). Feasibility of a combined aerobic and strength training program and its effects on cognitive and physical function in institutionalized dementia patients. A pilot study. PloS One, 9,
(e97577 . https://doi.org/10.1371/journal.pone.00975772014). The Groningen Meander Walking Test: A dynamic walking test for older adults with dementia. Physical Therapy, 94, 262 – 272. https://doi.org/10.2522/ptj.20130077
(2000). Heterogeneity in dementia: Challenges and opportunities. Alzheimer Disease and Associated Disorders, 14, 60 – 63. https://doi.org/10.1097/00002093-200004000-00002
(1968). A means of assessing maximal oxygen intake. JAMA, 203, 201. https://doi.org/10.1001/jama.1968.03140030033008
(1985). Simple method for measurement of lower extremity muscle strength. The American Journal of Medicine, 78, 77 – 81. https://doi.org/10.1016/0002-9343(85)90465-6
(2018). Physical activity can improve cognition in patients with Alzheimer’s disease. A systematic review and meta-analysis of randomized controlled trials. Clinical Interventions in Aging, 13, 1593 – 1603. https://doi.org/10.2147/CIA.S169565
(1990). Functional reach. A new clinical measure of balance. Journal of Gerontology, 45, M192 – M197. https://doi.org/10.1093/geronj/45.6.M192
(1995). The California Verbal Learning Test: psychometric characteristics and clinical application. Neuropsychology Review, 5, 173 – 201. https://doi.org/10.1007/bf02214761
(2003). The six-minute walk test. Respiratory Care, 48, 783 – 785.
(2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39, 175 – 191. https://doi.org/10.3758/BF03193146
(1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189 – 198. https://doi.org/10.1016/0022-3956(75)90026-6
(2015). Exercise programs for people with dementia. The Cochrane Database of Systematic Reviews, CD006489 https://doi.org/10.1002/14651858.CD006489.pub4
(2016). Psychometric viability of measures of functional performance commonly used for people with dementia. A systematic review of measurement properties. JBI Database of Systematic Reviews and Implementation Reports, 14, 115 – 171. https://doi.org/10.11124/JBISRIR-2016-003064
(1995). Functional balance tests in 76-year-olds in relation to performance, activities of daily living and platform tests. Scandinavian Journal of Rehabilitation Medicine, 27, 231 – 241.
(2018). Evaluating physical activity in dementia. A systematic review of outcomes to inform the development of a core outcome set. Age and Ageing, 47, 34 – 41. https://doi.org/10.1093/ageing/afx135
(2009). The Erlangen Test of Activities of Daily Living: First results on reliability and validity of a short performance test to measure fundamental activities of daily living in dementia patients. International Psychogeriatrics, 21, 103 – 112. https://doi.org/10.1017/S1041610208007710
(1994). Validation and use of performance measures of functioning in a non-disabled older population: MacArthur studies of successful aging. Aging (Milan, Italy), 6, 410 – 419. https://doi.org/10.1007/BF03324272
(1994). A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. Journal of Gerontology, 49 M, 85 – 94. https://doi.org/10.1093/geronj/49.2.M85
(2006). Effectiveness of physical training on motor performance and fall prevention in cognitively impaired older persons: A systematic review. American Journal of Physical Medicine & Rehabilitation, 85, 847 – 857. https://doi.org/10.1097/01.phm.0000228539.99682.32
(2008). Measuring functional performance in persons with dementia. Journal of the American Geriatrics Society, 56, 949 – 950. https://doi.org/10.1111/j.1532-5415.2008.01649.x
(2012). Physical training improves motor performance in people with dementia: A randomized controlled trial. Journal of the American Geriatrics Society, 60, 8 – 15. https://doi.org/10.1111/j.1532-5415.2011.03778.x
(2015). What are the benefits of exercise for Alzheimer’s disease? A systematic review of the past 10 years. Journal of Aging and Physical Activity, 23, 659 – 668. https://doi.org/10.1123/japa.2014-0180
(2014). Dementia and cognitive impairment. Epidemiology, diagnosis, and treatment. Clinics in Geriatric Medicine, 30, 421 – 442. https://doi.org/10.1016/j.cger.2014.04.001
(2010). Individualisierte Medizin – Potenziale und Handlungsbedarf. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 104, 727 – 731. https://doi.org/10.1016/j.zefq.2010.07.041
(1999). A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Research Quarterly for Exercise and Sport, 70, 113 – 119. https://doi.org/10.1080/02701367.1999.10608028
(2010). Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dementia and Geriatric Cognitive Disorders, 29, 109 – 114. https://doi.org/10.1159/000272435
(2017). Effect of pelvic tilt exercise using pressure-based visual biofeedback training on the gait parameter in elderly patients with Alzheimer’s disease. European Geriatric Medicine, 8, 30 – 36. https://doi.org/10.1016/j.eurger.2016.11.001
(2006). Guidelines for clinical applications of spatio-temporal gait analysis in older adults. Aging Clinical and Experimental Research, 18, 174 – 176. https://doi.org/10.1007/BF03327437
(2017).
(Clinical aspects of Alzheimer’s disease . In P. BeartM. RobinsonM. RattrayN. J. Maragakis (Eds.), Neurodegenerative diseases (pp. 31 – 53). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-57193-5_22018). Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia. A systematic review. Journal of Physiotherapy, 64, 4 – 15. https://doi.org/10.1016/j.jphys.2017.12.001
(2017). Dementia prevention, intervention, and care. Lancet (London, England), 390, 2673 – 2734. https://doi.org/10.1016/S0140-6736(17)31363-6
(1965). Functional evaluation: the Barthel index. Maryland State Medical Journal, 14, 61 – 65.
(2014). Impact of ambulatory physiotherapy on motor abilities of elderly subjects with Alzheimer’s disease. Geriatrics & Gerontology International, 14, 167 – 175. https://doi.org/10.1111/ggi.12075
(2019). Relationship between knee extension strength and gait styles in patients with dementia. Medicine, 98,
(e14958 . https://doi.org/10.1097/MD.00000000000149582014). Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: A systematic review. Dementia and Geriatric Cognitive Disorders, 38, 347 – 365. https://doi.org/10.1159/000365388
(2015). Effects of a multicomponent exercise program on spatiotemporal gait parameters, risk of falling and physical activity in dementia patients. Dementia and Geriatric Cognitive Disorders Extra, 5, 350 – 360. https://doi.org/10.1159/000435772
(2013). Efficacy of physical exercise intervention on mobility and physical functioning in older people with dementia: A systematic review. Experimental Gerontology, 48, 85 – 93. https://doi.org/10.1016/j.exger.2012.08.008
(1991). The timed “Up & Go”: A test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39, 142 – 148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
(1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271 – 276. https://doi.org/10.2466/pms.1958.8.3.271
(1992). Trail Making Test: Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory.
(1990). An objective measure of physical function of elderly outpatients. The Physical Performance Test. Journal of the American Geriatrics Society, 38, 1105 – 1112. https://doi.org/10.1111/j.1532-5415.1990.tb01373.x
(2009). Test-retest reliability and minimal detectable change scores for the timed “up & go” test, the six-minute walk test, and gait speed in people with Alzheimer disease. Physical Therapy, 89, 569 – 579. https://doi.org/10.2522/ptj.20080258
(2000). Feasibility and measurement properties of the functional reach and the timed up and go tests in the Canadian study of health and aging. The Journals of Gerontology Series a: Biological Sciences and Medical Sciences, 55 M, 70 – 73. https://doi.org/10.1093/gerona/55.2.M70
(2007). Exercise program for nursing home residents with Alzheimer’s disease: A 1-year randomized, controlled trial. Journal of the American Geriatrics Society, 55, 158 – 165. https://doi.org/10.1111/j.1532-5415.2007.01035.x
(1995). A cross-sectional validation study of the FICSIT common data base static balance measures. Frailty and Injuries: Cooperative Studies of Intervention Techniques. The Journals of Gerontology Series a: Biological Sciences and Medical Sciences, 50 M, 291 – 297. https://doi.org/10.1093/gerona/50A.6.M291
(2011). Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials. Journal of Biomedical Science and Engineering, 4, 734 – 739. https://doi.org/10.4236/jbise.2011.411090
(2010). Alter und Gesundheit: Eine Bestandsaufnahme aus Sicht der Gesundheitsberichterstattung. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 53, 404 – 416. https://doi.org/10.1007/s00103-010-1049-4
(2014). Sensor-derived physical activity parameters can predict future falls in people with dementia. Gerontology, 60, 483 – 492. https://doi.org/10.1159/000363136
(2011). Rollator use adversely impacts on assessment of gait and mobility during geriatric rehabilitation. Journal of Rehabilitation Medicine, 43, 424 – 429. https://doi.org/10.2340/16501977-0791
(2014). Improvements in gait characteristics after intensive resistance and functional training in people with dementia. A randomised controlled trial. BMC Geriatrics, 14. https://doi.org/10.1186/1471-2318-14-73
(1986). The challenge of time. Clock-drawing and cognitive function in the elderly. International Journal of Geriatric Psychiatry, 1, 135 – 140. https://doi.org/10.1002/gps.930010209
(2010). Can balance exercise programmes improve balance and related physical performance measures in people with dementia? A systematic review. European Review of Aging and Physical Activity, 7, 13 – 25. https://doi.org/10.1007/s11556-010-0055-8
(2012). Balance and mobility dysfunction and falls risk in older people with mild to moderate Alzheimer disease. American Journal of Physical Medicine & Rehabilitation, 91, 12 – 23. https://doi.org/10.1097/PHM.0b013e31823caeea
(1986). Performance-Oriented Assessment of Mobility problems in elderly patients. Journal of the American Geriatrics Society, 34, 119 – 126. https://doi.org/10.1111/j.1532-5415.1986.tb05480.x
(2019). Recommendations for assessing motor performance in individuals with dementia. Suggestions of an expert panel – A qualitative approach. European Review of Aging and Physical Activity, 16. https://doi.org/10.1186/s11556-019-0212-7
(2020). Effects of a 16-week multimodal exercise program on gait performance in individuals with dementia: A multicenter randomized controlled trial. BMC Geriatrics, 20, 245. https://doi.org/10.1186/s12877-020-01635-3
(2019). Recommended motor assessments based on psychometric properties in individuals with dementia. A systematic review. European Review of Aging and Physical Activity, 16. https://doi.org/10.1186/s11556-019-0228-z
(2017). Effectiveness of a 16-week multimodal exercise program on individuals with dementia. Study protocol for a multicenter randomized controlled trial. JMIR Research Protocols, 6,
(e35 . https://doi.org/10.2196/resprot.67922007). Validity and reliability of quantitative gait analysis in geriatric patients with and without dementia. Journal of the American Geriatrics Society, 55, 632 – 634. https://doi.org/10.1111/j.1532-5415.2007.01130.x
(2014). Effectiveness and cost-effectiveness of the pharmacological treatment of Alzheimer’s disease and vascular dementia. Journal of Alzheimer’s Disease: JAD, 42 S, 19 – 25. https://doi.org/10.3233/JAD-132639
(2006). Bewegung, körperliche und geistige Mobilität im Alter. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 49, 558 – 566. https://doi.org/10.1007/s00103-006-1269-9
(2019).
(Neurodegenerative diseases and ageing . In J. R. HarrisV. I. Korolchuk (Eds.), Biochemistry and cell biology of ageing. Part II clinical science (pp. 75 – 106). Singapore: Springer. https://doi.org/10.1007/978-981-13-3681-2_42012). The neuropsychological profile of Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 2. https://doi.org/10.1101/cshperspect.a006171
(2018). Development and validation of a novel motor-cognitive assessment strategy of compensatory sit-to-stand maneuvers in people with dementia. Journal of Geriatric Physical Therapy, 41, 143 – 154. https://doi.org/10.1519/JPT.0000000000000116
(Hrsg.). (2022). Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. 10. Revision, German Modification, Version 2022. Verfügbar unter: https://www.dimdi.de/static/de/klassifikationen/icd/icd-10-gm/kode-suche/htmlgm2022/block-f00-f09.htm
(2004). Memory span on the Wechsler Scales. Journal of Clinical and Experimental Neuropsychology, 26, 539 – 549. https://doi.org/10.1080/13803390490496605
(2016). Validation of a computerized, game-based assessment strategy to measure training effects on motor-cognitive functions in people with dementia. JMIR Serious Games, 4,
(e12 . https://doi.org/10.2196/games.5696