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Personen mit Demenz – eine besondere Zielgruppe in der Sportwissenschaft

Herausforderungen und Empfehlungen für die Durchführung sportwissenschaftlicher Studien

Published Online:https://doi.org/10.1026/1612-5010/a000352

Zusammenfassung. In sportwissenschaftlichen Studien mit Personen mit Demenz ist es wichtig, die Besonderheiten der Zielgruppe zu berücksichtigen. Bisherige Studien weisen diesbezüglich Limitationen auf. Im Projekt Bewegung gegen Demenz wurde aufbauend auf einer Analyse des Forschungsstandes ein entsprechendes Studiendesign erarbeitet und in einer randomisierten kontrollierten Studie mit 319 Personen mit Demenz eingesetzt. Eine umfassende Betrachtung motorischer Tests unterstreicht die Bedeutung von angepassten Verfahren und gibt erste Empfehlungen. Die Überprüfung eines multimodalen Bewegungsprogrammes zeigt keine statistisch signifikanten Zeit*Gruppen-Effekte auf die motorische Leistung und den Gang. Explorative Analysen decken Unterschiede in der motorischen und kognitiven Ausgangsleistung zwischen Positiv-‍, Neutral- und Negativ-Respondern auf. Zudem erklären motorische und kognitive Leistungsänderungen bis zu 39.4 % der Varianz der Gangänderung. Die Ergebnisse und das erarbeitete Studiendesign bieten eine Grundlage für zukünftige Studien, verweisen aber gleichzeitig auf weiteren Forschungsbedarf. Außerdem unterstreichen die begrenzte Eignung eines standardisierten Bewegungsprogrammes sowie Hinweise auf zugrundeliegende Mechanismen die Bedeutung der Berücksichtigung des Individuums.


Individuals with Dementia – A Special Target Group in Sports Science: Challenges and Recommendations for Future Studies

Abstract. When investigating the effectiveness of physical activity in individuals with dementia, it is important to consider their specific characteristics; where previous studies showed limitations. Thus, we developed an appropriate study design we then used in a randomized controlled trial with 319 individuals with dementia. A comprehensive analysis of motor assessments highlighted the importance of adapted procedures and provided initial recommendations. We found no statistically significant Time*Group effects of a multimodal exercise program on motor and gait performance. Exploratory analyses revealed differences in baseline performance between positive, neutral, and negative responders. Furthermore, changes in motor and cognitive performance explained up to 39.4 % of the variance in gait changes. Our results and elaborated study design provide a basis for future studies, while simultaneously pointing out the need for further research. Moreover, the limited suitability of standardized exercise and first findings of underlying mechanisms emphasize the importance of considering the individual.

Literatur

  • Albert, M. S. (2011). Changes in cognition. Neurobiology of Aging, 32 S, 58 – 63. https://doi.org/10.1016/j.neurobiolaging.2011.09.010 First citation in articleCrossrefGoogle Scholar

  • Allali, G. & Verghese, J. (2017). Management of gait changes and fall risk in MCI and dementia. Current Treatment Options in Neurology, 19. https://doi.org/10.1007/s11940-017-0466-1 First citation in articleCrossrefGoogle Scholar

  • Alzheimer’s Disease International. (2019). World Alzheimer Report 2019: Attitudes to dementia. Zugriff am 11. 11. 2019. Verfügbar unter: https://www.alz.co.uk/research/WorldAlzheimerReport2019.pdf First citation in articleGoogle Scholar

  • Alzheimer‘s Association. (2019). 2019 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 15, 321 – 387. https://doi.org/10.1016/j.jalz.2019.01.010 First citation in articleCrossrefGoogle Scholar

  • Aman, E. & Thomas, D. R. (2009). Supervised exercise to reduce agitation in severely cognitively impaired persons. Journal of the American Medical Directors Association, 10, 271 – 276. https://doi.org/10.1016/j.jamda.2008.12.053 First citation in articleCrossrefGoogle Scholar

  • Barisch-Fritz, B., Bezold, J., Trautwein, S., Scharpf, A. & Woll, A. (3). –6. Juli 2019). Cluster Analysis of Motor and Cognitive Skills of Institutionalized Individuals with Dementia: 4 Phenotypes for Developing Individualized Physical Activity Programs. Vortrag anlässlich 24th Annual Congress of the European College of Sports Science (ECSS 2019), Prag, Tschechien. First citation in articleGoogle Scholar

  • Barisch-Fritz, B., Trautwein, S., Scharpf, A., Krell-Roesch, J. & Woll, A. (2022). Effects of a 16-week multimodal exercise program on physical performance in individuals with dementia: A multicenter randomized controlled trial. Journal of Geriatric Physical Therapy, 45, 3 – 24. https://doi.org/10.1519/JPT.0000000000000308 First citation in articleCrossrefGoogle Scholar

  • Beauchet, O., Allali, G., Berrut, G., Hommet, C., Dubost, V. & Assal, F. (2008). Gait analysis in demented subjects. Interests and perspectives. Neuropsychiatric Disease and Treatment, 4, 155 – 160. https://doi.org/10.2147/ndt.s2070 First citation in articleCrossrefGoogle Scholar

  • Berg, K. (1989). Measuring balance in the elderly. Preliminary development of an instrument. Physiotherapy Canada, 41, 304 – 311. https://doi.org/10.3138/ptc.41.6.304 First citation in articleCrossrefGoogle Scholar

  • Blankevoort, C. G., van Heuvelen, M. J. G., Boersma, F., Luning, H., Jong, J. de & Scherder, E. J. A. (2010). Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dementia and Geriatric Cognitive Disorders, 30, 392 – 402. https://doi.org/10.1159/000321357 First citation in articleCrossrefGoogle Scholar

  • Blankevoort, C. G., van Heuvelen, M. J. G. & Scherder, E. J. A. (2013). Reliability of six physical performance tests in older people with dementia. Physical Therapy, 93, 69 – 78. https://doi.org/10.2522/ptj.20110164 First citation in articleCrossrefGoogle Scholar

  • Bossers, W. J. R., Scherder, E. J. A., Boersma, F., Hortobágyi, T., van der Woude, L. H. V. & van Heuvelen, M. J. G. (2014). Feasibility of a combined aerobic and strength training program and its effects on cognitive and physical function in institutionalized dementia patients. A pilot study. PloS One, 9, e97577. https://doi.org/10.1371/journal.pone.0097577 First citation in articleCrossrefGoogle Scholar

  • Bossers, W. J. R., van der Woude, L. H. V., Boersma, F., Scherder, E. J. A. & van Heuvelen, M. J. G. (2014). The Groningen Meander Walking Test: A dynamic walking test for older adults with dementia. Physical Therapy, 94, 262 – 272. https://doi.org/10.2522/ptj.20130077 First citation in articleCrossrefGoogle Scholar

  • Cohen-Mansfield, J. (2000). Heterogeneity in dementia: Challenges and opportunities. Alzheimer Disease and Associated Disorders, 14, 60 – 63. https://doi.org/10.1097/00002093-200004000-00002 First citation in articleCrossrefGoogle Scholar

  • Cooper, K. H. (1968). A means of assessing maximal oxygen intake. JAMA, 203, 201. https://doi.org/10.1001/jama.1968.03140030033008 First citation in articleGoogle Scholar

  • Csuka, M. & McCarty, D. J. (1985). Simple method for measurement of lower extremity muscle strength. The American Journal of Medicine, 78, 77 – 81. https://doi.org/10.1016/0002-9343(85)90465-6 First citation in articleCrossrefGoogle Scholar

  • Du, Z., Li, Y., Li, J., Zhou, C., Li, F. & Yang, X. (2018). Physical activity can improve cognition in patients with Alzheimer’s disease. A systematic review and meta-analysis of randomized controlled trials. Clinical Interventions in Aging, 13, 1593 – 1603. https://doi.org/10.2147/CIA.S169565 First citation in articleCrossrefGoogle Scholar

  • Duncan, P. W., Weiner, D. K., Chandler, J. & Studenski, S. A. (1990). Functional reach. A new clinical measure of balance. Journal of Gerontology, 45, M192 – M197. https://doi.org/10.1093/geronj/45.6.M192 First citation in articleCrossrefGoogle Scholar

  • Elwood, R. W. (1995). The California Verbal Learning Test: psychometric characteristics and clinical application. Neuropsychology Review, 5, 173 – 201. https://doi.org/10.1007/bf02214761 First citation in articleCrossrefGoogle Scholar

  • Enright, P. L. (2003). The six-minute walk test. Respiratory Care, 48, 783 – 785. First citation in articleGoogle Scholar

  • Faul, F., Erdfelder, E., Lang, A.–G. & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39, 175 – 191. https://doi.org/10.3758/BF03193146 First citation in articleCrossrefGoogle Scholar

  • Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189 – 198. https://doi.org/10.1016/0022-3956(75)90026-6 First citation in articleCrossrefGoogle Scholar

  • Forbes, D., Forbes, S. C., Blake, C. M., Thiessen, E. J. & Forbes, S. (2015). Exercise programs for people with dementia. The Cochrane Database of Systematic Reviews, CD006489 https://doi.org/10.1002/14651858.CD006489.pub4 First citation in articleCrossrefGoogle Scholar

  • Fox, B., Henwood, T., Keogh, J. & Neville, C. (2016). Psychometric viability of measures of functional performance commonly used for people with dementia. A systematic review of measurement properties. JBI Database of Systematic Reviews and Implementation Reports, 14, 115 – 171. https://doi.org/10.11124/JBISRIR-2016-003064 First citation in articleCrossrefGoogle Scholar

  • Frändin, K., Sonn, U., Svantesson, U. & Grimby, G. (1995). Functional balance tests in 76-year-olds in relation to performance, activities of daily living and platform tests. Scandinavian Journal of Rehabilitation Medicine, 27, 231 – 241. First citation in articleGoogle Scholar

  • Gonçalves, A.–C., Cruz, J., Marques, A., Demain, S. & Samuel, D. (2018). Evaluating physical activity in dementia. A systematic review of outcomes to inform the development of a core outcome set. Age and Ageing, 47, 34 – 41. https://doi.org/10.1093/ageing/afx135 First citation in articleCrossrefGoogle Scholar

  • Graessel, E., Viegas, R., Stemmer, R., Kuchly, B., Kornhuber, J. & Donath, C. (2009). The Erlangen Test of Activities of Daily Living: First results on reliability and validity of a short performance test to measure fundamental activities of daily living in dementia patients. International Psychogeriatrics, 21, 103 – 112. https://doi.org/10.1017/S1041610208007710 First citation in articleCrossrefGoogle Scholar

  • Guralnik, J. M., Seeman, T. E., Tinetti, M. E., Nevitt, M. C. & Berkman, L. F. (1994). Validation and use of performance measures of functioning in a non-disabled older population: MacArthur studies of successful aging. Aging (Milan, Italy), 6, 410 – 419. https://doi.org/10.1007/BF03324272 First citation in articleGoogle Scholar

  • Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G. et al. (1994). A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. Journal of Gerontology, 49 M, 85 – 94. https://doi.org/10.1093/geronj/49.2.M85 First citation in articleCrossrefGoogle Scholar

  • Hauer, K., Becker, C., Lindemann, U. & Beyer, N. (2006). Effectiveness of physical training on motor performance and fall prevention in cognitively impaired older persons: A systematic review. American Journal of Physical Medicine & Rehabilitation, 85, 847 – 857. https://doi.org/10.1097/01.phm.0000228539.99682.32 First citation in articleCrossrefGoogle Scholar

  • Hauer, K. & Oster, P. (2008). Measuring functional performance in persons with dementia. Journal of the American Geriatrics Society, 56, 949 – 950. https://doi.org/10.1111/j.1532-5415.2008.01649.x First citation in articleCrossrefGoogle Scholar

  • Hauer, K., Schwenk, M., Zieschang, T., Essig, M., Becker, C. & Oster, P. (2012). Physical training improves motor performance in people with dementia: A randomized controlled trial. Journal of the American Geriatrics Society, 60, 8 – 15. https://doi.org/10.1111/j.1532-5415.2011.03778.x First citation in articleCrossrefGoogle Scholar

  • Hernández, S. S. S., Sandreschi, P. F., da Silva, F. C., Arancibia, B. A. V., da Silva, R., Gutierres, P. J. B. et al. (2015). What are the benefits of exercise for Alzheimer’s disease? A systematic review of the past 10 years. Journal of Aging and Physical Activity, 23, 659 – 668. https://doi.org/10.1123/japa.2014-0180 First citation in articleCrossrefGoogle Scholar

  • Hugo, J. & Ganguli, M. (2014). Dementia and cognitive impairment. Epidemiology, diagnosis, and treatment. Clinics in Geriatric Medicine, 30, 421 – 442. https://doi.org/10.1016/j.cger.2014.04.001 First citation in articleCrossrefGoogle Scholar

  • Hüsing, B. (2010). Individualisierte Medizin – Potenziale und Handlungsbedarf. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 104, 727 – 731. https://doi.org/10.1016/j.zefq.2010.07.041 First citation in articleCrossrefGoogle Scholar

  • Jones, C. J., Rikli, R. E. & Beam, W. C. (1999). A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Research Quarterly for Exercise and Sport, 70, 113 – 119. https://doi.org/10.1080/02701367.1999.10608028 First citation in articleCrossrefGoogle Scholar

  • Kemoun, G., Thibaud, M., Roumagne, N., Carette, P., Albinet, C., Toussaint, L. et al. (2010). Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dementia and Geriatric Cognitive Disorders, 29, 109 – 114. https://doi.org/10.1159/000272435 First citation in articleCrossrefGoogle Scholar

  • Kim, J.–S., Kang, M.–H., Moon, D.–C. & Oh, J.–S. (2017). Effect of pelvic tilt exercise using pressure-based visual biofeedback training on the gait parameter in elderly patients with Alzheimer’s disease. European Geriatric Medicine, 8, 30 – 36. https://doi.org/10.1016/j.eurger.2016.11.001 First citation in articleCrossrefGoogle Scholar

  • Kressig, R. W. & Beauchet, O. (2006). Guidelines for clinical applications of spatio-temporal gait analysis in older adults. Aging Clinical and Experimental Research, 18, 174 – 176. https://doi.org/10.1007/BF03327437 First citation in articleCrossrefGoogle Scholar

  • Kumfor, F., Halliday, G. M. & Piguet, O. (2017). Clinical aspects of Alzheimer’s disease. In P. BeartM. RobinsonM. RattrayN. J. Maragakis (Eds.), Neurodegenerative diseases (pp. 31 – 53). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-57193-5_2 First citation in articleCrossrefGoogle Scholar

  • Lam, F. M. H., Huang, M.–Z., Liao, L.–R., Chung, R. C. K., Kwok, T. C. Y. & Pang, M. Y. C. (2018). Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia. A systematic review. Journal of Physiotherapy, 64, 4 – 15. https://doi.org/10.1016/j.jphys.2017.12.001 First citation in articleCrossrefGoogle Scholar

  • Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D. et al. (2017). Dementia prevention, intervention, and care. Lancet (London, England), 390, 2673 – 2734. https://doi.org/10.1016/S0140-6736(17)31363-6 First citation in articleCrossrefGoogle Scholar

  • Mahoney, F. I. & Barthel, D. W. (1965). Functional evaluation: the Barthel index. Maryland State Medical Journal, 14, 61 – 65. First citation in articleGoogle Scholar

  • Manckoundia, P., Taroux, M., Kubicki, A. & Mourey, F. (2014). Impact of ambulatory physiotherapy on motor abilities of elderly subjects with Alzheimer’s disease. Geriatrics & Gerontology International, 14, 167 – 175. https://doi.org/10.1111/ggi.12075 First citation in articleCrossrefGoogle Scholar

  • Nakayama, N., Suzuki, M. & Hamaguchi, T. (2019). Relationship between knee extension strength and gait styles in patients with dementia. Medicine, 98, e14958. https://doi.org/10.1097/MD.0000000000014958 First citation in articleCrossrefGoogle Scholar

  • Öhman, H., Savikko, N., Strandberg, T. E. & Pitkälä, K. H. (2014). Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: A systematic review. Dementia and Geriatric Cognitive Disorders, 38, 347 – 365. https://doi.org/10.1159/000365388 First citation in articleCrossrefGoogle Scholar

  • Perrochon, A., Tchalla, A. E., Bonis, J., Perucaud, F. & Mandigout, S. (2015). Effects of a multicomponent exercise program on spatiotemporal gait parameters, risk of falling and physical activity in dementia patients. Dementia and Geriatric Cognitive Disorders Extra, 5, 350 – 360. https://doi.org/10.1159/000435772 First citation in articleCrossrefGoogle Scholar

  • Pitkälä, K. H., Savikko, N., Pöysti, M. M., Strandberg, T. E. & Laakkonen, M.–L. (2013). Efficacy of physical exercise intervention on mobility and physical functioning in older people with dementia: A systematic review. Experimental Gerontology, 48, 85 – 93. https://doi.org/10.1016/j.exger.2012.08.008 First citation in articleCrossrefGoogle Scholar

  • Podsiadlo, D. & Richardson, S. (1991). The timed “Up & Go”: A test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society, 39, 142 – 148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x First citation in articleCrossrefGoogle Scholar

  • Reitan, R. M. (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271 – 276. https://doi.org/10.2466/pms.1958.8.3.271 First citation in articleCrossrefGoogle Scholar

  • Reitan, R. M. (1992). Trail Making Test: Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory. First citation in articleGoogle Scholar

  • Reuben, D. B. & Siu, A. L. (1990). An objective measure of physical function of elderly outpatients. The Physical Performance Test. Journal of the American Geriatrics Society, 38, 1105 – 1112. https://doi.org/10.1111/j.1532-5415.1990.tb01373.x First citation in articleCrossrefGoogle Scholar

  • Ries, J. D., Echternach, J. L., Nof, L. & Gagnon Blodgett, M. (2009). Test-retest reliability and minimal detectable change scores for the timed “up & go” test, the six-minute walk test, and gait speed in people with Alzheimer disease. Physical Therapy, 89, 569 – 579. https://doi.org/10.2522/ptj.20080258 First citation in articleCrossrefGoogle Scholar

  • Rockwood, K., Awalt, E., Carver, D. & MacKnight, C. (2000). Feasibility and measurement properties of the functional reach and the timed up and go tests in the Canadian study of health and aging. The Journals of Gerontology Series a: Biological Sciences and Medical Sciences, 55 M, 70 – 73. https://doi.org/10.1093/gerona/55.2.M70 First citation in articleCrossrefGoogle Scholar

  • Rolland, Y. M., Pillard, F., Klapouszczak, A., Reynish, E., Thomas, D. R., Andrieu, S. et al. (2007). Exercise program for nursing home residents with Alzheimer’s disease: A 1-year randomized, controlled trial. Journal of the American Geriatrics Society, 55, 158 – 165. https://doi.org/10.1111/j.1532-5415.2007.01035.x First citation in articleCrossrefGoogle Scholar

  • Rossiter-Fornoff, J. E., Wolf, S. L., Wolfson, L. I. & Buchner, D. M. (1995). A cross-sectional validation study of the FICSIT common data base static balance measures. Frailty and Injuries: Cooperative Studies of Intervention Techniques. The Journals of Gerontology Series a: Biological Sciences and Medical Sciences, 50 M, 291 – 297. https://doi.org/10.1093/gerona/50A.6.M291 First citation in articleCrossrefGoogle Scholar

  • Saghaei, M. & Saghaei, S. (2011). Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials. Journal of Biomedical Science and Engineering, 4, 734 – 739. https://doi.org/10.4236/jbise.2011.411090 First citation in articleCrossrefGoogle Scholar

  • Sass, A. C., Wurm, S. & Scheidt-Nave, C. (2010). Alter und Gesundheit: Eine Bestandsaufnahme aus Sicht der Gesundheitsberichterstattung. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 53, 404 – 416. https://doi.org/10.1007/s00103-010-1049-4 First citation in articleCrossrefGoogle Scholar

  • Schwenk, M., Hauer, K., Zieschang, T., Englert, S., Mohler, J. & Najafi, B. (2014). Sensor-derived physical activity parameters can predict future falls in people with dementia. Gerontology, 60, 483 – 492. https://doi.org/10.1159/000363136 First citation in articleCrossrefGoogle Scholar

  • Schwenk, M., Schmidt, M., Pfisterer, M., Oster, P. & Hauer, K. (2011). Rollator use adversely impacts on assessment of gait and mobility during geriatric rehabilitation. Journal of Rehabilitation Medicine, 43, 424 – 429. https://doi.org/10.2340/16501977-0791 First citation in articleCrossrefGoogle Scholar

  • Schwenk, M., Zieschang, T., Englert, S., Grewal, G., Najafi, B. & Hauer, K. (2014). Improvements in gait characteristics after intensive resistance and functional training in people with dementia. A randomised controlled trial. BMC Geriatrics, 14. https://doi.org/10.1186/1471-2318-14-73 First citation in articleCrossrefGoogle Scholar

  • Shulman, K. I., Shedletsky, R. & Silver, I. L. (1986). The challenge of time. Clock-drawing and cognitive function in the elderly. International Journal of Geriatric Psychiatry, 1, 135 – 140. https://doi.org/10.1002/gps.930010209 First citation in articleCrossrefGoogle Scholar

  • Suttanon, P., Hill, K. D., Said, C. M. & Dodd, K. J. (2010). Can balance exercise programmes improve balance and related physical performance measures in people with dementia? A systematic review. European Review of Aging and Physical Activity, 7, 13 – 25. https://doi.org/10.1007/s11556-010-0055-8 First citation in articleCrossrefGoogle Scholar

  • Suttanon, P., Hill, K. D., Said, C. M., LoGiudice, D., Lautenschlager, N. T. & Dodd, K. J. (2012). Balance and mobility dysfunction and falls risk in older people with mild to moderate Alzheimer disease. American Journal of Physical Medicine & Rehabilitation, 91, 12 – 23. https://doi.org/10.1097/PHM.0b013e31823caeea First citation in articleCrossrefGoogle Scholar

  • Tinetti, M. E. (1986). Performance-Oriented Assessment of Mobility problems in elderly patients. Journal of the American Geriatrics Society, 34, 119 – 126. https://doi.org/10.1111/j.1532-5415.1986.tb05480.x First citation in articleCrossrefGoogle Scholar

  • Trautwein, S., Barisch-Fritz, B., Scharpf, A., Bossers, W. J. R., Meinzer, M., Steib, S. et al. (2019). Recommendations for assessing motor performance in individuals with dementia. Suggestions of an expert panel – A qualitative approach. European Review of Aging and Physical Activity, 16. https://doi.org/10.1186/s11556-019-0212-7 First citation in articleCrossrefGoogle Scholar

  • Trautwein, S., Barisch-Fritz, B., Scharpf, A., Ringhof, S., Stein, T., Krell-Roesch, J. et al. (2020). Effects of a 16-week multimodal exercise program on gait performance in individuals with dementia: A multicenter randomized controlled trial. BMC Geriatrics, 20, 245. https://doi.org/10.1186/s12877-020-01635-3 First citation in articleGoogle Scholar

  • Trautwein, S., Maurus, P., Barisch-Fritz, B., Hadzic, A. & Woll, A. (2019). Recommended motor assessments based on psychometric properties in individuals with dementia. A systematic review. European Review of Aging and Physical Activity, 16. https://doi.org/10.1186/s11556-019-0228-z First citation in articleCrossrefGoogle Scholar

  • Trautwein, S., Scharpf, A., Barisch-Fritz, B., Niermann, C. & Woll, A. (2017). Effectiveness of a 16-week multimodal exercise program on individuals with dementia. Study protocol for a multicenter randomized controlled trial. JMIR Research Protocols, 6, e35. https://doi.org/10.2196/resprot.6792 First citation in articleCrossrefGoogle Scholar

  • Van Iersel, M. B., Benraad, C. E. M. & Olde Rikkert, M. G. M. (2007). Validity and reliability of quantitative gait analysis in geriatric patients with and without dementia. Journal of the American Geriatrics Society, 55, 632 – 634. https://doi.org/10.1111/j.1532-5415.2007.01130.x First citation in articleCrossrefGoogle Scholar

  • Versijpt, J. (2014). Effectiveness and cost-effectiveness of the pharmacological treatment of Alzheimer’s disease and vascular dementia. Journal of Alzheimer’s Disease: JAD, 42 S, 19 – 25. https://doi.org/10.3233/JAD-132639 First citation in articleCrossrefGoogle Scholar

  • Voelcker-Rehage, C., Godde, B. & Staudinger, U. M. (2006). Bewegung, körperliche und geistige Mobilität im Alter. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 49, 558 – 566. https://doi.org/10.1007/s00103-006-1269-9 First citation in articleCrossrefGoogle Scholar

  • Walker, L., McAleese, K. E., Erskine, D. & Attems, J. (2019). Neurodegenerative diseases and ageing. In J. R. HarrisV. I. Korolchuk (Eds.), Biochemistry and cell biology of ageing. Part II clinical science (pp. 75 – 106). Singapore: Springer. https://doi.org/10.1007/978-981-13-3681-2_4 First citation in articleCrossrefGoogle Scholar

  • Weintraub, S., Wicklund, A. H. & Salmon, D. P. (2012). The neuropsychological profile of Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 2. https://doi.org/10.1101/cshperspect.a006171 First citation in articleCrossrefGoogle Scholar

  • Werner, C., Wiloth, S., Lemke, N. C., Kronbach, F. & Hauer, K. (2018). Development and validation of a novel motor-cognitive assessment strategy of compensatory sit-to-stand maneuvers in people with dementia. Journal of Geriatric Physical Therapy, 41, 143 – 154. https://doi.org/10.1519/JPT.0000000000000116 First citation in articleCrossrefGoogle Scholar

  • WHO (Hrsg.). (2022). Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. 10. Revision, German Modification, Version 2022. Verfügbar unter: https://www.dimdi.de/static/de/klassifikationen/icd/icd-10-gm/kode-suche/htmlgm2022/block-f00-f09.htm First citation in articleGoogle Scholar

  • Wilde, N. J., Strauss, E. & Tulsky, D. S. (2004). Memory span on the Wechsler Scales. Journal of Clinical and Experimental Neuropsychology, 26, 539 – 549. https://doi.org/10.1080/13803390490496605 First citation in articleCrossrefGoogle Scholar

  • Wiloth, S., Lemke, N. C., Werner, C. & Hauer, K. (2016). Validation of a computerized, game-based assessment strategy to measure training effects on motor-cognitive functions in people with dementia. JMIR Serious Games, 4, e12. https://doi.org/10.2196/games.5696 First citation in articleCrossrefGoogle Scholar