The biosynthesis of steroid hormones is a fascinating process . In this reaction cascade, cholesterol, a normal constituent of the lipid membrane bylayers, is coverted through a number of hydroylation, oxidation and reduction steps into a variety of ...

Bone is a dynamic tissue that undergoes renewal and repair throughout life through the process of bone remodelling. Skeletal homeostasis is achieved through coupled and balanced bone resorption and bone formation. Several local and systemic factors ...

Diagnosis and therapy of male hypogonadism is still a challenge because of the unspecific clinical signs and symptoms. The clinical presentation of a androgen deficiency is age-related. In the adult men, one can often observe fatigue, decrease in physical ...

The definition of late onset hypogonadism in the aging male is controversially debated, and according to the latest literature consists of at least three especially sexual symptoms such as loss of morning erection, low sexual desire and erectile ...

The publication of the first report of the Women's Health Inititiave in 2002, which evaluated the efficacy and the risks of substitution of postmenopausal women with estrogens and gestagens, has exerted a profound negative impact on the utilization of ...

Background: Over the last years, various revelations demonstrated that the doping problem is far from being solved. These included the American cyclist Lance Armstrong's disclosure and subsequent conviction for doping abuse over a period of many years. ...