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An ERP Investigation of Semantic Priming, Repetition Priming, and Negative Priming in Schizophrenic Patients

Published Online:October 03, 2006https://doi.org/10.1027/0269-8803.20.3.195

Abstract

The processing of attended and nonattended stimuli in schizophrenic patients was examined with event-related potentials (ERPs) in a lexical decision task. In positive semantic and repetition priming the N400 amplitude did not differ between a group of 17 medicated schizophrenic patients and a group of 20 matched healthy controls. However, negative priming affected the N400 only in controls. Reaction time effects were dissociated from these ERP effects, with patients showing stronger positive priming than controls but identical negative priming. The semantic processes related to the N400 appear to be intact in schizophrenic patients, but patients seem to incorporate less context information (about the nonattended prime) in their episodic memory traces. A stronger increase of the posterior late positive complex in parallel to the stronger positive priming in schizophrenic patients may reflect relatively stronger automatic memory retrieval processes in patients.

References

  • Adams, J. , Faux, S.F. , Nestor, P.G. , Shenton, M. , Marcy, B. , Smith, S. , McCarley, R.W. (1993). ERP abnormalities during semantic processing in schizophrenia. Schizophrenia Research, 10, 247– 257 First citation in articleCrossref, Google Scholar

  • Aleman, A. , Hijman, R. , de Haan, E.H. , Kahn, R.S. (1999). Memory impairment in schizophrenia: A meta-analysis. American Journal of Psychiatry, 156, 1358– 1366 First citation in articleGoogle Scholar

  • Aloia, M.S. , Gourovitch, M.L. , Missar, D. , Pickar, D. , Weinberger, D.R. , Goldberg, T.E. (1998). Cognitive substrates of thought disorder, II: Specifying a candidate cognitive mechanism. American Journal of Psychiatry, 155, 1677– 1684 First citation in articleCrossref, Google Scholar

  • Andreasen, N.C. (1984). Scale for the Assessment of Negative Symptoms (SANS) . Iowa City, IA: Department of Psychiatry, University of Iowa College of Medicine First citation in articleGoogle Scholar

  • Andreasen, N.C. , Grove, W.M. (1986). Thought, language, and communication in schizophrenia: Diagnosis and prognosis. Schizophrenia Bulletin, 12, 348– 59 First citation in articleCrossref, Google Scholar

  • Andrews, S. , Shelley, A.M. , Ward, P.B. , Fox, A. , Catts, S.V. , McConaghy, N. (1993). Event-related potential indices of semantic processing in schizophrenia. Biological Psychiatry, 34, 443– 458 First citation in articleCrossref, Google Scholar

  • Barch, D.M. , Cohen, J.D. , Servan-Schreiber, D. , Steingard, S. , Steinhauer, S.S. , van Kammen, D.P. (1996). Semantic priming in schizophrenia: An examination of spreading activation using word pronunciation and multiple SOAs. Journal of Abnormal Psychology, 105, 592– 601 First citation in articleCrossref, Google Scholar

  • Baving, L. , Wagner, M. , Cohen, R. , Rockstroh, B. (2001). Increased repetition and semantic priming in schizophrenic patients. Journal of Abnormal Psychology, 110, 67– 75 First citation in articleCrossref, Google Scholar

  • Beech, A. , Powell, T. , McWilliam, J. , Claridge, G. (1989). Evidence of reduced “cognitive inhibition” in schizophrenia. British Journal of Clinical Psychology, 28, 109– 116 First citation in articleCrossref, Google Scholar

  • Bentin, S. , McCarthy, G. , Wood, C.C. (1985). Event-related potentials, lexical decision and semantic priming. Electroencephalography and Clinical Neurophysiology, 60, 343– 355 First citation in articleCrossref, Google Scholar

  • Bentin, S. , Kutas, M. , Hillyard, S.A. (1995). Semantic processing and memory for attended and unattended words in dichotic listening: Behavioral and electrophysiological evidence. Journal of Experimental Psychology: Human Perception and Performance, 21, 54– 67 First citation in articleCrossref, Google Scholar

  • Berg, P. , Scherg, M. (1994). A multiple source approach to the correction of eye artifacts. Electroencephalography and Clinical Neurophysiology, 90, 229– 241 First citation in articleCrossref, Google Scholar

  • Boddy, J. (1986). Event-related potentials in chronometric analysis of primed word recognition with different stimulus onset asynchronies. Psychophysiology, 23, 232– 245 First citation in articleCrossref, Google Scholar

  • Braff, D.L. , Saccuzzo, D.P. (1985). The time course of information-processing deficits in schizophrenia. American Journal of Psychiatry, 142, 170– 174 First citation in articleCrossref, Google Scholar

  • Brown, C. , Hagoort, P. (1993). The processing nature of the N400: Evidence from masked priming. Journal of Cognitive Neuroscience, 5, 34– 44 First citation in articleCrossref, Google Scholar

  • Callaway, E. , Naghdi, S. (1982). An information processing theory of schizophrenia. Archives of General Psychiatry, 39, 339– 347 First citation in articleCrossref, Google Scholar

  • Chapman, L.J. , Chapman, J.P. (1973). Disordered thought in schizophrenia . Englewood Cliffs, NJ: Prentice Hall First citation in articleGoogle Scholar

  • Chapman, L.J. , Chapman, J.P. , Curran, T.E. , Miller, M.B. (1994). Do children and the elderly show heightened semantic priming? How to answer the question. Developmental Review, 14, 159– 185 First citation in articleCrossref, Google Scholar

  • Chwilla, D. , Brown, C.M. , Hagoort, P. (1995). The N400 as a function of the level of processing. Psychophysiology, 32, 274– 285 First citation in articleCrossref, Google Scholar

  • Clare, L. , McKenna, P.J. , Mortimer, A.M. , Baddeley, A.D. (1993). Memory in schizophrenia: What is impaired and what is preserved?. Neuropsychologia, 31, 1225– 1241 First citation in articleCrossref, Google Scholar

  • Cohen, J.D. , Braver, T.S. , O'Reilly, R.C. (1996). A computational approach to prefrontal cortex, cognitive control and schizophrenia: Recent developments and current challenges. Philosophical Transactions of the Royal Society London Biological Sciences, 351, 1515– 1527 First citation in articleCrossref, Google Scholar

  • Cohen, R. (1991). Event-related potentials and cognitive dysfunctions in schizophrenia. In H. Häfner & W.F. Gattaz (Eds.), Search for the causes of schizophrenia (Vol. II, pp. 342-360). New York: Springer First citation in articleGoogle Scholar

  • Condray, R. , Steinhauer, S.R. , Cohen, J.D. , van Kammen, D.P. , Kasparek, A. (1999). Modulation of language processing in schizophrenia: Effects of context and haloperidol on the event-related potential. Biological Psychiatry, 45, 1136– 1355 First citation in articleCrossref, Google Scholar

  • Condray, R. , Steinhauer, S.R. , van Kammen, D.P. , Kasparek, A. (1996). Working memory capacity predicts language comprehension in schizophrenic patients. Schizophrenia Research, 20, 1– 13 First citation in articleCrossref, Google Scholar

  • Conklin, H.M. , Curtis, C.E. , Katsanis, J. , Iacono, W.G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the digit span task. American Journal of Psychiatry, 157, 275– 277 First citation in articleCrossref, Google Scholar

  • Doyle, M.C. , Rugg, M.D. (1998). Word repetition within- and across-visual fields: An event-related potential study. Neuropsychologia, 36, 1403– 1415 First citation in articleCrossref, Google Scholar

  • Elbert, T. , Lutzenberger, W. , Rockstroh, B. , Birbaumer, N. (1985). Removal of ocular artifacts from the EEG - a biophysical approach. Electroencephalography and Clinical Neurophysiology, 60, 455– 463 First citation in articleCrossref, Google Scholar

  • Fox, E. (1995). Negative priming from ignored distractors in visual selection: A review. Psychonomic Bulletin and Review, 2, 145– 173 First citation in articleCrossref, Google Scholar

  • Fraser, W.I. , King, K.M. , Thomas, P. , Kendell, R.E. (1986). The diagnosis of schizophrenia by language analysis. British Journal of Psychiatry, 148, 275– 278 First citation in articleCrossref, Google Scholar

  • Goldman-Rakic, P.S. (1994). Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences, 6, 348– 357 First citation in articleCrossref, Google Scholar

  • Green, M. , Walker, E. (1985). Neuropsychological performance and positive and negative symptoms in schizophrenia. Journal of Abnormal Psychology, 94, 460– 469 First citation in articleCrossref, Google Scholar

  • Grillon, C. , Ameli, R. , Glazer, W.M. (1991). N400 and semantic categorization in schizophrenia. Biological Psychiatry, 29, 467– 480 First citation in articleCrossref, Google Scholar

  • Hager, W. , Hasselhorn, M. Eds. (1994). Handbuch deutschsprachiger Wortnormenplain . [Handbook of German word norms] Göttingen: Hogrefe First citation in articleGoogle Scholar

  • Heil, M. , Rolke, B. , Pecchinenda, A. (2004). Automatic semantic activation is no myth: Semantic context effects on the N400 in the letter-search task in the absence of response time effects. Psychological Science, 15, 852– 857 First citation in articleCrossref, Google Scholar

  • Hönig, K. , Hochrein, A. , Muller, D.J. , Wagner, M. (2002). Different negative priming impairments in schizophrenia and subgroups of obsessive-compulsive disorder. Psychological Medicine, 32, 459– 468 First citation in articleGoogle Scholar

  • Holcomb, P.J. (1993). Semantic priming and stimulus degradation: Implications for the role of the N400 in language processing. Psychophysiology, 30, 47– 61 First citation in articleCrossref, Google Scholar

  • Johnson, M.K. , Kuonios, J. , Nolde, S.F. (1996). Electrophysiological brain activity and memory source monitoring. Neuroreport, 7, 2929– 2932 First citation in articleCrossref, Google Scholar

  • Kathmann, N. , Bogdahn, B. , Endrass, T. (2006). Event-related brain potential variations during location and identity negative priming. Neuroscience Letters, 394, 53– 56 First citation in articleCrossref, Google Scholar

  • Kay, S.R. , Fiszbein, L.A. , Opler, L.A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261– 276 First citation in articleCrossref, Google Scholar

  • Koyama, S. , Hokama, H. , Miyatani, M. , Ogura, C. , Nageishi, Y. , Shimokochi, M. (1994). ERPs in schizophrenic patients during word recognition task and reaction time. Electroencephalography and Clinical Neurophysiology, 92, 546– 554 First citation in articleCrossref, Google Scholar

  • Koyama, S. , Nageishi, Y. , Shimokochi, M. , Hokama, H. , Miyazato, Y. , Miyatani, M. , Ogura, C. (1991). The N400 component of event-related potentials in schizophrenic patients: A preliminary study. Electroencephalography and Clinical Neurophysiology, 78, 124– 132 First citation in articleCrossref, Google Scholar

  • Kutas, M. , Hillyard, S.A. (1980). Reading senseless sentences: Brain potentials reflect semantic incongruity. Science, 207, 203– 205 First citation in articleCrossref, Google Scholar

  • Kutas, M. , Hillyard, S.A. (1983). Event-related brain potentials to grammatical errors and semantic anomalies. Memory and Cognition, 11, 539– 550 First citation in articleCrossref, Google Scholar

  • Kutas, M. , Hillyard, S.A. (1984). Brain potentials during reading reflect word expectancy and semantic association. Nature, 307, 161– 163 First citation in articleCrossref, Google Scholar

  • Logan, G.D. (1990). Repetition priming and automaticity: Common underlying mechanisms?. Cognitive Psychology, 22, 1– 35 First citation in articleCrossref, Google Scholar

  • Lukoff, D. , Nuechterlein, K.H. , Ventura, J. (1986). Manual for expanded Brief Psychiatric Rating Scale (BPRS). Schizophrenia Bulletin, 12, 594– 601 First citation in articleGoogle Scholar

  • Maher, B.A. , Manschreck, T.C. , Redmond, D. , Beaudette, S. (1996). Length of illness and the gradient from positive to negative semantic priming in schizophrenic patients. Schizophrenia Research, 22, 127– 132 First citation in articleCrossref, Google Scholar

  • Matsuoka, H. , Matsumoto, K. , Yamazaki, H. , Sakai, H. , Miwa, S. , Yoshida, S. (1999). Lack of repetition priming effect on visual event-related potentials in schizophrenia. Biological Psychiatry, 46, 137– 140 First citation in articleCrossref, Google Scholar

  • Mayr, S. , Niedeggen, M. , Buchner, A. , Pietrowsky, R. (2003). ERP correlates of auditory negative priming. Cognition, 90, B11– B21 First citation in articleGoogle Scholar

  • Mitchell, P.F. , Andrews, S. , Fox, A.M. , Catts, S.V. , Ward, P.B. , McConaghy, N. (1991). Active and passive attention in schizophrenia: An ERP study of information processing in a linguistic task. Biological Psychology, 32, 101– 134 First citation in articleCrossref, Google Scholar

  • Moritz, S. , Ruff, C. , Wilke, U. , Andresen, B. , Krausz, M. , Naber, D. (2001). Reduced negative priming in schizophrenia: Effects of masking and prime presentation time. Schizophrenia Research, 48, 291– 299 First citation in articleCrossref, Google Scholar

  • Neely, J.H. , Keefe, D.E. (1989). Semantic context effects on visual word processing: A hybrid prospective/retrospective processing theory. In G.H. Bower (Ed.), The psychology of learning and motivation: Advances in research and theory (Vol. 23, pp. 207-248). New York: Academic Press First citation in articleGoogle Scholar

  • Nestor, P.G. , Kimble, M.O. , O'Donnell, B.F. , Smith, L. , Niznikiewicz, M. , Shenton, M.E. , McCarley, R.W. (1997). Aberrant semantic activation in schizophrenia: A neurophysiological study. American Journal of Psychiatry, 154, 640– 646 First citation in articleCrossref, Google Scholar

  • O'Donnell, B.F. , McCarley, R.W. , Potts, G.F. , Salisbury, D.F. , Nestor, P.G. , Hirayasu, Y. (1999). Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology, 36, 388– 398 First citation in articleCrossref, Google Scholar

  • Oldfield, R.C. (1971). The assessment and analysis of handedness.The Edinburgh Inventory. Neuropsychologia, 9, 97– 113 First citation in articleCrossref, Google Scholar

  • Overall, J.E. , Gorham, D.R. (1962). The brief psychiatric rating scale. Psychological Reports, 10, 799– 812 First citation in articleCrossref, Google Scholar

  • Polich, J. (1985). Semantic categorization and event-related potentials. Brain and Language, 26, 304– 321 First citation in articleCrossref, Google Scholar

  • Rockstroh, B. , Elbert, T. , Canavan, A. , Lutzenberger, W. , Birbaumer, N. (1989). Slow cortical potentials and behaviour . Munich: Urban and Schwarzenberg First citation in articleGoogle Scholar

  • Rößner, P. , Rockstroh, B. , Cohen, R. , Wagner, M. , Elbert, T. (1999). Event-related potential correlates of proactive interference in schizophrenic patients and controls. Psychophysiology, 36, 199– 208 First citation in articleCrossref, Google Scholar

  • Rothermund, K. , Wentura, D. , De Houwer, J. (2005). Retrieval of incidental stimulus-response associations as a source of negative priming. Journal of Experimental Psychology: Learning, Memory and Cognition, 31, 482– 495 First citation in articleCrossref, Google Scholar

  • Rugg, M.D. (1985). The effects of semantic priming and word repetition on event-related potentials. Psychophysiology, 22, 642– 647 First citation in articleCrossref, Google Scholar

  • Rugg, M.D. , Brovedani, P. , Doyle, M.C. (1992). Modulation of event-related potentials (ERPs) by word repetition in a task with inconsistent mapping between repetition and response. Electroencephalography and Clinical Neurophysiology, 84, 521– 531 First citation in articleCrossref, Google Scholar

  • Rugg, M.D. , Mark, R.E. , Walla, P. , Schloerscheidt, A.M. , Birch, C.S. , Allan, K. (1998). Dissociation of the neural correlates of implicit and explicit memory. Nature, 392, 595– 598 First citation in articleCrossref, Google Scholar

  • Ruoff, A. (1990). Häufigkeitswörterbuch gesprochener Sprache . [Dictionary of German word frequencies] (2nd ed.). Tübingen: Niemeyer First citation in articleGoogle Scholar

  • Schmidt, K.H. , Metzler, P. (1992). Wortschatztest (WST) . [Vocabulary test]. Weinheim: Beltz First citation in articleGoogle Scholar

  • Spitzer, M. , Weisbrod, M. , Winkler, S. , Maier, S. (1997). Ereigniskorrelierte Potentiale bei semantischen Sprachverarbeitungsprozessen schizophrener Patienten. [Event-related potentials in semantic information processing in schizophrenic patients] Nervenarzt, 68, 212– 225 First citation in articleCrossref, Google Scholar

  • Tipper, S.P. (1985). The negative priming effect: Inhibitory priming by ignored objects. Quarterly Journal of Experimental Psychology, 37, 571– 590 First citation in articleCrossref, Google Scholar

  • VanPetten, C. , Kutas, M. , Kluender, R. , Mitchiner, M. , McIsaac, H. (1991). Fractionating the word repetition effect with event-related potentials. Journal of Cognitive Neuroscience, 3, 131– 150 First citation in articleCrossref, Google Scholar

  • Williams, L. (1996). Cognitive inhibition and schizophrenic symptom subgroups. Schizophrenia Bulletin, 22, 139– 151 First citation in articleCrossref, Google Scholar

  • Wing, J.K. , Cooper, J.E. , Sartorius, N. (1974). Measurement and classification of psychiatric symptoms . London: Cambridge University Press First citation in articleGoogle Scholar

  • Zabal, A. , Buchner, A. (in press). Normal auditory negative priming in schizophrenic patients. Quarterly Journal of Experimental Psychology, First citation in articleGoogle Scholar