Abstract
Zusammenfassung. Patienten mit Depressionen klagen häufig über Symptome und Störungen nicht nur auf der emotionalen, sondern auch auf der kognitiven Ebene. In dieser Übersichtsarbeit werden schwerpunktmäßig neuropsychologische Befunde zu kognitiven Funktionen bei unipolaren Depressionen zusammengefasst. Die kognitive Theorie der Depression postulierte eine Beeinflussung kognitiver Vorgänge durch emotionale Verzerrungen, die eine wichtige Rolle bei Vulnerabilität, Entstehung, Aufrechterhaltung und Rezidiven depressiver Episoden spielen. Befunde zu dieser Interaktion von kognitiven und emotionalen Prozessen werden dargestellt, außerdem wird auf die Bedeutung dieser Aspekte für die Emotionsregulation und für die Therapie der Depression eingegangen.
Abstract. Patients suffering from major depressive disorder often complain not only of emotional, but also of cognitive symptoms and problems. Here, we mainly review neuropsychological findings on cognitive functions and disturbances in major depression. The cognitive theory of depression hypothesized biased information processing due to emotional effects which influences vulnerability, development, maintenance and recurrence of depressive episodes. Therefore, we further review findings on the interaction of cognitive and emotional processes in depression and also address the influence of these aspects for emotion regulation and therapy of depression.
Literatur
(1990). Neuropsychological deficits and CT scan changes in elderly depressives. Psychological Medicine, 20, 507–520.
(2007). Anticipation of aversive stimuli activates extended amygdala in unipolar depression. Journal of Psychiatric Research, 41, 511–522.
(2000). Word Fluency: Regensburger Wortflüssigkeitstest (RWT). Göttingen: Hogrefe.
(2006). Wechsler Intelligenztest für Erwachsene (WIE-III). Frankfurt: Pearson.
(2002). SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients. Nuclear Medicine Communication, 23, 907–916.
(1999). Cognitive function in depression: a distinct pattern of frontal impairment in melancholia? Psychological Medicine, 29, 73–85.
(2003). Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. Biological Psychiatry, 53, 376–384.
(2004). Executive deficits in elderly patients with major unipolar depression. Journal of Geriatric Psychiatry and Neurology, 17, 195–201.
(1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46, 243–250.
(1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychological Medicine, 26, 591–603.
(1999). Neuropsychological correlates of major depression: a short-term follow-up. Cognitive Neuropsychiatry, 4, 333–341.
(2006). Neuropsychologie der Depression. Göttingen: Hogrefe.
(2000). Neuropsychologische Defizite bei depressiven Störungen. Fortschritte der Neurologie – Psychiatrie, 68, 1–11.
(1976). Cognitive Therapy and the Emotional Disorders. New York: International University Press.
(1992). The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. Psychological Medicine, 22, 607–615.
(1993). Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Regional cerebral blood flow during cognitive activation. British Journal of Psychiatry, 162, 183–192.
(2007). A longitudinal analysis of neurocognitive function in unipolar depression. Journal of Clinical and Experimental Neuropsychology, 29, 879–891.
(2009). Course and outcome of depression. In I.H. Gotlib & C.L. Hammen (Eds.), Handbook of Depression (pp. 23–43). New York: Guilford.
(1981). Mood and memory. American Psychologist, 36, 129–148.
(1997). Attentional biases for negative information in induced and naturally occurring dysphoria. Behaviour Research and Therapy, 35, 911–927.
(1999). Autobiographical memory processes and the course of depression. Journal of Abnormal Psychology, 108, 511–517.
(2010). D2-R. Göttingen: Hogrefe.
(1993). Autobiographical memory in depression: state or trait marker? British Journal of Psychiatry, 162, 118–121.
(1995). Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychological Bulletin, 117, 285–305.
(2000). Changes in cognitive functioning following treatment of late-life depression. American Journal of Psychiatry, 157, 1949–1954.
(2006). Acceptability and suppression of negative emotion in anxiety and mood disorders. Emotion, 6, 587–595.
(2007). Biases in visual orienting to negative and positive scenes in dysphoria: An eye movement study. Journal of Abnormal Psychology, 116, 491–497.
(1993). Working memory in clinical depression: an experimental study. Psychological Medicine, 23, 87–91.
(2005). Effects of sertraline on depressive symptoms and attentional and executive functions in major depression. Depression and Anxiety, 21, 78–89.
(2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience, 3, 201–215.
(2005). Distinctions between bipolar and unipolar depression. Clinical Psychology Review, 25, 307–339.
(2001). Autobiographical Memory style in seasonal affective disorder and its relationship to future symptom remission. Journal of Abnormal Psychology, 110, 335–340.
(2000). Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience, 3, 1049–1056.
(2009). Interpretation of ambiguous information in girls at risk for depression. Journal of Abnormal Child Psychology, 37, 79–91.
(1998). Executive deficits in major depression. Acta Psychiatrica Scandinavica, 97, 182–188.
(1993). Effect of depression on psychomotor skills, eye movements and recognition-memory. Journal of Affective Disorders, 29, 33–40.
(2009). Longitudinal assessment of neuropsychological function in major depression. Australian and New Zealand Journal of Psychiatry, 43, 1105–1117.
(2008). The role of rumination and reduced concreteness in the maintenance of posttraumatic stress disorder and depression following trauma. Cognitive Therapy and Research, 32, 488–506.
(2003). A naturalistic visual scanning approach to assess selective attention in major depressive disorder. Psychiatry Research, 118, 117–128.
(1996). Neuropsychological impairments in unipolar depression: The influence of perceived failure on subsequent performance. Psychological Medicine, 26, 975–989.
(1997). Prefrontal dysfunction in depressed patients performing a complex planning task: A study using positron emission tomography. Psychological Medicine, 27, 931–942.
(2005). Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder. American Journal of Psychiatry, 162, 2171–2173.
(2000). Executive frontal functions. Experimental Brain Research, 133, 66–70.
(2007). Neurocognitive function following remission in major depressive disorder: potential objective marker of response? Australian and New Zealand Journal of Psychiatry, 41, 54–61.
(1995). Construct validity in the Trail Making Test: what makes Part B harder? Journal of Clinical and Experimental Neuropsychology, 17, 529–535.
(2008). Osnabrücker Turm von Hanoi (TvH). Göttingen: Hogrefe.
(1995). Architecture of the prefrontal cortex and the central executive. Annals of the New York Academy of Sciences, 769, 71–83.
(2010). Cognition and depression: current status and future directions. Annual Review of Clinical Psychology, 6, 285–312.
(1988). Biases in Visual Attention in Depressed and Nondepressed Individuals. Cognition & Emotion, 2, 185–200.
(2001). Verbaler Lern- und Merkfähigkeitstest (VLMT). Göttingen: Beltz-Test.
(1993). Tempo-Lern-Test (TLT). In K. D. Hänsgen & T. Merten (Hrsg.), Programmsystem zur Psychodiagnostik – LEILA – Leistungsdiagnostisches Labor. Handbuch. (S. C52–C60). Göttingen: Hogrefe.
(1998). Vigilance performance in Parkinson’s disease and depression. Journal of Clinical and Experimental Neuropsychology, 20, 111–117.
(2000). Wechsler-Memory-Scale Revised (WMS-R). Bern: Hans Huber.
(1979). Automatic and effortful processing in memory. Journal of Experimental Psychology: General, 108, 356–388.
(2005). A meta-analytic review of verbal fluency deficits in depression. Journal of Clinical and Experimental Neuropsychology, 27, 78–101.
(2010a). Self-related awareness and emotion regulation. Neuroimage, 50, 734–741.
(2010b). Neural correlates of ‹pessimistic› attitude in depression. Psychological Medicine, 40, 789–800.
(2007). Neural correlates of a ‹pessimistic› attitude when anticipating events of unknown emotional valence. NeuroImage, 2007, 34(2), 848–858.
(2010). Executive deficits, repressive coping behaviour and the overestimation memory performance. Zeitschrift für Neuropsychologie, 21, 7–16.
(1984). Toward an information-processing analysis of depression. Cognitive Therapy and Research, 8, 443–477.
(2008). Wieviel ‹Neuro› ist in der neuropsychologischen Diagnostik von Aufmerksamkeit? Zeitschrift für Neuropsychologie, 19, 91–95.
(2010). Emotion regulation in depression: Relation to Cognitive Inhibition. Cognition & Emotion, 24, 281–298.
(2009). Verbal working memory and functional outcome in patients with unipolar major depressive disorder. World Journal of Biological Psychiatry, 10, 591–594.
(2001). Neuropsychological dysfunction in depressed suicide attempters. American Journal of Psychiatry, 158, 735–741.
(2008). Neural Responses to Monetary Incentives in Major Depression. Biological Psychiatry, 63, 686–692.
(2008). Anticipatory affect: neural correlates and consequences for choice. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3771–3786.
(2008). Continuous Performance Task. Göttingen: Hogrefe.
(2002). Interpretation revealed in the blink of an eye: depressive bias in the resolution of ambiguity. Journal of Abnormal Psychology, 111, 321–328.
(1995). Neuropsychological Assessment. New York: Oxford University Press.
(2002). Executive dysfunction in geriatric depression. American Journal of Psychiatry, 159, 1119–1126.
(1952). Nondementing psychoses in older persons. Journal of the American Medical Association, 150, 1567–1572.
(2010). Cognitive impairment in major depression. European Journal of Pharmacology, 626, 83–86.
(2000). Gehirn und Verhalten. Ein Grundkurs der physiologischen Psychologie. Heidelberg: Spektrum Akademischer Verlag.
(1994). Zur Repräsentation von Gedächtnis im Gehirn. In M. Haupts (Hrsg.), Neurologie und Gedächtnis. Bern: Huber.
(1996). Evidence of attention to threatening stimuli in depression. Behaviour Research and Therapy, 34, 695–705.
(2005). Cognitive vulnerability to emotional disorders. Annual Review of Clinical Psychology, 1, 167–195.
(1992). Mood-congruent recall of affectively toned stimuli: a meta-analytic review. Clinical Psychology Review, 12, 227–255.
(1994). Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine, 35, 929–934.
(2010). Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis. Neuropsychology, 24, 9–34.
(1990). Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Annals of Neurology, 28, 597–613.
(1993). Subliminal processing of emotional information in anxiety and depression. Journal of Abnormal Psychology, 102, 304–311.
(1996). FAIR: Frankfurter Aufmerksamkeit-Inventar. Bern: Hans Huber.
(2010). Leitlinie zur Diagnostik und Therapie von exekutiven Dysfunktionen. Zeitschrift für Neuropsychologie, 21, 167–176.
(2003). Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine. Journal of Psychiatric Research, 37, 99–108.
(2004). Prefrontal cortex activity differentiates processes affecting memory in depression. Biological Psychology, 67, 125–143.
(2005). The relation of self-report of mood and anxiety to CVLT-C, CVLT, and CVLT-2 in a psychiatric sample. Archives of Clinical Neuropsychology, 20, 547–553.
(2005). The cognitive control of emotion. Trends in Cognitive Sciences, 9, 242–249.
(2003). Attenuated left prefrontal activation during a verbal fluency task in patients with depression. Neuropsychobiology, 47, 21–26.
(1994). Norms for depressed patients for the California Verbal Learning Test: associations with depression severity and self-report of cognitive difficulties. Archives of Clinical Neuropsychology, 9, 81–88.
(2002). The neural network basis for abnormalities of attention and executive function in major depressive disorder: implications for application of the medical disease model to psychiatric disorders. Harvard Review of Psychiatry, 10, 86–99.
(2005). Attention and executive functions in remitted major depression patients. Journal of Affective Disorders, 89, 125–135.
(2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience, 9, 148–158.
(2003). Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry, 54, 515–528.
(2003). Residual cognitive impairment in late-life depression after a 12-month period follow-up. International Journal of Geriatric Psychiatry, 18, 571–576.
(2009). Cognitive deficits in the euthymic phase of unipolar depression. Psychiatry Research, 169, 235–239.
(1997). Neuropsychological function in young patients with unipolar major depression. Psychological Medicine, 27, 1277–1285.
(2002). Cognitive deficits in major depression. Scandinavian Journal of Psychology, 43, 239–251.
(1993). Neuropsychologische Diagnostik der depressiven Pseudodemenz. In H.-J. Möller & A. Rohde (Hrsg.), Psychische Krankheit im Alter (S. 272–278). Berlin: Springer.
(2007). Persistent cognitive impairment in depression: The role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biological Psychiatry, 62, 400–406.
(1989). Motivational effects on neuropsychological functioning: comparison of depressed versus nondepressed individuals. Journal of Consulting and Clinical Psychology, 57, 396–402.
(2005). A comparison of attentional biases and memory biases in women with social phobia and major depression. Journal of Abnormal Psychology, 114, 62–74.
(2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association, 301, 2462–2471.
(1993). Automatic and effortful memory processes in depressed persons. Journal of Gerontology, 48, P 87–95.
(1995). Regional cerebral blood flow in mood disorders: IV. Comparison of mania and depression. Psychiatry Research, 61, 1–10.
(2002). Negative processing biases predict subsequent depressive symptoms. Cognition & Emotion, 16, 423–440.
(1987). The Ruff Figural Fluency Test. Developmental Neuropsychology, 3, 37–51.
(1990). Regional cerebral blood flow in mood disorders. I. Comparison of major depressives and normal controls at rest. Archives of General Psychiatry, 47, 60–70.
(2000). Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness. American Journal of Psychiatry, 157, 1095–1100.
(2008). Aufmerksamkeitsdiagnostik. Ableitung eines Strukturmodells und systematische Einordnung von Tests. Zeitschrift für Neuropsychologie, 19, 59–82.
(1982). Specific impairments of planning. Philosophical Transactions of the Royal Society B: Biological Sciences, 298, 199–209.
(2006). Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biological Psychiatry, 60, 58–65.
(2006). Clinical and empirical applications of the Rey-Osterrieth Complex Figure Test. Nature Protocols, 1, 892–899.
(2007). Increased Amygdala and Decreased Dorsolateral Prefrontal BOLD Responses in Unipolar Depression: Related and Independent Features. Biological Psychiatry, 61, 198–209.
(2006). Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder. Bipolar Disorders, 8, 40–46.
(1998). A compendium of neuropsychological tests. Administration, norms and commentary. New York: Oxford University Press.
(2000). Aufmerksamkeitsstörungen. In W. Sturm, M. Herrmann & C.-W. Wallesch (Hrsg.), Lehrbuch der klinischen Neuropsychologie (S. 345–365). Lisse, NL: Swets & Zeitlinger.
(1984). Neuropsychological studies of the frontal lobes. Psychological Bulletin, 95, 3–28.
(2000). Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biological Psychiatry, 48, 674–684.
(1995). Effects of major depression on the cognitive function of younger and older subjects. Psychological Medicine, 25, 285–295.
(1988). Cognitive Vulnerability to Persistent Depression. Cognition & Emotion, 2, 247–274.
(1995). Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsychological study. Psychological Medicine, 25, 79–85.
(2005). The relationship between autobiographical memory specificity and depressed mood following a stressful life event: a prospective study. British Journal of Clinical Psychology, 44, 405–415.
(1997). A preliminary profile of neuropsychological deficits associated with major depression. Journal of Clinical and Experimental Neuropsychology, 19, 587–603.
(2004). Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry, 56, 101–112.
(2006). Verbal memory performance of mildly to moderately depressed outpatient younger adults. Journal of Affective Disorders, 92, 283–286.
(2000). Unconscious memory bias in depression: perceptual and conceptual processes. Journal of Abnormal Psychology, 109, 282–289.
(2002). Implicit memory bias in depression. Cognition & Emotion, 16, 381–402.
(2004). Evidence for continuing neuropsychological impairments in depression. Journal of Affective Disorders, 82, 253–258.
(1993). Vigilance and its disorders. Neurologic Clinics, 11, 59–78.
(2007). Autobiographical memory specificity and emotional disorder. Psychological Bulletin, 133, 122–148.
(2005). Emotion-congruent attentional biases: the perspective of hierarchical models of emotional disorders. Personality and Individual Differences, 38, 785–795.
(2008). Testbatterie zur Aufmerksamkeitsprüfung (TAP). Herzogenrath: Psytest.
(2008). RST and clinical disorders: anxiety and depression. In P. J. Corr (Ed.), The Reinforcement Sensitivity Theory of Personality (pp. 360–397). London: Cambridge University Press.