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Editorial

Circadian Rhythms, Sleep, and the Autonomic Nervous System

A Position Paper

Published Online:https://doi.org/10.1027/0269-8803/a000236
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References

  • Antelmi, I., de Paula, R. S., Shinzato, A. R., Shinzato, A. R., Peres, C. A., Mansur, A. J., & Grupi, C. J. (2004). Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. The American Journal of Cardiology, 93, 381–385. https://doi.org/10.1016/j.amjcard.2003.09.065 First citation in articleCrossrefGoogle Scholar

  • Barclay, N. L., & Gregory, A. M. (2013). Quantitative genetic research on sleep: A review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties. Sleep Medicine Reviews, 17, 29–40. https://doi.org/10.1016/j.smrv.2012.01.008 First citation in articleCrossrefGoogle Scholar

  • Berne, C., Fagius, J., Pollare, T., & Hjemdahl, P. (1992). The sympathetic response to euglycaemic hyperinsulinaemia. Diabetologia, 35, 873–879. https://doi.org/10.1007/BF00399935 First citation in articleCrossrefGoogle Scholar

  • Berntson, G. G., & Cacioppo, J. T. (2004). Heart rate variability: Stress and psychiatric conditions. In M. MalikA. J. CammEds., Dynamic electrocardiography (pp. 56–63). Elmsford, NY: Futura. First citation in articleGoogle Scholar

  • Bonnet, M. H., & Arand, D. L. (1998). Heart rate variability in insomniacs and matched normal sleepers. Psychosomatic Medicine, 60, 610–615. First citation in articleCrossrefGoogle Scholar

  • Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., … Tracey, K. J. (2000). Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature, 405, 458–462. https://doi.org/10.1038/35013070 First citation in articleCrossrefGoogle Scholar

  • Brandenberger, G., Viola, A. U., Ehrhart, J., & Charloux, A. (2003). Age-related changes in cardiac autonomic control during sleep. Journal of Sleep Research, 12, 173–180. https://doi.org/10.1046/j.1365-2869.2003.00353.x First citation in articleCrossrefGoogle Scholar

  • Burgess, H. J., Trinder, J., Kim, Y., & Luke, D. (1997). Sleep and circadian influences on cardiac autonomic nervous system activity. American Journal of Physiology, 273, H1761–H1768. https://doi.org/10.1152/ajpheart.1997.273.4.H1761 First citation in articleGoogle Scholar

  • Candelieri, A., Cortese, M. D., Dolce, G., Riganello, F., & Sannita, W. G. (2011). Visual pursuit: Within-day variability in the severe disorder of consciousness. Journal of Neurotrauma, 28, 2013–2017. https://doi.org/10.1089/neu.2011.1885 First citation in articleCrossrefGoogle Scholar

  • Costa, G., Accattoli, M. P., Garbarino, S., & Roscelli, F. (2013). Sleep disorders and work: Guidelines for health surveillance, risk management and prevention. La Medicina del Lavoro, 104, 251–266. First citation in articleGoogle Scholar

  • Crowley, S. J., Acebo, C., & Carskadon, M. A. (2007). Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Medicine, 8, 602–612. https://doi.org/10.1016/j.sleep.2006.12.002 First citation in articleCrossrefGoogle Scholar

  • De Valck, E., Cluydts, R., & Pirrera, S. (2004). Effect of cognitive arousal on sleep latency, somatic and cortical arousal following partial sleep deprivation. Journal of Sleep Research, 13, 295–304. https://doi.org/10.1111/j.1365-2869.2004.00424.x First citation in articleCrossrefGoogle Scholar

  • de Zambotti, M., Javitz, H., Franzen, P. L., Brumback, T., Clark, D. B., Colrain, I. M., & Baker, F. C. (2017). Sex- and age-dependent differences in autonomic nervous system functioning in adolescents. Journal of Adolescent Health, 62, 184–190. https://doi.org/10.1016/j.jadohealth.2017.09.010 First citation in articleCrossrefGoogle Scholar

  • Dodds, K. L., Miller, C. B., Kyle, S. D., Marshall, N. S., & Gordon, C. J. (2017). Heart rate variability in insomnia patients: A critical review of the literature. Sleep Medicine Reviews, 33, 88–100. https://doi.org/10.1016/j.smrv.2016.06.004 First citation in articleCrossrefGoogle Scholar

  • Dunlap, J. C. (2006). Physiology: Running a clock requires quality time together. Science, 311, 184–186. https://doi.org/10.1126/science.1122839 First citation in articleCrossrefGoogle Scholar

  • Eckberg, D. L. (1983). Human sinus arrhythmia as an index of vagal cardiac outflow. Journal of Applied Physiology, 54, 961–966. First citation in articleCrossrefGoogle Scholar

  • Eckberg, D. L. (2003). The human respiratory gate. The Journal of Physiology, 548, 339–352. https://doi.org/10.1113/jphysiol.2002.037192 First citation in articleGoogle Scholar

  • Esler, M. (1993). Clinical application of noradrenaline spillover methodology: Delineation of regional human sympathetic nervous responses. Basic and Clinical Pharmacology and Toxicology, 73, 243–253. https://doi.org/10.1111/j.1600-0773.1993.tb00579.x First citation in articleCrossrefGoogle Scholar

  • Fang, S.-C., Huang, C.-J., Yang, T.-T., & Tsai, P.-S. (2008). Heart rate variability and daytime functioning in insomniacs and normal sleepers: Preliminary results. Journal of Psychosomatic Research, 65, 23–30. https://doi.org/10.1016/j.jpsychores.2008.02.003 First citation in articleCrossrefGoogle Scholar

  • Friedman, B. H. (2007). An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone. Biological Psychology, 74, 185–199. https://doi.org/10.1016/j.biopsycho.2005.08.009 First citation in articleCrossrefGoogle Scholar

  • Garbarino, S., Guglielmi, O., Sanna, A., Mancardi, G. L., & Magnavita, N. (2016). Risk of occupational accidents in workers with obstructive sleep apnea: Systematic review and meta-analysis. Sleep, 39, 1211–1218. https://doi.org/10.5665/sleep.5834 First citation in articleCrossrefGoogle Scholar

  • Garbarino, S., Guglielmi, O., Sannita, W. G., Magnavita, N., & Lanteri, P. (2018). Sleep and mental health in truck drivers: Descriptive review of the current evidence and proposal of strategies for primary prevention. International Journal of Environmental Research and Public Health, 15, 1852. https://doi.org/10.3390/ijerph15091852 First citation in articleCrossrefGoogle Scholar

  • Garbarino, S., Lanteri, P., Durando, P., Magnavita, N., & Sannita, W. G. (2016). Co-morbidity, mortality, quality of life and the healthcare/welfare/social costs of disordered sleep: A rapid review. International Journal of Environmental Research and Public Health, 13, 831. https://doi.org/10.3390/ijerph13080831 First citation in articleCrossrefGoogle Scholar

  • Garbarino, S., & Sannita, W. G. (2017). Poor sleeping has underrepresented medical, healthcare, and social costs? European Journal of Internal Medicine, 38, e15–e16. https://doi.org/10.1016/j.ejim.2016.10.020 First citation in articleCrossrefGoogle Scholar

  • Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., … Zasler, N. D. (2002). The minimally conscious state: Definition and diagnostic criteria. Neurology, 58, 349–353. First citation in articleCrossrefGoogle Scholar

  • Glos, M., Fietze, I., Blau, A., Baumann, G., & Penzel, T. (2014). Cardiac autonomic modulation and sleepiness: Physiological consequences of sleep deprivation due to 40 h of prolonged wakefulness. Physiology & Behavior, 125, 45–53. https://doi.org/10.1016/j.physbeh.2013.11.011 First citation in articleCrossrefGoogle Scholar

  • Grossman, P., & Taylor, E. W. (2007). Toward understanding respiratory sinus arrhythmia: Relations to cardiac vagal tone, evolution and biobehavioral functions. Biological Psychology, 74, 263–285. https://doi.org/10.1016/j.biopsycho.2005.11.014 First citation in articleCrossrefGoogle Scholar

  • Hagemann, D., Waldstein, S. R., & Thayer, J. F. (2003). Central and autonomic nervous system integration in emotion. Brain & Cognition, 52, 79–87. https://doi.org/10.1016/S0278-2626(03)00011-3 First citation in articleCrossrefGoogle Scholar

  • Hagenauer, M. H., Perryman, J. I., Lee, T. M., & Carskadon, M. A. (2009). Adolescent changes in the homeostatic and circadian regulation of sleep. Developmental Neuroscience, 31, 276–284. https://doi.org/10.1159/000216538 First citation in articleCrossrefGoogle Scholar

  • Hall, M., Vasko, R., Buysse, D., Ombao, H., Chen, Q., Cashmere, J. D., … Thayer, J. F. (2004). Acute stress affects heart rate variability during sleep. Psychosomatic Medicine, 66, 56–62. First citation in articleCrossrefGoogle Scholar

  • Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003). A clockwork web: Circadian timing in brain and periphery, in health and disease. Nature Reviews Neuroscience, 4, 649–661. https://doi.org/10.1038/nrn1177 First citation in articleCrossrefGoogle Scholar

  • Heraghty, J. L., Hilliard, T. N., Henderson, A. J., & Fleming, P. J. (2008). The physiology of sleep in infants. Archives of Disease in Childhood, 93, 982–985. https://doi.org/10.1136/adc.2006.113290 First citation in articleCrossrefGoogle Scholar

  • Huikuri, H. V., Kessler, K. M., Terracall, E., Castellanos, A., Linnaluoto, M. K., & Myerburg, R. J. (1990). Reproducibility and circadian rhythm of heart rate variability in healthy subjects. The American Journal of Cardiology, 65, 391–393. First citation in articleCrossrefGoogle Scholar

  • Jarczok, M. N., Aguilar-Raab, C., Koenig, J., Kaess, M., Borniger, J. C., Nelson, R. J., … Fischer, J. E. (2018). The Heart’s rhythm “n” blues: Sex differences in circadian variation patterns of vagal activity vary by depressive symptoms in predominantly healthy employees. Chronobiology International, 35, 896–909. https://doi.org/10.1080/07420528.2018.1439499 First citation in articleCrossrefGoogle Scholar

  • Jarczok, M. N., Koenig, J., Mauss, D., & Thayer, J. F. (2014). Lower heart rate variability predicts increased level of C-reactive protein 4 years later in healthy, nonsmoking adults. Journal of Internal Medicine, 276, 667–671. https://doi.org/10.1111/joim.12295 First citation in articleCrossrefGoogle Scholar

  • Jarczok, M. N., Li, J., Mauss, D., Fischer, J. E., & Thayer, J. F. (2013). Heart rate variability is associated with glycemic status after controlling for components of the metabolic syndrome. International Journal of Cardiology, 167, 855–861. https://doi.org/10.1016/j.ijcard.2012.02.002 First citation in articleCrossrefGoogle Scholar

  • Karatsoreos, I. N., & McEwen, B. S. (2014). Timing is everything: A collection on how clocks affect resilience in biological systems. F1000Research, 3, 273. https://doi.org/10.12688/f1000research.5756.1 First citation in articleCrossrefGoogle Scholar

  • Katona, P. G., & Jih, F. (1975). Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control. Journal of Applied Physiology, 39, 801–805. First citation in articleCrossrefGoogle Scholar

  • Koenig, J., & Thayer, J. F. (2016). Sex differences in healthy human heart rate variability: A meta-analysis. Neuroscience & Biobehavioral Reviews, 64, 288–310. https://doi.org/10.1016/j.neubiorev.2016.03.007 First citation in articleCrossrefGoogle Scholar

  • Kondratova, A. A., & Kondratov, R. V. (2012). The circadian clock and pathology of the ageing brain. Nature Reviews Neuroscience, 13, 325–335. https://doi.org/10.1038/nrn3208 First citation in articleCrossrefGoogle Scholar

  • Laureys, S., Celesia, G. G., Cohadon, F., Lavrijsen, J., León-Carrión, J., Sannita, W. G., … Dolce, G. (2010). Unresponsive wakefulness syndrome: A new name for the vegetative state or apallic syndrome. BMC Medicine, 8, 68. https://doi.org/10.1186/1741-7015-8-68 First citation in articleCrossrefGoogle Scholar

  • Lavie, P. (2001). Sleep disturbances in the wake of traumatic events. The New England Journal of Medicine, 345, 1825–1832. https://doi.org/10.1056/NEJMra012893 First citation in articleCrossrefGoogle Scholar

  • Levy, M. N. (1990). Autonomic interactions in cardiac control. Annals of the New York Academy of Sciences, 601, 209–221. First citation in articleCrossrefGoogle Scholar

  • Li, X., Shaffer, M. L., Rodriguez-Colon, S., He, F., Wolbrette, D. L., Alagona, P. Jr., … Liao, D. (2011). The circadian pattern of cardiac autonomic modulation in a middle-aged population. Clinical Autonomic Research, 21, 143–150. https://doi.org/10.1007/s10286-010-0112-4 First citation in articleCrossrefGoogle Scholar

  • Mahowald, M. W., & Schenck, C. H. (2005). Insights from studying human sleep disorders. Nature, 437, 1279–1285. https://doi.org/10.1038/nature04287 First citation in articleCrossrefGoogle Scholar

  • Maier, S. F., Goehler, L. E., Fleshner, M., & Watkins, L. R. (1998). The role of the vagus nerve in cytokine-to-brain communication. Annals of the New York Academy of Sciences, 840, 289–300. First citation in articleCrossrefGoogle Scholar

  • Makino, M., Hayashi, H., Takezawa, H., Hirai, M., Saito, H., & Ebihara, S. (1997). Circadian rhythms of cardiovascular functions are modulated by the baroreflex and the autonomic nervous system in the rat. Circulation, 96, 1667–1674. First citation in articleCrossrefGoogle Scholar

  • Maywood, E. S., Mrosovsky, N., Field, M. D., & Hastings, M. H. (1999). Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock. Proceedings of the National Academy of Sciences of the USA, 96, 15211–15216. First citation in articleCrossrefGoogle Scholar

  • Meerlo, P., Sgoifo, A., & Suchecki, D. (2008). Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews, 12, 197–210. https://doi.org/10.1016/j.smrv.2007.07.007 First citation in articleCrossrefGoogle Scholar

  • Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016). Diurnal variation of circulating interleukin-6 in humans: A meta-analysis. PLoS one, 11, e0165799. https://doi.org/10.1371/journal.pone.0165799 First citation in articleCrossrefGoogle Scholar

  • O’Connor, M.-F., Motivala, S. J., Valladares, E. M., Olmstead, R., & Irwin, M. R. (2007). Sex differences in monocyte expression of IL-6: Role of autonomic mechanisms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293, R145–151. https://doi.org/10.1152/ajpregu.00752.2006 First citation in articleCrossrefGoogle Scholar

  • Pagani, M., Pizzinelli, P., Traon, A. P.-L., Ferreri, C., Beltrami, S., Bareille, M.-P., … Philip, P. (2009). Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers. Autonomic Neuroscience: Basic & Clinical, 145, 76–80. https://doi.org/10.1016/j.autneu.2008.10.009 First citation in articleCrossrefGoogle Scholar

  • Pavlov, V. A., & Tracey, K. J. (2012). The vagus nerve and the inflammatory reflex-linking immunity and metabolism. Nature Reviews Endocrinology, 8, 743–754. https://doi.org/10.1038/nrendo.2012.189 First citation in articleCrossrefGoogle Scholar

  • Quintana, D. S., Elvsåshagen, T., Zak, N., Norbom, L. B., Pedersen, P. Ø., Quraishi, S. H., … Westlye, L. T. (2017). Diurnal variation and twenty-four hour sleep deprivation do not alter supine heart rate variability in healthy male young adults. PLoS One, 12, e0170921. https://doi.org/10.1371/journal.pone.0170921 First citation in articleCrossrefGoogle Scholar

  • Refinetti, R., Lissen, G. C., & Halberg, F. (2007). Procedures for numerical analysis of circadian rhythms. Biological Rhythm Research, 38, 275–325. https://doi.org/10.1080/09291010600903692 First citation in articleCrossrefGoogle Scholar

  • Riganello, F., Cortese, M. D., Arcuri, F., Dolce, G., Lucca, L., & Sannita, W. G. (2015). Autonomic nervous system and outcome after neuro-rehabiliation in disorders of consciousness. Journal of Neurotrauma, 33, 423–424. https://doi.org/10.1089/neu.2015.3906 First citation in articleCrossrefGoogle Scholar

  • Riganello, F., Dolce, G., & Sannita, W. (2012). Heart rate variability and the central autonomic network in the severe disorder of consciousness. Journal of Rehabilitation Medicine, 44, 495–501. https://doi.org/10.2340/16501977-0975 First citation in articleCrossrefGoogle Scholar

  • Riganello, F., Garbarino, S., & Sannita, W. G. (2012). Heart rate variability, homeostasis, and brain function. Journal of Psychophysiology, 26, 178–203. https://doi.org/10.1027/0269-8803/a000080 First citation in articleLinkGoogle Scholar

  • Riganello, F., Garbarino, S., & Sannita, W. (2014). Heart rate variability and the two-way interaction between CNS and the central autonomic network. Journal of Experimental & Clinical Cardiology, 9, 5584–5595. First citation in articleGoogle Scholar

  • Sannita, W. G. (2006). Individual variability, end-point effects and possible biases in electrophysiological research. Clinical Neurophysiology, 117, 2569–2583. https://doi.org/10.1016/j.clinph.2006.04.026 First citation in articleCrossrefGoogle Scholar

  • Saper, C. B., Scammell, T. E., & Lu, J. (2005). Hypothalamic regulation of sleep and circadian rhythms. Nature, 437, 1257–1263. https://doi.org/10.1038/nature04284 First citation in articleCrossrefGoogle Scholar

  • Sauvet, F., Leftheriotis, G., Gomez-Merino, D., Langrume, C., Drogou, C., Van Beers, P., … Chennaoui, M. (2010). Effect of acute sleep deprivation on vascular function in healthy subjects. Journal of Applied Physiology, 108, 68–75. https://doi.org/10.1152/japplphysiol.00851.2009 First citation in articleCrossrefGoogle Scholar

  • Siege, J. M. (2005). Clues to the functions of mammalian sleep. Nature, 437, 1264–1271. https://doi.org/10.1038/nature04285 First citation in articleCrossrefGoogle Scholar

  • Silver, R., & Kriegsfeld, L. J. (2014). Circadian rhythms have broad implications for understanding brain and behavior. European Journal of Neuroscience, 39, 1866–1880. https://doi.org/10.1111/ejn.12593 First citation in articleCrossrefGoogle Scholar

  • Spiegelhalder, K., Fuchs, L., Ladwig, J., Kyle, S. D., Nissen, C., Voderholzer, U., … Riemann, D. (2011). Heart rate and heart rate variability in subjectively reported insomnia. Journal of Sleep Research, 20, 137–145. https://doi.org/10.1111/j.1365-2869.2010.00863.x First citation in articleCrossrefGoogle Scholar

  • Stein, P. K., & Pu, Y. (2012). Heart rate variability, sleep and sleep disorders. Sleep Medicine Reviews, 16, 47–66. https://doi.org/10.1016/j.smrv.2011.02.005 First citation in articleCrossrefGoogle Scholar

  • Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation, 93, 1043–1065. First citation in articleCrossrefGoogle Scholar

  • Thayer, J. F., & Lane, R. D. (2009). Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration. Neuroscience & Biobehavioral Reviews, 33, 81–88. https://doi.org/10.1016/j.neubiorev.2008.08.004 First citation in articleCrossrefGoogle Scholar

  • Thayer, J. F., & Sternberg, E. (2006). Beyond Heart Rate Variability. Annals of the New York Academy of Sciences, 1088, 361–372. https://doi.org/10.1196/annals.1366.014 First citation in articleCrossrefGoogle Scholar

  • Tobaldini, E., Nobili, L., Strada, S., Casali, K. R., Braghiroli, A., & Montano, N. (2013). Heart rate variability in normal and pathological sleep. Frontiers in Physiology, 4, 294. https://doi.org/10.3389/fphys.2013.00294 First citation in articleCrossrefGoogle Scholar

  • Touitou, Y., Reinberg, A., & Touitou, D. (2017). Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sciences, 173, 94–106. https://doi.org/10.1016/j.lfs.2017.02.008 First citation in articleCrossrefGoogle Scholar

  • Vaara, J., Kyröläinen, H., Koivu, M., Tulppo, M., & Finni, T. (2009). The effect of 60-h sleep deprivation on cardiovascular regulation and body temperature. European Journal of Applied Physiology, 105, 439–444. https://doi.org/10.1007/s00421-008-0921-5 First citation in articleCrossrefGoogle Scholar

  • Vanoli, E., Adamson, P. B., Ba-Lin, Pinna, G. D., Lazzara, R., & Orr, W. C. (1995). Heart rate variability during specific sleep stages. A comparison of healthy subjects with patients after myocardial infarction. Circulation, 91, 1918–1922. First citation in articleCrossrefGoogle Scholar

  • Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005). IL-6 and its circadian secretion in humans. Neuroimmunomodulation, 12, 131–140. https://doi.org/10.1159/000084844 First citation in articleCrossrefGoogle Scholar

  • Wallin, B. G., & Charkoudian, N. (2007). Sympathetic neural control of integrated cardiovascular function: Insights from measurement of human sympathetic nerve activity. Muscle Nerve, 36, 595–614. https://doi.org/10.1002/mus.20831 First citation in articleCrossrefGoogle Scholar

  • Yang, A. C., Tsai, S.-J., Yang, C.-H., Kuo, C.-H., Chen, T.-J., & Hong, C.-J. (2011). Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. Journal of Affective Disorders, 131, 179–185. https://doi.org/10.1016/j.jad.2010.11.030 First citation in articleCrossrefGoogle Scholar