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Originalia

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

Published Online:September 01, 2006https://doi.org/10.1024//1016-264X.12.1.8

Abstract

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.


Dysfunktionale Reorganisation in der Entwicklung des limbo-präfrontalen Systems bei Tieren: Bedeutung für psychotische Dekompensation bei Menschen

Zusammenfassung: Die Ausweitung der experimentellen Plastizitätsforschung auf psycho-kognitive Systeme des Gehirns und der Einsatz von nichtinvasiven Methoden am Tiermodell (Meriones unguiculatus) bieten erstmalig einen Brückenschlag zur Klinischen Psychologie und zur Psychiatrie. Die restriktive versus semi-natürliche Aufzucht und der systemische Einsatz von Methamphetamin werden im Zusammenhang mit der sehr langsamen Dopaminreifung als jeweils hinreichende Induktoren einer dysfunktionalen Reorganisation im Präfrontalcortex zusätzlich einer Fehlregulation der Neurogenese im hippocampalen Dentatus beschrieben. Wege der Behandlung von psycho-kognitiven Entwicklungsstörungen erwachsen aus der Erkenntnis, daß sich diese Dyskonnektion des limbo-präfrontalen Schaltkreises über die Neurogenese (pharmakologigch/therapeutisch) als adaptiv erweist.

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