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Thrombozytäre Serotoninkonzentration bei depressiven Kindern und Jugendlichen

Published Online:September 01, 2006https://doi.org/10.1024//1422-4917.30.3.163

Abstract

Zusammenfassung:Fragestellung: In dieser Studie wurde der Frage nachgegangen, inwieweit ein Zusammenhang zwischen thrombozytärem Serotoningehalt und depressivem bzw. suizidalem Verhalten bei Kindern und Jugendlichen besteht. Methodik: Innerhalb von 16 Monaten wurde bei allen stationär aufgenommenen Patienten im Alter von 4 bis 19 Jahren (n = 145) das thrombozytäre Serotonin mittels Fluoreszenzspektroskopie bestimmt. Zeitnah wurde bei einem Teil der Patienten der Schweregrad der depressiven Symptome durch das DIKJ erhoben. Die verschiedenen Diagnosegruppen wurden anhand der Kriterien der ICD-10 gebildet. Ergebnisse: Mit zunehmendem Alter zeigte sich ein Abfall des Serotiningehaltes im Thrombozyten. Die männlichen Patienten wiesen höhere Serotoninwerte im Vergleich zu den weiblichen auf, wobei die Mädchen allerdings höhere Depressivitätsscores im DIKJ zeigten. Es bestand eine negative Korrelation zwischen dem thrombozytären Serotonin und dem im DIKJ gemessenen Depressivitätsgrad über alle Diagnosegruppen. Unabhängig von der klinischen Diagnose ergaben sich signifikant niedrigere Serotoninkonzentrationen bei den Kindern und Jugendlichen, die unmittelbar vor der stationären Aufnahme einen Suizidversuch unternommen hatten. Auch bei der Gruppe der depressiven Störungen kristallisierte sich eine Untergruppe mit signifikant niedrigerem Serotoningehalt heraus, die kurz zuvor einen Suizidversuch verübt hatten. Schlussfolgerungen: Die vorliegenden Untersuchungen stützen die Auffassung, dass Depressivität in der Kindheit und Jugend mit einem Mangel an Serotonin im Thrombozyten bzw. analog zum Thrombozytenmodell in zentralen Strukturen verbunden ist und ein relatives Defizit an Serotonin ein Suizidalitätsmarker sein könnte.


Platelet Serotonin Concentration in Depressive Children and Adolescents

Summary:Objectives: This study pursued the question to what extent a correlation exists between the platelet serotonin concentration and depressive and/or suicidal behaviour in children and adolescents. Methods: Within a 16-month period, the platelet serotonin concentration was determined in all admitted inpatients (n = 145, age: 4 to 19 years) by means of fluorescent spectroscopy according to a standardised protocol. The severity of depressive symptoms was assessed by administration of the DIKJ to a subset of patients. The different diagnostic groups were formed according to the criteria of the ICD-10. Results: A decrease in the platelet serotonin concentration was found with increasing age. While platelet serotonin concentrations were higher in male patients than in females, the girls showed higher depression scores on the DIKJ. A negative correlation existed between the platelet serotonin concentration and the degree of depression measured on the DIKJ in all diagnostic groups. Independent of the clinical diagnosis significantly lower concentrations of platelet serotonin were found in children and adolescents who had attempted suicide immediately before admission to hospital. The same is true for the group of depressive disorders, with a subgroup of patients who had attempted suicide shortly before also showing significantly lower concentrations of platelet serotonin. Conclusions: The present investigation supports the contention that depression in childhood and adolescence is related to a lack of serotonin in platelets, respectively, analogous to the platelet model, to a lack of serotonin in central structures, and that a relative serotonin deficiency could thus be an indicator of suicidal ideation.

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