Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women
Abstract
Abstract. The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case–control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017–2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz (p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.
References
1 (2013) Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 303, 30–38.
2 (1995) The biochemical basis of the neuropathy in cobalamin deficiency. Baillieres Clin Haematol. 8, 479–497.
3 (1976) Neuropathology of experimental Vitamin B12 deficiency in monkeys. Neurology. 26, 905–914.
4 (2016) Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study. Noise Health. 81, 93–97.
5 (2004) Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 80, 1689–1696.
6 (2008) Vitamin D’s role in cell proliferation and differentiation. Nutr. Rev. 66, 116–124.
7 (2016) Vitamin D receptor deficiency impairs inner ear development in zebrafish. Biochemical and Biophysical Research Communications. 478, 994–998.
8 (2010) Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth. BMC Physiology. 10, 11.
9 (1991) A review of otoacoustic emissions. J Acoust Soc Am. 89, 2027–2067.
10 (2012) Tone-burst and click-evoked otoacoustic emissions in subjects with hearing loss above 0.25, 0.5, and 1 kHz. Ear Hear. 33, 757–767.
11 (1990) A guide to the effective use of otoacoustic emissions. Ear Hear. 11, 93–105.
12 (2013) Effect of vitamin B12 deficiency on otoacoustic emissions. Acta Otorhinolaryngologica Italic. 33, 243–247.
13 (1993) Vitamin B12 deficiency in patients with chronic- tinnitus and noise-induced hearing loss. Am J Otolaryngol. 14, 94–9.
14 (2004) The effects of ‘supra-physiological’ vitamin B12 administration on temporary threshold shift. Int J Audiol. 43, 162–165.
15 (2004) The levels of vitamins A, E, B12 and folic acid in noise-induced hearing loss. Kulak Burun Bogaz Ihtis Derg. 1, 60–64.
16 (1999) Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 69, 564–571.
17 (2010) Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. J Nutr. 140, 1469–1474.
18 (2010) Age-related hearing loss, vitamin B12, and folate in the elderly. Otolaryngol Head Neck Surg. 143, 826–830.
19 (2000) Age-related hearing impairment and B vitamin status. Acta Otolaryngol. 120, 633–637.
20 (2010) A prospective study of vitamin intake and the risk of hearing loss in men. Otolaryngol Head Neck Surg. 142, 231–236.
21 (1987) Sensorineural hearing loss associated with hypoparathyroidism. Laryngoscope. 97, 1075–1079.
22 (1989) Vitamin D deficiency-a new cause of cochlear deafness. J Laryngol Otol. 9, 405–420.
23 (1989) Evaluation of vitamin D metabolism in patients with bilateral sensorineural hearing loss. Am J Otol. 10, 11–13.
24 (2008) Progressive hearing loss in mice with a mutated vitamin D receptor gene. Audiol Neurootol. 13 (4): 219–230.
25 (1987) The effect of vitamin D deficiency on the Cochlear potentials and the Perilymphatic ionized Calcium concentration of rats. Acta otolaryngol. Suppl. 435, 64–72.