Psychometrische Beurteilung der anterograden Gedächtnisstörungen beim amnestischen Syndrom
Abstract
Zusammenfassung: In die klinische Studie sind N = 118 Patienten mit amnestischem Syndrom aus 5 Diagnosegruppen (Korsakow-Syndrom, Hypoxie, SHT, vaskuläre Demenz und M. Alzheimer im Frühstadium) eingegangen. Bei der psychometrischen Untersuchung mit dem Berliner Amnesie Test (BAT) finden wir ein charakteristisches Testprofil, das durch schwer gestörtes recall, signifikant geringere Defizite beim recognition, extrem schnelles Vergessen, auffallende Enkodierungsdefizite, mnestische Interferenzen und weitgehend erhaltene Kurzzeitgedächtnisspanne gekennzeichnet ist. Bei ca. 80% der Fälle liegen sowohl verbale als auch figural-räumliche mnestische Störungen vor. Bezüglich der Mittelwertprofile der Patientengruppen können keine klinisch wesentlichen statistischen Unterschiede nachgewiesen werden. Es werden Verteilungsparameter zum amnestischen Syndrom angegeben, die zur Schätzung des Schweregrades und zur Abgrenzung von anderen Gedächtnisstörungen geeignet sind.
Abstract:N = 118 in-patients with amnesic syndrome from five different groups of diagnosis (Korsakoff's syndrome, Hypoxia, Head injury, vascular Dementia and Alzheimer's disease (early stage)) were tested by a neuropsychological test battery including the Berliner Amnesie Test (BAT). A typical profile of memory disorders characterized by heavy disturbed recall, significantly smaller deficit in familiarity based recognition, extremely rapid forgetting, remarkable encoding deficits, mnesic interferences and nearly normal short-term memory span was found. There is no essential difference between the mean values of test profiles of the included diagnostic groups. About 80% of the cases have verbal as well as figural-spatial memory disorders. Using the distribution parameters of the tested sample, it is possible to differentiate between patients with amnesic syndrome and other memory disorders and to estimate the severity of the amnesic syndrome in a quantitative way.
References
(1999). Episodic memory, amnesia, and the hippocampal-anterior thalamic axis.. Behavioural and Brain Sciences, 22, 425–489.
(1996). Amnesia and recognition memory: A re-analysis of psychometric data.. Neuropsychologia, 34, 51–62.
(2001). Preserved recognition in a case of development amnesia: Implications for the acquisition of semantic memory.. Journal of Cognitive Neuroscience, 13(3), 357–369.
(1998). Neuropsychological deficits in patients with an anterior communicating artery syndrom: A multiple case study.. Acta Neurologica Belgica, 98, 266–278.
(1981). Test d2. Aufmerksamkeits-Belastungs-Test (7.Aufl.).. Göttingen: Hogrefe. .
(1988). Modelling dementia: Effects of scopolamine on memory and attention.. Neuropsychologia, 26, 685–700.
(1980). Alcoholic Korsakoff's syndrom: An information processing approach.. New York: Academic Press. .
(1994). Pure amnesia after unilateral left polar thalamic infarct: Topographic and sequential neuropsychological and metabolic (PET) correlations.. Journal of Neurology, Neurosurgery and Psychiatrie, 57, 27–34.
(2000). Internationale Klassifikation psychischer Störungen. Diagnostische Kriterien für Forschung und Praxis (2.Aufl.).. Bern: Huber. .
(2002). Temporal order memory in patients with Korsakoff syndrome and medial temporal amnesia.. Neuropsychologia, 40, 853–861.
(1993). Wisconsin Card Sorting Test Manual (Revised and Expanded).. Odessa, FL: PAR Psychological Assessment Resources, Inc. .
(2000). Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia.. Brain, 123, 141–154.
(1997). Free recall and recognition in a network model of the hippocampus.. Behavioral Brain Research, 89, 1–34.
(1988). Recall and recognition memory in patients with Alzheimer's and Parkinson's disease.. Annuals of Neurology, 24, 214–217.
(1983). Leistungsprüfsystem (LPS).. Göttingen: Hogrefe. .
(1994). Etiological variation in the amnesic syndrome: Comparisons using the temporal list discrimination task.. Neuropsychologia, 32, 819–826.
(1991). A process dissociation framework: Separating automatic from intentional uses of memory.. Journal of Memory and Language, 30, 513–541.
(1999). Episodic memory, amnesia, and hippocampus. - Neuropsychological assumptions and implications.. Behavioral and brain Sciences, 22, 454– .
(2002). Anterograde and retrograde amnesia following frontal lobe, temporal lobe, or diencephalic lesions.. In L.R. Squire & D.L. Schacter (Eds.), Neuropsychology of memory (3rd ed.) (pp.47-60). New York: Guilford. .
(1998). Forgetting rates in neuropsychiatric disorders.. Journal of Neurology, Neurosurgery and Psychiatry, 65, 890–898.
(1994). Neuropsychological assessment.. New York: Oxford University Press. .
(1980). Recognizing: The judgment of a previous occurrence.. Psychological Review, 27, 252–271.
(1999). Gedächtnisstörungen.. Stuttgart: Kohlhammer. .
(1992). Equivalent forgetting rates in long-term memory for diencephalic and medial temporal lobe amnesia.. Journal of Neuroscience, 12, 3765–3772.
(1991). Zur Konstruktion klinisch psychologischer Tests, Darstellung einer Validierungsmethodik am Beispiel des Berliner Amnesie Tests (BAT).. Diagnostica, 37, 109–119.
(1998). Neuropsychologische Diagnostik und Behandlung einer Patientin mit amnestischen Syndrom.. In K.D. Kubinger & H. Teichmann (Hrsg.), Psychologische Diagnostik und Intervention in Fallbeispielen (S.221-230). Weinheim: Beltz Psychologie Verlags Union. .
(2000). Standardisierte Link'sche Probe (SLP) zur Beurteilung exekutiver Funktionen.. Frankfurt: SWETS Test Services. .
(2002). Gedächtnisstörungen nach unilateralen zerebralen Läsionen.. Nervenarzt, 73, 355–363.
(1992). Der Berliner Amnesie Test.. Göttingen: Hogrefe. .
(1997). Hierarchical organization of cognitive memory.. Philosophical Transaction of the Royal Society of London - Series B: Biological Sciences, 352, 1461–1467.
(2002). Hypoxisch-ischämische Enzephalopathie.. Akta Neurologica, 29, 431–446.
(1997). Memory consolidation, retrograd amnesia and hippocampal complex.. Current Opinion in Neurobiology, 7, 431–139.
(1993). Unilateral amnesic stroke.. Stroke , 24, 1033–1042.
(2000). Erinnern und Vergessen.. Bern: Huber. .
(1993). Neuropsychology of the Amnesic Syndrome.. Hillsdale, NJ: Erlbaum. .
(1997). Impaired recognition memory in patients with lesions limited to the hippocampal formation.. Behavioral Neuroscience, 111, 667–675.
(1992). Trail Making Test.. Tucson: Reitan Neuropsychology Laboratory. .
(1993). Birmingham Object Recognition Battery (BORB).. Hillsdale, NJ: Erlbaum. .
(1992). Wortschatztest (WST).. Weinheim: Beltz. .
(1997). Verhaltensneurologie. Die neurologische Seite der Neuropsychologie.. New York: Thieme. .
(2000). Gedächtnisstörungen.. In W. Sturm, M. Herrmann & C.-W. Wallesch (Hrsg.), Lehrbuch der klinischen Neuropsychologie (S.375-391). Frankfurt: Swets & Zeitlinger. .
(1996). Memory disorders.. In T. Brandt, L.R. Caplan, J. Dichgans, H.C. Diener & C. Kennard (Eds.), Neurological disorders: Course and treatment (pp.223-230). San Diego: Academic Press. .
(2002). Relational binding theory and the role of consolidation in memory retrieval.. In L.R. Squire & D.L. Schacter (Eds.), Neuropsychology of memory (3rd ed., pp.61-72). New York: Guilford. .
(2001). Hippocampal amnesia.. Neurocase, (2001), 357–382.
(1984). The medial temporal region and memory consolidation.. In H. Weingartner & E.S. Parker (Eds.), Memory consolidation: Psychology of cognition (pp.185-210). Hillsdale, NJ: Erlbaum. .
(2001). Dissociations in cognitive memory: The syndrome of developmental amnesia.. Philosophical Transaction of the Royal Society of London - Series B: Biological Science, 356(1413), 1435–1440.
(2000). A neuropsychological analysis of memory and amnesia.. Seminars in Neurology, 20, 455–462.
(2002). Impaired and preserved memory processes in amnesia.. In L.R. Squire & D.L. Schacter (Eds.), Neuropsychology of memory (3rd ed., pp.35-46). New York: Guilford. .
(1971). The Wernicke-Korsakoff-Syndrome. Contemporary neurology Series No.7.. Philadelphia: F.A. Davies. .
(1982). Amnesia: A disconnection syndrome?. Neuropsychologia, 20, 233– 248.
(1986). Wechsler Adult Intelligence Scale (WAIS).. Göttingen: Hogrefe. .
(1982). Determinate of memory failure in dementia.. In S. Corkin, K.L. Davis, J.H. Growdon, E. Usdin & R.J. Wurtman (Eds.), Aging. Vol.19: Alzheimer disease: A report of progress (pp.171-176). New York: Raven. .
(1986). Psychologische Leistungstests in der Neurologie und Psychiatrie.. Leipzig: Thieme Verlag. .
(1993). Testbatterie zur Aufmerksamkeitsprüfung (TAP).. Würselen: Psytest. .
(1999). Remembering the Hippocampus (Kommentar zu Aggleton, Brown).. Behavioural and Brain Sciences, 22, 469–471.