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Originalartikel

Differentialdiagnostischer Nutzen der CERAD neuropsychologischen Testbatterie für Patienten mit leichter kognitiver Störung mit und ohne depressiver Symptomatik: Eine retrospektive Studie

Published Online:June 03, 2015https://doi.org/10.1024/1016-264X/a000150

Abstract

Das Hauptziel dieser retrospektiven Studie war die Untersuchung des differentialdiagnostischen Nutzens der CERAD neuropsychologischen Testbatterie zur Unterscheidung geriatrischer Patienten mit leichter kognitiver Störung/MCI (n = 345) mit versus ohne depressiver Symptomatik. Alle Analysen wurden doppelt gerechnet (ICD-10-konforme MCI-Definition und amnestische MCI/a-MCI). Die optimalen empirischen Cutoff-Werte und die diagnostische Genauigkeit wurden mittels Receiver Operating Characteristic/ROC-Analysen berechnet.

Die Ergebnisse sind abhängig vom verwendeten MCI-Definitionskriterium und bestätigen die differentialdiagnostische Nützlichkeit der CERAD, allerdings ausschließlich bei Verwendung ICD-10-konformer Definitionskriterien (nicht bei a-MCI). Der CERAD-Summenwert differenziert signifikant zwischen MCI-Patienten mit versus ohne depressiver Symptomatik (AUC = .634, p < .001), wobei die diagnostische Genauigkeit (61 %) insgesamt als gering einzustufen ist.


About the Differential Diagnostic Utility of the CERAD Neuropsychological Assessment Battery in Patients with Mild Cognitive Impairment with and without Depressive Symptomatology: A Retrospective Study

The main aim of the present retrospective study was to investigate whether the CERAD neuropsychological battery may differentiate between geriatric patients with minimal cognitive impairment/MCI (n = 345) with/without depressive symptomatology. Data analyses rested on two popular yet distinct MCI-definitions (ICD-10 and amnestic MCI/a-MCI). Receiver operating characteristic/ROC-analyses were performed to identify the optimal empirical cutoff-values and the diagnostic accuracies of the CERAD total score.

Results support the CERAD’s usefulness for differential diagnosis, provided MCI-diagnosis is based upon the ICD-10 (rather than a-MCI) criteria. The CERAD total score differentiates significantly between MCI-patients with/without depressive symptomatology (AUC = .634, p < .001). Nonetheless, results should be interpreted cautiously as diagnostic accuracies were rather modest (61 %).

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