Skip to main content
Übersichtsarbeit

Nicht-suizidales selbstverletzendes Verhalten (NSSV) im Jugendalter: Klinische Leitlinie zur Diagnostik und Therapie

Published Online:https://doi.org/10.1024/1422-4917/a000463

Zusammenfassung.Hintergrund: Nicht-suizidales selbstverletzendes Verhalten (NSSV) ist ein häufiges, klinisch relevantes Phänomen im Jugendalter, das sich in Zusammenhang mit verschiedenen psychischen Störungen beobachten lässt. Deutschland gehört mit einer Lebenszeitprävalenz von 25–35 % bei Jugendlichen innerhalb Europas zu den Ländern mit den höchsten Prävalenzraten an NSSV. Bislang existierte eine zuletzt im Jahr 2006 überarbeitete AWMF-Leitlinie zu selbstverletzendem Verhalten und stereotypen Bewegungsstörungen, deren Gültigkeit 2011 abgelaufen war.

Methoden: Die Leitliniengruppe setzte sich aus elf medizinisch, psychologisch bzw. psychotherapeutischen Fachgesellschaften und zwei Interessensvertretungen aus Angehörigen- bzw. Präventionsprojekten zusammen. Die Leitlinie wurde in zwei Konferenzen, darauf aufbauenden Literaturrecherchen und einer abschließenden Konsensuskonferenz erarbeitet. Der Algorithmus wurde in drei Delphi-Runden verabschiedet.

Ergebnisse: Während die Datenlage zur Epidemiologie und zur Diagnostik von NSSV gut ist, sind noch immer wenige Studien zum Langzeitverlauf und zur psychotherapeutischen sowie zum Stellenwert einer psychopharmakologischen, adjuvanten Behandlung von NSSV im Jugendalter verfügbar. Berufsgruppenübergreifend wurde auch das Vorgehen im Falle der Notwendigkeit einer somatischen Versorgung bei NSSV thematisiert.

Schlussfolgerungen: In Anbetracht der heterogenen Evidenzlage wurden, um die klinische Anwendbarkeit der Leitlinie zu gewährleisten, die wesentlichen Punkte zur Behandlung von NSSV im Jugendalter in einer Konsensuskonferenz abgestimmt. Forschungsdefizite zeigen sich sowohl im Bereich präventiver als auch klinischer Interventionen.


Nonsuicidal self-injury in adolescence: a clinical guideline for diagnostics and therapy

Abstract.Objective: Nonsuicidal self-injury (NSSI) is a frequent, clinically relevant phenomenon occurring in adolescence, which can be observed parallel to various mental disorders. Within Europe, Germany has one of the highest prevalence rates in youths, with the lifetime prevalence ranging between 25–35 %. To date a guideline on the treatment of self-injury and stereotypic motoric disorders has been available, the last having been updated in 2006 and expired in 2011. Methods: The guideline development group consisted of members of 11 medical, psychological, or psychotherapeutic professional associations and two members from patient and prevention groups. The guideline was developed in two meetings followed up by consecutive literature searches; it was adopted in a final consensus conference. The algorithm on the treatment of NSSI was approved in three rounds of a Delphi process. Results: Although there is solid evidence of NSSI from the fields of epidemiology and diagnostics, few studies report data on the longitudinal course as well as on the psychotherapeutic and adjuvant psychopharmacological treatment of NSSI in adolescence. The stepped care regimens in cases demanding somatic treatment were addressed interdisciplinarily. Conclusions: In accordance with the heterogeneous evidence, important points for the treatment of NSSI in adolescence were determined in a consensus conference. There is still a lack of knowledge on prevention as well as clinical interventions, both of which need to be addressed by further research.

Keywords: nonsuicidal self-injury, NSSI, self-harm, adolescents, guideline, therapy

Literatur

  • Allroggen, M., Kleinrahm, R., Rau, T. A. D., Weninger, L., Ludolph, A. G. & Plener, P. L. (2014). Non-Suicidal Self-Injury (NSSI) and its relation to personality traits in medical students. The Journal of Nervous and Mental Disease, 202, 300–304. First citation in articleCrossref MedlineGoogle Scholar

  • American Psychiatric Association (APA) (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington: American Psychiatric Association. First citation in articleCrossrefGoogle Scholar

  • Andover, M. S., Morris, B. W., Wren, A. & Bruzzese, M. E. (2012). The co-occurrence of non-suicidal self injury and attempted suicide among adolescents: Distinguishing risk factors and psychosocial correlates. Child and Adolescent Psychiatry and Mental Health, 6, 11. First citation in articleMedlineGoogle Scholar

  • Bonenberger, M., Plener, P. L., Groschwitz, R. C., Grön, G. & Abler, B. (2015). Differential neural processing of unpleasant haptic sensations in somatic and affective partitions of the insula in Non-Suicidal Self-Injury (NSSI). Psychiatry Research: Neuroimaging, 234, 298–304. First citation in articleCrossref MedlineGoogle Scholar

  • Bowes, L., Carnegie, R., Pearson, R., Mars, B., Biddle, L., Maughan, B., … Heron, J. (2015). Risk of depression and self-harm in teenagers identifying with goth subculture: a longitudinal cohort study. The Lancet Psychiatry, 2, 793–800. First citation in articleCrossref MedlineGoogle Scholar

  • Brent, D. A., Emslie, G. J., Clarke, G. N., Asarnow, J., Spirito, A., Ritz, L., … Keller, M. B. (2009). Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study. The American Journal of Psychiatry, 166, 418–426. First citation in articleCrossref MedlineGoogle Scholar

  • Bresin, K. & Schoenleber, M. (2015). Gender differences in the prevalence of nonsuicidal self-injury: A meta-analysis. Clinical Psychology Review, 38, 55–64. First citation in articleCrossref MedlineGoogle Scholar

  • Brunner, R., Kaess, M., Parzer, P., Fischer, G., Carli, V., Hoven, C. W., … Wasserman, D. (2014). Life-time prevalence and psychosocial correlates of adolescent direct self-injurious behavior: a comparative study of findings in 11 European countries. Journal of Child Psychology and Psychiatry, 55, 337–348. First citation in articleCrossref MedlineGoogle Scholar

  • Brunstein Klomek, A., Snir, A., Apter, A., Carli, V., Wasserman, C., Hadlaczky, G., … Wasserman, D. (2016). Association between victimization by bullying and direct self injurious behavior among adolescence in Europe: a ten-country study. European Child and Adolescent Psychiatry, DOI: 10.1007/s00787-016-0840-7. First citation in articleMedlineGoogle Scholar

  • Chanen, A. M., Jackson, H. J. & McCutcheon, L. K. (2008). Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: randomised controlled trial. The British Journal of Psychiatry, 193, 477–484. First citation in articleCrossref MedlineGoogle Scholar

  • Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (DGKJP) (2016). Leitlinie Nicht-Suizidales Selbstverletzendes Verhalten (NSSV) im Kindes- und Jugendalter. Download unter: http://www.awmf.org/uploads/tx_szleitlinien/028-029l_S2k_Nicht-suizidales-selbstverletzendes_Verhalten_NSSV_2016-04.pdf (eingesehen am 02.06.2016). First citation in articleGoogle Scholar

  • Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (DGKJP) (Hrsg.). (2007). Selbstverletzendes Verhalten und stereotype Bewegungsstörungen. In: Leitlinien zur Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter. (3. Aufl., 379–391). Köln: Deutscher Ärzte Verlag. First citation in articleGoogle Scholar

  • Fegert, J. M. & Plener, P. L. (2005) Self-Harm Inventory – deutsch. In: Petermann, F., Winkel S.: Selbstverletzendes Verhalten. Göttingen: Hogrefe Verlag. First citation in articleGoogle Scholar

  • Fischer, G., Ameis, N., Parzer, P., Plener, P. L., Groschwitz, R. C., Vonderlin, E., … Kaess, M. (2014). The German version of the self-injurious thoughts and behaviors interview (SITBI-G): a tool to assess non-suicidal self-injury and suicidal behavior disorder. BMC Psychiatry, 14, 265. First citation in articleMedlineGoogle Scholar

  • Fischer, G., Brunner, R., Parzer, P., Resch, F. & Kaess, M. (2013). Short-term psychotherapeutic treatment in adolescents engaging in non-suicidal self-injury: a randomized controlled trial. Trials, 14, 294. First citation in articleGoogle Scholar

  • Fleischhaker, C., Böhme, R., Sixt, B., Brück, C., Schneider, C. & Schulz, E. (2011). Dialectical Behavioral Therapy for Adolescents (DBT-A): a clinical trial for patients with suicidal and self-injurious behavior and borderline symptoms with a one-year Follow-up. Child and Adolescent Psychiatry and Mental Health, 5, 3. First citation in articleMedlineGoogle Scholar

  • Fliege, H., Kocalevent, R. D., Walter, O. B., Beck, S., Gratz K. L., Gutierez P. M. & Klapp, B. F. (2006). Three assessment tools for deliberate self-harm and suicide behavior: evaluation and psychopathological correlates. Journal of Psychosomatic Research, 61, 113–121. First citation in articleCrossref MedlineGoogle Scholar

  • Gratz, K. L. (2001). Measurement of deliberate self-harm: preliminary data on the deliberate self-harm inventory. Journal of Psychopathology and Behavioral Assessment, 2, 253–263. First citation in articleCrossrefGoogle Scholar

  • Groschwitz, R. C., Plener, P. L., Schumacher, T., Stoehr, R., Kaess, M. & Boege, I. (2015). The situation of former adolescent self-injurers as young adults: A follow-up study. BMC Psychiatry, 15, 160. First citation in articleMedlineGoogle Scholar

  • Groschwitz, R. C. & Plener, P. L. (2013). Psychotherapie von nicht-suizidalem selbstverletzendem Verhalten (NSSV): ein systematischer Review. Nervenheilkunde, 32, 30–37. First citation in articleGoogle Scholar

  • Groschwitz, R. C. & Plener, P. L. (2012). The neurobiology of Non-Suicidal Self-Injury (NSSI): a review. Suicidology Online, 3, 24–32. First citation in articleGoogle Scholar

  • Gutierrez, P. M., Osman, A., Barrios, F. X. & Kopper, B. A. (2001). Development and initial validation of the self-harm behaviour questionnaire. Journal of Personality Assessment, 77, 475–490. First citation in articleCrossref MedlineGoogle Scholar

  • Hankin, B. L. & Abela, J. R. (2011). Nonsuicidal self-injury in adolescence: prospective rates and risk factors in a 2½ year longitudinal study. Psychiatry Research, 186, 65–70. First citation in articleCrossref MedlineGoogle Scholar

  • Hawton, K., Bergen, H., Cooper, J., Turnbull, P., Waters, K., Ness, J. & Kapur, N. (2015). Suicide following self-harm: findings from the Multicentre Study of self-harm in England, 2000–2012. Journal of Affective Disorders, 175, 147–151. First citation in articleCrossref MedlineGoogle Scholar

  • Hibbeler, B. (2015). Nicht alltagstauglich? Deutsches Ärzteblatt, 112, A2147. First citation in articleGoogle Scholar

  • In-Albon, T., Plener, P. L., Brunner, R. & Kaess, M. (2015). Selbstverletzendes Verhalten. Leitfaden Kinder- und Jugendpsychotherapie. Göttingen: Hogrefe. First citation in articleGoogle Scholar

  • In-Albon, T., Ruf, C. & Schmid, M. (2013). Proposed Diagnostic Criteria for the DSM-5 of Nonsuicidal Self-Injury in Female Adolescents: Diagnostic and Clinical Correlates. Psychiatry Journal, DOI: 10.1155/2013/159208. 2013, 159–208. First citation in articleGoogle Scholar

  • Jarvi, S., Jackson, B., Swenson, L. & Crawford, H. (2013). The impact of social contagion on non-suicidal self-injury: a review of the literature. Archives of Suicide Research, 17, 1–19. First citation in articleCrossref MedlineGoogle Scholar

  • Kaess, M., Hille, M., Parzer, P., Maser-Gluth, C., Resch, F. & Brunner, R. (2012). Alterations in the neuroendocrinological stress response to acute psychosocial stress in adolescents engaging in nonsuicidal self-injury. Psychoneuroendocrinoly, 37, 157–161. First citation in articleCrossref MedlineGoogle Scholar

  • Kaess, M., Parzer, P., Mattern, M., Plener, P. L., Bifulco, A., Resch, F. & Brunner, R. (2013). Adverse childhood experiences and their impact on frequency, severity, and the individual function of nonsuicidal self-injury in youth. Journal of Psychiatric Research, 206, 265–272. First citation in articleCrossrefGoogle Scholar

  • Klonsky, E. D. & Moyer, A. (2008). Childhood sexual abuse and non-suicidal self-injury: meta-analysis. The British Journal of Psychiatry, 192, 166–170. First citation in articleCrossref MedlineGoogle Scholar

  • Koenig, J., Thayer, J. F. & Kaess, M. (2016). A meta-analysis on pain sensitivity in self-injury. Psychological Medicine, 46, 1597–1612. First citation in articleCrossref MedlineGoogle Scholar

  • Kopp, I. B. & Rahn, K. H. (2015). Leitlinien in der klinischen Praxis: Erkennen worauf es ankommt. Bayrisches Ärzteblatt, 1–2, 8–12. First citation in articleGoogle Scholar

  • Lereya, S. T., Winsper, C., Heron, J., Lewis, G., Gunnell, D., Fisher, H. L. & Wolke, D. (2013). Being bullied during childhood and the prospective pathways to self-harm in late adolescence. Journal of the American Academy of Child & Adolescent Psychiatry, 52, 608–618. First citation in articleCrossref MedlineGoogle Scholar

  • Lloyd, E., Kelley, M. L. & Hope, T. (1997). Self-mutilation in a community sample of adolescents: descriptive characteristics and provisional prevalence rates. Paper presented at the Annual Meeting of the Society for Behavioral Medicine, New Orleans. First citation in articleGoogle Scholar

  • Ludäscher, P., Greffrath, W., Schmahl, C., Kleindienst, N., Kraus, A., Baumgärtner, U., … Bohus, M. (2009). A cross-sectional investigation of discontinuation of self-injury and normalizing pain perception in patients with borderline personality disorder. Acta Psychiatrica Scandinavica, 120, 62–70. First citation in articleMedlineGoogle Scholar

  • Ludäscher, P., von Kalckreuth, C., Parzer, P., Kaess, M., Resch, F., Bohus, M., … Brunner, R. (2015). Pain perception in female adolescents with borderline personality disorder. European Child and Adolescent Psychiatry, 24, 351–357. First citation in articleMedlineGoogle Scholar

  • Maniglio, R. (2011). The role of child sexual abuse in the etiology of suicide and non-suicidal self-injury. Acta Psychiatrica Scandinavica, 124, 30–41. First citation in articleCrossref MedlineGoogle Scholar

  • Mehlum, L., Ramberg, M., Tørmoen, A.J., Haga, E., Diep, L. M., Stanley, B. H., … Grøholt, B. (2016). Dialectical behavior therapy compared with enhanced usual care for adolescents with repeated suicidal and self-harming behavior: Outcomes over a one-year follow-up. Journal of the American Academy of Child & Adolescent Psychiatry, 55, 295–300. First citation in articleCrossref MedlineGoogle Scholar

  • Moran, P., Coffey, C., Romaniuk, H., Olsson, C., Borschmann, R., Carlin, J. B. & Patton, G. C. (2012). The natural history of self-harm from adolescence to young adulthood: a population-based cohort study. The Lancet, 379, 236–243. First citation in articleCrossref MedlineGoogle Scholar

  • Muehlenkamp, J. J., Claes, L., Havertape, L. & Plener, P. L. (2012). International prevalence of adolescent non-suicidal self-injury and deliberate self harm. Child and Adolescent Psychiatry and Mental Health, 6, 10. First citation in articleMedlineGoogle Scholar

  • Muehlenkamp, J. J., Kerr, P. L., Bradley, A. R. & Larsen, M. A. (2010). Abuse subtypes and nonsuicidal self-injury: preliminary evidence of complex emotion regulation patterns. Journal of Nervous and Mental Disease, 198, 258–263. First citation in articleCrossref MedlineGoogle Scholar

  • Nakar, O., Brunner, R., Schilling, O., Chanen, A., Fischer, G., Parzer, P., … Kaess, M. (2016). Developmental trajectories of self-injurious behavior, suicidal behavior and substance misuse and their association with adolescent borderline personality pathology. Journal of Affective Disorders, 197, 231–238. First citation in articleCrossref MedlineGoogle Scholar

  • Nast, A., Sporbeck, B., Jacobs, A., Erdmann, R., Roll, S., Sauerland, U. & Rosumeck, S. (2013). Wahrnehmung der Verbindlichkeit von Leitlinienempfehlungen. Deutsches Ärzteblatt, 110, 663–668. First citation in articleGoogle Scholar

  • Nitkowski, D. & Petermann, F. (2011). Selbstverletzendes Verhalten und komorbide psychische Störungen: ein Überblick. Fortschritte der Neurologie Psychiatrie, 79, 9–20. First citation in articleCrossref MedlineGoogle Scholar

  • Nixon, M. K., Levesque, C., Preyde, M., Vanderkooy, J. & Cloutier, P. F. (2015). The Ottawa Self-Injury Inventory: Evaluation of an assessment measure of nonsuicidal self-injury in an inpatient sample of adolescents. Child and Adolescent Psychiatry and Mental Health, 9, 26. First citation in articleMedlineGoogle Scholar

  • Nock, M. K., Holmberg, E. B., Photos, V. I. & Michel, B. D. (2007). The Self-Injurious Thoughts and Behaviors Interview: Development, reliability, and validity in an adolescent sample. Psychological Assessment, 19, 309–317. First citation in articleCrossref MedlineGoogle Scholar

  • Nock, M. K. (2010). Self-injury. Annual Review of Clinical Psychology, 6, 339–363. First citation in articleCrossref MedlineGoogle Scholar

  • Ougrin, D., Tranah, T., Stahl, D., Moran, P. & Asarnow, J. R. (2015). Therapeutic interventions for suicide attempts and self-harm in adolescents: systematic review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 54, 97–107. First citation in articleCrossref MedlineGoogle Scholar

  • Plener, P. L., Brunner, R., Resch, F., Fegert, J. M. & Libal, G. (2010). Selbstverletzendes Verhalten im Jugendalter. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 38, 77–89. First citation in articleLinkGoogle Scholar

  • Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G. & Lulé, D. (2012). to excitement: adolescent females with Non-suicidal Self-Injury (NSSI) show changed cortical pattern to emotional and NSSI related material. Psychiatry Research: Neuroimaging, 203, 146–152. First citation in articleCrossref MedlineGoogle Scholar

  • Plener, P. L., Fischer, C. J., In-Albon, T., Rollett, B., Nixon, M. K., Groschwitz, R. C. & Schmid, M. (2013). Adolescent non-suicidal self-injury (NSSI) in German-speaking countries: comparing prevalence rates from three community samples. Social Psychiatry and Psychiatric Epidemiology, 48, 1439–1445. First citation in articleCrossref MedlineGoogle Scholar

  • Plener, P. L., Kapusta, N. D., Brunner, R. & Kaess, M. (2014). Nicht-suizidales selbstverletzendes Verhalten (NSSV) und suizidale Verhaltensstörung (SVS) im DSM-5. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 42, 405–413. First citation in articleLinkGoogle Scholar

  • Plener, P. L., Libal, G., Fegert, J. M. & Kölch, M. G. (2013). Psychopharmakologische Behandlung von nicht-suizidalem selbstverletzendem Verhalten (NSSV). Nervenheilkunde, 32, 38–45. First citation in articleGoogle Scholar

  • Plener, P. L., Libal, G., Keller, F., Fegert, J. M. & Muehlenkamp, J. J. (2009) An international comparison of adolescent non-suicidal self-injury (NSSI) and suicide attempts: Germany and the USA. Psychological Medicine, 39, 1549–1558. First citation in articleCrossref MedlineGoogle Scholar

  • Plener, P. L., Schuhmacher, T., Munz, L. M. & Groschwitz, R. C. (2015). The longitudinal course of non-suicidal self-injury and deliberate self-harm: searching for predictors. A systematic review of the literature. Borderline Personality Disorder and Emotion Dysregulation, 2, 2. First citation in articleMedlineGoogle Scholar

  • Reitz, S., Kluetsch, R., Niedtfeld, I., Knorz, T., Lis, S., Paret, C., … Schmahl, C. (2015). Incision and stress regulation in borderline personality disorder: neurobiological mechanisms of self-injurious behaviour. The British Journal of Psychiatry, 207, 165–172. First citation in articleCrossref MedlineGoogle Scholar

  • Remschmidt, H., Schmidt, M. & Poustka, F. (Hrsg.). (2012). Multiaxiales Klassifikationsschema für psychische Störungen des Kindes- und Jugendalters nach ICD-10 der WHO (6. korr. Aufl.). Bern: Verlag Hans Huber, Hogrefe. First citation in articleGoogle Scholar

  • Rossouw, T. I. & Fonagy, P. (2012). Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 1304–1313. First citation in articleCrossref MedlineGoogle Scholar

  • Rothschild, A. J., Shindul-Rothschild, J. A., Viguera, A., Murray, M. & Brewster, S. (2000). Comparison of the frequency of behavioural disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients. Journal of Clinical Psychopharmacology, 20, 7–11. First citation in articleCrossref MedlineGoogle Scholar

  • Sansone, R. A., Wiederman, M. W. & Sansone, L. A. (1998). The Self-Harm Inventory (SHI): development of a scale for identifying self-destructive behaviors and borderline personality disorder. Journal of Clinical Psychology, 54, 973–983. First citation in articleCrossref MedlineGoogle Scholar

  • Schmahl, C., Bohus, M., Esposito, F., Treede, R. D., Di Salle, F., Greffrath, W., … Seifritz, E. (2006). Neural correlates of antinociception in borderline personality disorder. Archives of General Psychiatry, 63, 659–667. First citation in articleCrossref MedlineGoogle Scholar

  • Stanley, B., Sher, L., Wilson, S., Ekman, R., Huang, Y. & Mann, J. J. (2010). Non-suicidal self injurious behaviour, endogenous opioids and monoamine neurotransmitters. Journal of Affective Disorders, 124, 134–140. First citation in articleCrossref MedlineGoogle Scholar

  • Swannell, S. V., Martin, G. E., Page, A., Hasking, P. & St John, N. J. (2014). Prevalence of nonsuicidal self-injury in nonclinical samples: systematic review, meta-analysis and meta-regression. Suicide and Life-Threatening Behavior, 44, 273–303. First citation in articleCrossref MedlineGoogle Scholar

  • Taylor, L. M. W., Oldershaw, A., Richards, C., Davidson, K., Schmidt, U. & Simic, M. (2011). Development and pilot evaluation of a manualized cognitive-behavioural treatment package for adolescent self-harm. Behavioural and Cognitive Psychotherapy, 39, 619–625. First citation in articleCrossref MedlineGoogle Scholar

  • Tschan, T., Schmid, M. & In-Albon, T. (2015). Parenting behavior in families of female adolescents with nonsuicidal self-injury in comparison to a clinical and a nonclinical control group. Child and Adolescent Psychiatry and Mental Health, 9, 1–9. First citation in articleMedlineGoogle Scholar

  • Yates, T. M., Carlson, E. A. & Egeland, B. (2008). A prospective study of child maltreatment and self-injurious behaviour in a community sample. Development and Psychopathology, 20, 651–671. First citation in articleCrossref MedlineGoogle Scholar

  • Young, R., Sproeber, N., Groschwitz, R. C., Preiss, M. & Plener, P. L. (2014). Why alternative teenagers self-harm: exploring the link between non-suicidal self-injury, attempted suicide and adolescent identity. BMC Psychiatry, 14, 137. First citation in articleGoogle Scholar