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Freier Beitrag/Free Article

Stehen kognitive Funktionen im Zusammenhang mit Angst, Depression und Posttraumatischer Belastungsstörung bei Brustkrebspatientinnen nach onkologischer Behandlung?

Published Online:February 28, 2015https://doi.org/10.1024/1661-4747.57.1.33

Abstract

Die in mehreren Studien gefundenen kognitiven Störungen bei Tumorpatienten nach Chemotherapie werden zumeist mit der Zytostatikaneurotoxizität assoziiert. In der vorliegenden Arbeit wird der Zusammenhang von Angst, Depression und Posttraumatischer Belastungsstörung mit der kognitiven Leistungsfähigkeit bei Frauen mit Mammakarzinom untersucht. Insgesamt wurden 76 Brustkrebspatientinnen fünf Jahre nach Abschluss der onkologischen Behandlung mit neuropsychologischen Testverfahren sowie mit der Hospital Anxiety and Depression Scale – Deutsche Version (HADS-D) und der Posttraumatic Stress Disorder Checklist – Civilian Version (PCL-C) untersucht: 23 nach Standard- und 24 nach Hochdosistherapie sowie 29 nach Brustoperation und Strahlentherapie als Vergleichsgruppe. Signifikante Zusammenhänge sind vor allem zwischen kognitiven Funktionen und Intrusionssymptomen einer Posttraumatischen Belastungsstörung (PTBS) festzustellen. Bei Patientinnen nach Standardtherapie weisen Intrusionen der PTBS einen moderaten Zusammenhang mit der globalen kognitiven Beeinträchtigung auf. Die Ergebnisse der Studie deuten auf multidimensionale Einfluss- und moderierende Faktoren bei der Entwicklung kognitiver Defizite bei Brustkrebspatientinnen nach onkologischer Therapie hin.


Is Cognitive Performance Associated with Anxiety, Depression, and Posttraumatic Stress Disorder in Breast Cancer Survivors After Oncologic Therapy?

Neuropsychological impairment in cancer patients after chemotherapy is frequently associated with cytostatic neurotoxicity. The present study investigates the association between anxiety, depression and posttraumatic stress disorder with cognitive performance in breast cancer patients. 76 breast carcinoma survivors five years following oncologic therapy underwent neuropsychological assessment and filled out the Hospital Anxiety and Depression Scale – German Version (HADS-D) and the Posttraumatic Stress Disorder Checklist – Civilian Version (PCL-C): 23 following standard chemotherapy, 24 following high-dose chemotherapy and 29 following surgery and radiation therapy as comparison group. Significant correlations were mostly observed between cognitive functions and a symptom of posttraumatic stress disorder-intrusion. In the standard-group we found a moderate association between posttraumatic intrusion and global cognitive impairment. The results of this study indicate that the development of cognitive dysfunctions in breast cancer patients after chemotherapy might be a multidimensional process comprising several mediating or moderating factors.

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