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CME-Beitrag, CME Article

Compliance-Aufbau im Fokus der Schizophreniebehandlung

Published Online:February 28, 2015https://doi.org/10.1024/1661-4747/a000016

Abstract

Mangelnde Pharmakotherapie-Compliance ist nach wie vor und trotz Einführung der atypischen Antipsychotika mit einem wesentlich günstigeren Wirkungs-/Nebenwirkungsprofil als das der typischen Antipsychotika eines der zentralsten Probleme der gegenwärtigen Versorgung schizophrener Störungen. Die Lücke zwischen Effektivität und Nutzen in der Behandlung der Schizophrenie erklärt sich vor allem hieraus. Die Folgen von Mal-Compliance für den Erkrankungsverlauf sind gravierend. Ausgehend von Daten zu Prävalenz von Mal-Compliance werden wichtige Befunde referiert zu Determinanten und theoretischen Vorstellungen, die Ausgangspunkt für nachhaltigere therapeutische Interventionen werden können. Die wichtigen Interventionstypen werden in ihrer differenziellen Wirksamkeit dargestellt.


Focussing Compliance Enhancement in Schizophrenia

Deficits in adherence to treatment plan in schizophrenia in spite of availability of atypicals with lower rate of side effects persist as a severe risk for long term course of schizophrenia. Maladherence is the main reason for the gap between effectivity of treatment and poor outcome in schizophrenia. Data concerning prevalence of malcompliance and its’ preceding variables as well as theoretical frameworks are discussed. Main intervention strategies and their efficacy are reported.

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