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Themenschwerpunkt

Pharmakotherapie der bipolaren Störungen und der Manie

Published Online:February 28, 2015https://doi.org/10.1024/1661-4747/a000204

Abstract

Die pharmakologische Therapie der bipolaren Störung stellt im Rahmen eines bio-psychosozialen Krankheitsmodells eine Herausforderung dar. Die klinische Symptomatik kann sich in akuter Manie, Hypomanie, bipolarer Depression und Mischzuständen manifestieren. Besondere Beachtung verdient die Adhärenz, welche sich ebenso vielschichtig äussern kann, und bei welcher Komorbiditäten eine wichtige Rolle spielen. In diesem Artikel wird eine Zusammenstellung wichtiger nationaler und internationaler Therapierichtlinien zu bipolaren Störungen diskutiert und wesentliche Resultate synoptisch präsentiert mit dem Ziel, der interessierten Leserschaft einen raschen Überblick über aktuelle pharmakologische Therapiemodalitäten zu erlauben.


Pharmacotherapy of bipolar disorder and acute mania

Pharmacotherapy of bipolar disorder is challenging. Symptomatology over the course of the disease can manifest in different ways: as acute mania, hypomania, bipolar depression and mixed states. Adherence of patients with bipolar disorder is complex, and psychiatric comorbidities play an important role. Relevant national and international guidelines are discussed in this review, and state-of-the-art recommendations are presented. A major purpose is to provide the reader with an appropriate overview of current treatment modalities.

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