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Short Review

Refining Evidence-Based Treatments for Late-Life Depression

Published Online:June 03, 2015https://doi.org/10.1024/1662-9647/a000127

Abstract

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.

References

  • Abraham, C., & Michie, S. (2008). A taxonomy of behavior change techniques used in interventions. Health Psychology, 27, 379–387. doi 10.1037/0278-6133.27.3.379 First citation in articleCrossref, Google Scholar

  • Akincigil, A., Olfson, M., Walkup, J. T., Siegel, M. J., Kalay, E., Amin, S., ... Crystal, S. (2011). Diagnosis and treatment of depression in older community-dwelling adults: 1992–2005. Journal of the American Geriatrics Society, 59, 1042–1051. doi 10.1111/j.1532-5415.2011.03447.x First citation in articleCrossref, Google Scholar

  • Alexopoulos, G. S., & Arean, P. (2014). A model for streamlining psychotherapy in the RDoc era: The example of “Engage.” Molecular Psychiatry, 19(1), 14–19. doi 10.1038/mp.2013.150 First citation in articleCrossref, Google Scholar

  • Alexopoulos, G. S., Kiosses, D. N., Klimstra, S., Kalayam, B., & Bruce, M. L. (2002). Clinical presentation of the “depression-executive dysfunction syndrome” of late life. American Journal of Geriatric Psychiatry, 10(1), 98–106. First citation in articleGoogle Scholar

  • Alexopoulos, G. S., Kiosses, D. N., Murphy, C., & Heo, M. (2004). Executive dysfunction, heart disease burden, and remission of geriatric depression. Neuropsychopharmacology, 29, 2278–2284. doi 10.1038/sj.npp.1300557 First citation in articleCrossref, Google Scholar

  • Alexopoulos, G. S., Raue, P. J., Kiosses, D. N., Mackin, R. S., Kanellopoulos, D., McCulloch, C., & Arean, P. A. (2011). Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: Effect on disability. Archives of General Psychiatry, 68(1), 33–41. doi 10.1001/archgenpsychiatry.2010.177 First citation in articleCrossref, Google Scholar

  • Arean, P. A. (2012). Personalizing behavioral interventions: The case of late-life depression. Neuropsychiatry (London), 2, 135–145. doi 10.2217/npy.12.15 First citation in articleCrossref, Google Scholar

  • Arean, P. A., Alvidrez, J., Barrera, A., Robinson, G. S., & Hicks, S. (2002). Would older medical patients use psychological services?. The Gerontologist, 42, 392–398. First citation in articleGoogle Scholar

  • Arean, P., Hegel, M., Vannoy, S., Fan, M. Y., & Unuzter, J. (2008). Effectiveness of problem-solving therapy for older, primary-care patients with depression: Results from the IMPACT project. The Gerontologist, 48, 311–323. First citation in articleCrossref, Google Scholar

  • Arean, P. A., Perri, M. G., Nezu, A. M., Schein, R. L., Christopher, F., & Joseph, T. X. (1993). Comparative effectiveness of social problem-solving therapy and reminiscence therapy as treatments for depression in older adults. Journal of Consulting and Clinical Psychology, 61, 1003–1010. First citation in articleCrossref, Google Scholar

  • Arean, P. A., Raue, P., Mackin, R. S., Kanellopoulos, D., McCulloch, C., & Alexopoulos, G. S. (2010). Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. American Journal of Psychiatry, 167, 1391–1398. doi 10.1176/appi.ajp.2010.09091327 First citation in articleCrossref, Google Scholar

  • Baldwin, R., Jeffries, S., Jackson, A., Sutcliffe, C., Thacker, N., Scott, M., & Burns, A. (2004). Treatment response in late-onset depression: Relationship to neuropsychological, neuroradiological and vascular risk factors. Psychological Medicine, 34, 125–136. First citation in articleCrossref, Google Scholar

  • Barg, F. K., Mavandadi, S., Givens, J. L., Knott, K., Zubritsky, C., & Oslin, D. W. (2010). When late-life depression improves: What do older patients say about their treatment?. American Journal of Geriatric Psychiatry, 18, 596–605. First citation in articleCrossref, Google Scholar

  • Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. The American Journal of Psychiatry, 165, 969–977. doi 10.1176/appi.ajp.2008.08050721 First citation in articleCrossref, Google Scholar

  • Beidas, R. S., Aarons, G., Barg, F., Evans, A., Hadley, T., Hoagwood, K., ... Mandell, D. S. (2013). Policy to implementation: Evidence-based practice in community mental health – study protocol. Implementation Science, 8, 38. doi 10.1186/1748-5908-8-38 First citation in articleCrossref, Google Scholar

  • Bella, R., Pennisi, G., Cantone, M., Palermo, F., Pennisi, M., Lanza, G., ... Paolucci, S. (2010). Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. Gerontology, 56, 298–302. doi 10.1159/000272003 First citation in articleCrossref, Google Scholar

  • Blendy, J. A. (2006). The role of CREB in depression and antidepressant treatment. Biological Psychiatry, 59, 1144–1150. doi 10.1016/j.biopsych.2005.11.003 First citation in articleCrossref, Google Scholar

  • Bogner, H. R., Bruce, M. L., Reynolds, C. F., 3rd, Mulsant, B. H., Cary, M. S., Morales, K., ... Group, P. (2007). The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary-care intervention trial: The PROSPECT study. International Journal of Geriatric Psychiatry, 22, 922–929. doi 10.1002/gps.1767 First citation in articleCrossref, Google Scholar

  • Chambers, D. A. (2008). Advancing the science of implementation: A workshop summary. Administration and Policy in Mental Health, 35(1–2), 3–10. doi 10.1007/s10488-007-0146-7 First citation in articleCrossref, Google Scholar

  • Coffey, C. E., Figiel, G. S., Djang, W. T., Saunders, W. B., & Weiner, R. D. (1989). White matter hyperintensity on magnetic resonance imaging: Clinical and neuroanatomic correlates in the depressed elderly. The Journal of Neuropsychiatry and Clinical Neuroscience, 1, 135–144. First citation in articleCrossref, Google Scholar

  • Conner, K. O., Copeland, V. C., Grote, N. K., Koeske, G., Rosen, D., Reynolds, C. F. 3rd, & Brown, C. (2010). Mental health treatment seeking among older adults with depression: The impact of stigma and race. The American Journal of Geriatric Psychiatry, 18, 531–543. doi 10.1097/JGP.0b013e3181cc0366 First citation in articleCrossref, Google Scholar

  • Cuijpers, P., van Straten, A., & Smit, F. (2006). Psychological treatment of late-life depression: A meta-analysis of randomized controlled trials. International Journal of Geriatric Psychiatry, 21, 1139–1149. doi 10.1002/gps.1620 First citation in articleCrossref, Google Scholar

  • Cuthbert, B. N. (2014). Research domain criteria: Toward future psychiatric nosology. Asian Journal of Psychiatry, 7(1), 4–5. doi 10.1016/j.ajp.2013.12.007 First citation in articleCrossref, Google Scholar

  • Cuthbert, B. N., & Insel, T. R. (2010). Toward new approaches to psychotic disorders: The NIMH Research Domain Criteria project. Schizophrenia Bulletin, 36, 1061–1062. doi 10.1093/ schbul/sbq108 First citation in articleCrossref, Google Scholar

  • Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Arolt, V., Heindel, W., ... Suslow, T. (2007). Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: A 3 T fMRI study. Journal of Psychiatry and Neuroscience, 32, 423–429. First citation in articleGoogle Scholar

  • Dimidjian, S., Barrera, M., Jr., Martell, C., Munoz, R. F., & Lewinsohn, P. M. (2011). The origins and current status of behavioral activation treatments for depression. Annual Review of Clinical Psychology, 7, 1–38. doi 10.1146/annurev-clinpsy-032210-104535 First citation in articleCrossref, Google Scholar

  • Dombrovski, A. Y., Siegle, G. J., Szanto, K., Clark, L., Reynolds, C. F., & Aizenstein, H. (2012). The temptation of suicide: Striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychological Medicine, 42, 1203–1215. doi 10.1017/S0033291711002133 First citation in articleCrossref, Google Scholar

  • Drevets, W. C. (2004). Neuroplasticity in mood disorders. Dialogues in Clinical Neuroscience, 6, 199–216. First citation in articleGoogle Scholar

  • Driscoll, H. C., Karp, J. F., Dew, M. A., & Reynolds, C. F. 3rd. (2007). Getting better, getting well: Understanding and managing partial and nonresponse to pharmacological treatment of non-psychotic major depression in old age. Drugs & Aging, 24, 801–814. First citation in articleCrossref, Google Scholar

  • Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G. L., & Overstreet-Wadiche, L. S. (2008). Adult neurogenesis, mental health, and mental illness: Hope or hype?. The Journal of Neuroscience, 28, 11785–11791. doi 10.1523/JNEUROSCI.3798-08.2008 First citation in articleCrossref, Google Scholar

  • Eppinger, B., Hammerer, D., & Li, S. C. (2011). Neuromodulation of reward-based learning and decision making in human aging. Annals of the New York Academy of Sciences, 1235, 1–17. doi 10.1111/j.1749-6632.2011.06230.x First citation in articleCrossref, Google Scholar

  • Fiske, A., Wetherell, J. L., & Gatz, M. (2009). Depression in older adults. Annual Review of Clinical Psychology, 5, 363–389. doi 10.1146/annurev.clinpsy.032408.153621 First citation in articleCrossref, Google Scholar

  • Gallo, J. J., Bogner, H. R., Morales, K. H., Post, E. P., Ten Have, T., & Bruce, M. L. (2005). Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. The American Journal of Geriatric Psychiatry, 13, 748–755. doi 10.1176/appi.ajgp.13.9.748 First citation in articleCrossref, Google Scholar

  • Gallo, J. J., Morales, K. H., Bogner, H. R., Raue, P. J., Zee, J., Bruce, M. L., & Reynolds, C. F. 3rd. (2013). Long term effect of depression care management on mortality in older adults: Follow-up of cluster randomized clinical trial in primary care. The British Medical Journal, 346, f2570. doi 10.1136/bmj.f2570 First citation in articleGoogle Scholar

  • Gehart, D. (2011). The core competencies and MFT education: Practical aspects of transitioning to a learning-centered, outcome-based pedagogy. Journal of Marital and Family Therapy, 37, 344–354. doi 10.1111/j.1752-0606.2010.00205.x First citation in articleCrossref, Google Scholar

  • Gentili, R., Han, C. E., Schweighofer, N., & Papaxanthis, C. (2010). Motor learning without doing: Trial-by-trial improvement in motor performance during mental training. Journal of Neurophysiology, 104, 774–783. doi 10.1152/jn.00257.2010 First citation in articleCrossref, Google Scholar

  • Goldman, H. H., & Azrin, S. T. (2003). Public policy and evidence-based practice. The Psychiatric Clinics of North America, 26, 899–917. First citation in articleCrossref, Google Scholar

  • Gordon, E., Barnett, K. J., Cooper, N. J., Tran, N., & Williams, L. M. (2008). An “integrative neuroscience” platform: Application to profiles of negativity and positivity bias. Journal of Integrative Neuroscience, 7, 345–366. First citation in articleCrossref, Google Scholar

  • Goto, Y., Yang, C. R., & Otani, S. (2010). Functional and dysfunctional synaptic plasticity in prefrontal cortex: Roles in psychiatric disorders. Biol Psychiatry, 67, 199–207. doi 10.1016/j.biopsych.2009.08.026 First citation in articleCrossref, Google Scholar

  • Gum, A. M., Iser, L., & Petkus, A. (2010). Behavioral health service utilization and preferences of older adults receiving home-based aging services. The American Journal of Geriatric Psychiatry, 18, 491–501. doi 10.1097/JGP.0b013e3181c29495 First citation in articleCrossref, Google Scholar

  • Gunning, F. M., Cheng, J., Murphy, C. F., Kanellopoulos, D., Acuna, J., Hoptman, M. J., ... Alexopoulos, G. S. (2009). Anterior cingulate cortical volumes and treatment remission of geriatric depression. International Journal of Geriatric Psychiatry, 24, 829–836. doi 10.1002/gps.2290 First citation in articleCrossref, Google Scholar

  • Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., ... Lu, X. Y. (2012). Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Translational Psychiatry, 2, e83. doi 10.1038/tp.2012.9 First citation in articleGoogle Scholar

  • Hyman, S. E. (2007). Can neuroscience be integrated into the DSM-V?. Nature Reviews Neuroscience, 8, 725–732. doi 10.1038/nrn2218 First citation in articleCrossref, Google Scholar

  • Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., ... Wang, P. (2010). Research domain criteria (RDoc): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry, 167, 748–751. doi 10.1176/appi.ajp.2010.09091379 First citation in articleCrossref, Google Scholar

  • Kalayam, B., & Alexopoulos, G. S. (1999). Prefrontal dysfunction and treatment response in geriatric depression. Archives of General Psychiatry, 56, 713–718. First citation in articleCrossref, Google Scholar

  • Kalayam, B., Alexopoulos, G. S., Musiek, F. E., Kakuma, T., Toro, A., Silbersweig, D., & Young, R. C. (1997). Brainstem evoked response abnormalities in late-life depression with vascular disease. American Journal of Psychiatry, 154, 970–975. First citation in articleCrossref, Google Scholar

  • Kelly, K. G., & Zisselman, M. (2000). Update on electroconvulsive therapy (ECT) in older adults. Journal of the American Geriatrics Society, 48, 560–566. First citation in articleCrossref, Google Scholar

  • Kerwin, M., Nunes, F., & Silva, P. A. (2012). Dance! Don’t fall – Preventing falls and promoting exercise at home. Studies in Health Technology and Informatics, 177, 254–259. First citation in articleGoogle Scholar

  • Kessler, R. C., Birnbaum, H., Bromet, E., Hwang, I., Sampson, N., & Shahly, V. (2010). Age differences in major depression: Results from the National Comorbidity Survey Replication (NCS-R). Psychological Medicine, 40, 225–237. doi 10.1017/ S0033291709990213 First citation in articleCrossref, Google Scholar

  • Kiosses, D. N., Leon, A. C., & Arean, P. A. (2011). Psychosocial interventions for late-life major depression: Evidence-based treatments, predictors of treatment outcomes, and moderators of treatment effects. The Psychiatric Clinics of North America, 34, 377–401, viii. doi 10.1016/j.psc.2011.03.001 First citation in articleCrossref, Google Scholar

  • Kiosses, D. N., Teri, L., Velligan, D. I., & Alexopoulos, G. S. (2011). A home-delivered intervention for depressed, cognitively impaired, disabled elders. International Journal of Geriatric Psychiatry, 26, 256–262. doi 10.1002/gps.2521 First citation in articleCrossref, Google Scholar

  • Kolla, N. J., Links, P. S., McMain, S., Streiner, D. L., Cardish, R., & Cook, M. (2009). Demonstrating adherence to guidelines for the treatment of patients with borderline personality disorder. Canadian Journal of Psychiatry. Revue canadienne de psychiatrie, 54, 181–189. First citation in articleCrossref, Google Scholar

  • Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010). Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proceedings of the National Academy of Sciences of the United States of America, 107, 2669–2674. doi 10.1073/pnas.0910658107 First citation in articleGoogle Scholar

  • Kraus, C. A., Kunik, M. E., & Stanley, M. A. (2007). Use of cognitive behavioral therapy in late-life psychiatric disorders. Geriatrics, 62(6), 21–26. First citation in articleGoogle Scholar

  • Kunisato, Y., Okamoto, Y., Ueda, K., Onoda, K., Okada, G., Yoshimura, S., ... Yamawaki, S. (2012). Effects of depression on reward-based decision making and variability of action in probabilistic learning. Journal of Behavior Therapy and Experimental Psychiatry, 43, 1088–1094. doi 10.1016/j.jbtep.2012.05.007 First citation in articleCrossref, Google Scholar

  • Kuo, W. H., & Gallo, J. J. (2005). Completed suicide after a suicide attempt. American Journal of Psychiatry, 162, 633. doi 10.1176/appi.ajp.162.3.633 First citation in articleCrossref, Google Scholar

  • Lorencatto, F., West, R., Bruguera, C., & Michie, S. (2014). A method for assessing fidelity of delivery of telephone behavioral support for smoking cessation. Journal of Consulting and Clinical Psychology, 82, 482–491. doi 10.1037/a0035149 First citation in articleCrossref, Google Scholar

  • Lorencatto, F., West, R., Christopherson, C., & Michie, S. (2013). Assessing fidelity of delivery of smoking cessation behavioural support in practice. Implementation Science, 8, 40. doi 10.1186/1748-5908-8-40. First citation in articleCrossref, Google Scholar

  • McHugh, R. K., & Barlow, D. H. (2010). The dissemination and implementation of evidence-based psychological treatments. A review of current efforts. American Psychologist, 65, 73–84. doi 10.1037/a0018121 First citation in articleCrossref, Google Scholar

  • McHugh, R. K., Murray, H. W., & Barlow, D. H. (2009). Balancing fidelity and adaptation in the dissemination of empirically supported treatments: The promise of transdiagnostic interventions. Behaviour Research Therapy, 47, 946–953. doi 10.1016/ j.brat.2009.07.005 First citation in articleCrossref, Google Scholar

  • Mellman, L. A., & Beresin, E. (2003). Psychotherapy competencies: Development and implementation. Academic Psychiatry, 27, 149–153. doi 10.1176/appi.ap.27.3.149 First citation in articleCrossref, Google Scholar

  • Michie, S., & Abraham, C. (2008). Advancing the science of behaviour change: A plea for scientific reporting. Addiction, 103, 1409–1410. doi 10.1111/j.1360-0443.2008.02291.x First citation in articleCrossref, Google Scholar

  • Michie, S., Ashford, S., Sniehotta, F. F., Dombrowski, S. U., Bishop, A., & French, D. P. (2011). A refined taxonomy of behaviour change techniques to help people change their physical activity and healthy eating behaviours: The CALO-RE taxonomy. Psychological Health, 26, 1479–1498. doi 10.1080/ 08870446.2010.540664 First citation in articleCrossref, Google Scholar

  • Michie, S., Hyder, N., Walia, A., & West, R. (2011). Development of a taxonomy of behaviour change techniques used in individual behavioural support for smoking cessation. Addictive Behaviors, 36, 315–319. doi 10.1016/j.addbeh.2010.11.016 First citation in articleCrossref, Google Scholar

  • Michie, S., Whittington, C., Hamoudi, Z., Zarnani, F., Tober, G., & West, R. (2012). Identification of behaviour change techniques to reduce excessive alcohol consumption. Addiction, 107, 1431–1440. doi 10.1111/j.1360-0443.2012.03845.x First citation in articleCrossref, Google Scholar

  • Mohlman, J. (2012). A community based survey of older adults’ preferences for treatment of anxiety. Psychology and Aging, 27, 1182–1190. doi 10.1037/a0023126 First citation in articleCrossref, Google Scholar

  • Monin, J. K., Schulz, R., Martire, L. M., Jennings, J. R., Lingler, J. H., & Greenberg, M. S. (2010). Spouses’ cardiovascular reactivity to their partners’ suffering. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 65B, 195–201. doi 10.1093/geronb/gbp133 First citation in articleCrossref, Google Scholar

  • Monk, C. S., Klein, R. G., Telzer, E. H., Schroth, E. A., Mannuzza, S., Moulton, J. L., 3rd, ... Ernst, M. (2008). Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. American Journal of Psychiatry, 165, 90–98. doi 10.1176/appi.ajp.2007.06111917 First citation in articleCrossref, Google Scholar

  • Morris, S. E., Rumsey, J. M., & Cuthbert, B. N. (2014). Rethinking mental disorders: The role of learning and brain plasticity. Restorative Neurology and Neuroscience, 32(1), 5–23. doi 10.3233/RNN-139015 First citation in articleGoogle Scholar

  • Munafo, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852–857. doi 10.1016/j.biopsych.2007.08.016 First citation in articleCrossref, Google Scholar

  • Nelson, J. C., Delucchi, K., & Schneider, L. S. (2008). Efficacy of second generation antidepressants in late-life depression: A meta-analysis of the evidence. The American Journal of Geriatric Psychiatry, 16, 558–567. doi 10.1097/JGP.0b013e3181693288 First citation in articleCrossref, Google Scholar

  • Nelson, J. C., Thase, M. E., & Khan, A. (2008). Are antidepressants effective? What’s a clinician to think?. The Journal of Clinical Psychiatry, 69, 1014–1015. First citation in articleCrossref, Google Scholar

  • Niciu, M. J., Mathews, D. C., Nugent, A. C., Ionescu, D. F., Furey, M. L., Richards, E. M., ... Zarate, C. A., Jr. (2014). Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants. Depression and Anxiety, 31, 297–307. doi 10.1002/da.22224 First citation in articleCrossref, Google Scholar

  • Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008). A neural model of voluntary and automatic emotion regulation: Implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry, 13, 829, 833–857. doi 10.1038/mp.2008.65 First citation in articleGoogle Scholar

  • Pittenger, C., & Duman, R. S. (2008). Stress, depression, and neuroplasticity: A convergence of mechanisms. Neuropsychopharmacology, 33(1), 88–109. doi 10.1038/sj.npp.1301574 First citation in articleCrossref, Google Scholar

  • Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., ... Fava, M. (2009). Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. American Journal of Psychiatry, 166, 702–710. doi 10.1176/appi.ajp.2008.08081201 First citation in articleCrossref, Google Scholar

  • Post, R. M. (2007). Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena. Neuroscience & Biobehavioral Reviews, 31, 858–873. doi 10.1016/j.neubiorev.2007.04.003 First citation in articleCrossref, Google Scholar

  • Potter, G. G., Kittinger, J. D., Wagner, H. R., Steffens, D. C., & Krishnan, K. R. (2004). Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology, 29, 2266–2271. doi 10.1038/sj.npp.1300551 First citation in articleCrossref, Google Scholar

  • Raue, P. J., Schulberg, H. C., Heo, M., Klimstra, S., & Bruce, M. L. (2009). Patients’ depression treatment preferences and initiation, adherence, and outcome: A randomized primary-care study. Psychiatric Services, 60, 337–343. doi 10.1176/ appi.ps.60.3.337 First citation in articleCrossref, Google Scholar

  • Robinson, O. J., Cools, R., Carlisi, C. O., Sahakian, B. J., & Drevets, W. C. (2012). Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder. American Journal of Psychiatry, 169, 152–159. First citation in articleCrossref, Google Scholar

  • Roth, A. D., Pilling, S., & Turner, J. (2010). Therapist training and supervision in clinical trials: Implications for clinical practice. Behavioural and Cognitive Psychotherapy, 38, 291–302. doi 10.1017/S1352465810000068 First citation in articleCrossref, Google Scholar

  • Russo, S. J., & Nestler, E. J. (2013). The brain reward circuitry in mood disorders. Nature Reviews Neuroscience, 14, 609–625. doi 10.1038/nrn3381 First citation in articleCrossref, Google Scholar

  • Sburlati, E. S., Schniering, C. A., Lyneham, H. J., & Rapee, R. M. (2011). A model of therapist competencies for the empirically supported cognitive behavioral treatment of child and adolescent anxiety and depressive disorders. Clinical Child and Family Psychology Review, 14(1), 89–109. doi 10.1007/s10567-011-0083-6 First citation in articleCrossref, Google Scholar

  • Schloesser, R. J., Huang, J., Klein, P. S., & Manji, H. K. (2008). Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology, 33(1), 110–133. doi 10.1038/sj.npp.1301575 First citation in articleCrossref, Google Scholar

  • Sheline, Y. I., Pieper, C. F., Barch, D. M., Welsh-Bohmer, K., McKinstry, R. C., MacFall, J. R., ... Doraiswamy, P. M. (2010). Support for the vascular depression hypothesis in late-life depression: Results of a 2-site, prospective, antidepressant treatment trial. Archives of General Psychiatry, 67, 277–285. doi 10.1001/archgenpsychiatry.2009.204 First citation in articleGoogle Scholar

  • Sinclair, J. M., Burton, A., Ashcroft, R., & Priebe, S. (2011). Clinician and service user perceptions of implementing contingency management: A focus group study. Drug and Alcohol Dependence, 119(1–2), 56–63. doi 10.1016/j.drugalcdep.2011.05.016 First citation in articleCrossref, Google Scholar

  • Sneed, J. R., Culang, M. E., Keilp, J. G., Rutherford, B. R., Devanand, D. P., & Roose, S. P. (2010). Antidepressant medication and executive dysfunction: A deleterious interaction in late-life depression. American Journal of Geriatric Psychiatry, 18, 128–135. doi 10.1097/JGP.0b013e3181c796d2 First citation in articleCrossref, Google Scholar

  • Sneed, J. R., & Culang-Reinlieb, M. E. (2011). The vascular depression hypothesis: An update. American Journal of Geriatric Psychiatry, 19, 99–103. First citation in articleGoogle Scholar

  • Sneed, J. R., Culang-Reinlieb, M. E., Brickman, A. M., Gunning-Dixon, F. M., Johnert, L., Garcon, E., & Roose, S. P. (2011). MRI signal hyperintensities and failure to remit following antidepressant treatment. Journal of Affective Disorders, 135, 315–320. doi 10.1016/j.jad.2011.06.052 First citation in articleCrossref, Google Scholar

  • Sneed, J. R., Keilp, J. G., Brickman, A. M., & Roose, S. P. (2008). The specificity of neuropsychological impairment in predicting antidepressant nonresponse in the very old depressed. International Journal of Geriatric Psychiatry, 23, 319–323. doi 10.1002/gps.1889 First citation in articleCrossref, Google Scholar

  • Sneed, J. R., Roose, S. P., Keilp, J. G., Krishnan, K. R., Alexopoulos, G. S., & Sackeim, H. A. (2007). Response inhibition predicts poor antidepressant treatment response in very old depressed patients. American Journal of Geriatric Psychiatry, 15, 553–563. doi 10.1097/JGP.0b013e3180302513 First citation in articleCrossref, Google Scholar

  • Spruill, J., Rozensky, R. H., Stigall, T. T., Vasquez, M., Bingham, R. P., & De Vaney Olvey, C. (2004). Becoming a competent clinician: Basic competencies in intervention. Journal of Clinical Psychology, 60, 741–754. doi 10.1002/jclp.20011 First citation in articleCrossref, Google Scholar

  • Stahl, S. M. (2013). The last Diagnostic and Statistical Manual (DSM): Replacing our symptom-based diagnoses with a brain circuit-based classification of mental illnesses. CNS Spectrums, 18, 65–68. First citation in articleCrossref, Google Scholar

  • Stahmer, A. C., & Aarons, G. (2009). Attitudes toward adoption of evidence-based practices: A comparison of autism early intervention providers and children’s mental-health providers. Psychological Services, 6, 223–234. doi 10.1037/a0010738 First citation in articleCrossref, Google Scholar

  • Sun, H., Kennedy, P. J., & Nestler, E. J. (2013). Epigenetics of the depressed brain: Role of histone acetylation and methylation. Neuropsychopharmacology, 38(1), 124–137. doi 10.1038/ npp.2012.73 First citation in articleCrossref, Google Scholar

  • Takeuchi, T., Duszkiewicz, A. J., & Morris, R. G. (2014). The synaptic plasticity and memory hypothesis: Encoding, storage and persistence. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1633), 20130288. doi 10.1098/rstb.2013.0288 First citation in articleGoogle Scholar

  • Takahashi, T., Oono, H., Inoue, T., Boku, S., Kako, Y., Kitaichi, Y., ... Radford, M. H. (2008). Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects: An analysis based on Tsallis’ statistics. Neuroendocrinology Letters, 29, 351–358. First citation in articleGoogle Scholar

  • Thornicroft, G. (2012). Evidence-based mental-health care and implementation science in low- and middle-income countries. Epidemiology and Psychiatric Sciences, 21, 241–244. doi 10.1017/S2045796012000261 First citation in articleCrossref, Google Scholar

  • Tournier, M., Moride, Y., Crott, R., du Fort, G. G., & Ducruet, T. (2009). Economic impact of nonpersistence to antidepressant therapy in the Quebec community-dwelling elderly population. Journal of Affective Disorders, 115, 160–166. doi 10.1016/ j.jad.2008.07.004 First citation in articleCrossref, Google Scholar

  • Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H. C., Finkelstein, J., ... Deisseroth, K. (2013). Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature, 493(7433), 537–541. doi 10.1038/nature11740 First citation in articleCrossref, Google Scholar

  • Unutzer, J., Bruce, M. L., & Workgroup, N. A. D. (2002). The elderly. Mental Health Services Research, 4, 245–247. First citation in articleCrossref, Google Scholar

  • Unutzer, J., Katon, W., Callahan, C. M., Williams, J. W. Jr., Hunkeler, E., Harpole, L., ... Langston, C. (2002). Collaborative care management of late-life depression in the primary-care setting: A randomized controlled trial. The Journal of the American Medical Association, 288, 2836–2845. doi joc21093 [pii] First citation in articleCrossref, Google Scholar

  • Vialou, V., Robison, A. J., Laplant, Q. C., Covington, H. E., 3rd, Dietz, D. M., Ohnishi, Y. N., ... Nestler, E. J. (2010). DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature Neuroscience, 13, 745–752. doi 10.1038/nn.2551 First citation in articleCrossref, Google Scholar

  • Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009). The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques. Neuroimage, 46, 327–337. doi 10.1016/j.neuroimage.2009.01.058 First citation in articleCrossref, Google Scholar

  • Warner-Schmidt, J. L., Schmidt, E. F., Marshall, J. J., Rubin, A. J., Arango-Lievano, M., Kaplitt, M. G., ... Greengard, P. (2012). Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America, 109, 11360–11365. doi 10.1073/pnas.1209293109 First citation in articleGoogle Scholar

  • Willard, S. L., Friedman, D. P., Henkel, C. K., & Shively, C. A. (2009). Anterior hippocampal volume is reduced in behaviorally depressed female cynomolgus macaques. Psychoneuroendocrinology, 34, 1469–1475. doi 10.1016/j.psyneuen.2009.04.022 First citation in articleCrossref, Google Scholar

  • Williams, L. M., Gatt, J. M., Grieve, S. M., Dobson-Stone, C., Paul, R. H., Gordon, E., & Schofield, P. R. (2010). COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. Neuroimage, 53, 918–925. doi 10.1016/j.neuroimage.2010.01.084 First citation in articleCrossref, Google Scholar

  • Williams, L. M., Gatt, J. M., Schofield, P. R., Olivieri, G., Peduto, A., & Gordon, E. (2009). ’Negativity bias’ in risk for depression and anxiety: Brain-body fear circuitry correlates, 5-HTT-LPR and early life stress. Neuroimage, 47, 804–814. doi 10.1016/j.neuroimage.2009.05.009 First citation in articleCrossref, Google Scholar

  • Wilson, K. C., Mottram, P. G., & Vassilas, C. A. (2008). Psychotherapeutic treatments for older depressed people. Cochrane Database of Systematic Reviews, CD004853. doi 10.1002/ 14651858.CD004853.pub2 First citation in articleGoogle Scholar

  • Zivin, K., & Kales, H. C. (2008). Adherence to depression treatment in older adults: A narrative review. Drugs and Aging, 25, 559–571. First citation in articleCrossref, Google Scholar