What Does Brain Imaging Tell Us About the Predisposition to Suicidal Behavior

References

• Arango, V., Ernsberger, P., Marzuk, P.M., Chen, J.-S., Tierney, H., Stanley, M., Reis, D.J., Mann, J.J. (1990). Autoradiographic demonstration of increased serotonin 5-HT₂ and Beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry, 47, 1038–1047 First citation in articleCrossref Medline, Google Scholar

• Arango, V., Underwood, M.D., Boldrini, M., Tamir, H., Kassir, S.A., Hsiung, S., Chen, J.J.X., Mann, J.J. (2001). Serotonin 1A receptors, serotonin transporter binding, and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology, 25, 892–903 First citation in articleCrossref Medline, Google Scholar

• Audenaert, K., Van Laere, K., Dumont, F., Slegers, G., Mertens, J., van Heeringen, C., Dierckx, R.A. (2001). Decreased frontal serotonin 5-HT 2a receptor binding index in deliberate self-harm patients. European Journal of Nuclear Medicine, 28, 175–182 First citation in articleCrossref Medline, Google Scholar

• Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389 First citation in articleCrossref Medline, Google Scholar

• Goethals, I., Audenaert, K., Jacobs, F., Van den, E.F., Bernagie, K., Kolindou, A., Vervaet, M., Dierckx, R., van Heeringen, C. (2005). Brain perfusion SPECT in impulsivity-related personality disorders. Behavioral Brain Research, 157, 187–192 First citation in articleCrossref Medline, Google Scholar

• Hariri, A.R., Drabant, E.M., Munoz, K.E., Kolachana, B.S., Mattay, V.S., Egan, M.F., Weinberger, D.R. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152 First citation in articleCrossref Medline, Google Scholar

• Mann, J.J. (1995). Violence and aggression. In F.E. Bloom & D.J. Kupfer (Eds.), Psychopharmacology: The fourth generation of progress (pp. 1919-1928). New York: Raven First citation in articleGoogle Scholar

• Mann, J.J. (2002). A current perspective of suicide and attempted suicide. Annals of Internal Medicine, 136, 302–311 First citation in articleCrossref Medline, Google Scholar

• Mann, J.J., Huang, Y.Y., Underwood, M.D., Kassir, S.A., Oppenheim, S., Kelly, T.M., Dwork, A.J., Arango, V. (2000). A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of General Psychiatry, 57, 729–738 First citation in articleCrossref Medline, Google Scholar

• Oquendo, M.A., Placidi, G.P., Malone, K.M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L.S., Cooper, T.B., Parsey, R.V., Van Heertum, R.L., Mann, J.J. (2003). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of General Psychiatry, 60, 14–22 First citation in articleCrossref Medline, Google Scholar

• Parsey, R.V., Oquendo, M.A., Simpson, N.R., Ogden, R.T., Van Heertum, R., Arango, V., Mann, J.J. (2002). Effects of sex, age, and aggressive traits in man on brain serotonin 5- HT(1A) receptor binding potential measured by PET using [C-11]WAY- 100635. Brain Research, 954, 173–182 First citation in articleCrossref Medline, Google Scholar

• Raine, A., Meloy, J.R., Bihrle, S., Stoddard, J., LaCasse, L., Buchsbaum, M.S.Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers. Behavioral Science and the Law, 16, 319–332 First citation in articleCrossref Medline, Google Scholar

• Siever, L.J., Buchsbaum, M.S., New, A.S., Spiegel-Cohen, J., Wei, T., Hazlett, E.A., Sevin, E., Nunn, M., Mitropoulou, V. (1999). d,1-fenfluramine response in impulsive personality disorder assessed with [¹⁸F]fluorodeoxyglucose Positron Emission Tomography. Neuropsychopharmacology, 20, 413–423 First citation in articleCrossref Medline, Google Scholar

• Smith, K.A., Morris, J.S., Friston, K.J., Cowen, P.J., Dolan, R.J. (1999). Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion. British Journal of Psychiatry, 174, 525–529 First citation in articleCrossref Medline, Google Scholar

• Soloff, P.H., Meltzer, C.C., Becker, C., Greer, P.J., Kelly, T.M., Constantine, D. (2003). Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Research, 123, 153–163 First citation in articleCrossref Medline, Google Scholar

• Soloff, P.H., Meltzer, C.C., Greer, P.J., Constantine, D., Kelly, T.M. (2000). A fenfluramine-activated FDG-PET study of borderline personality disorder. Biological Psychiatry, 47, 540–547 First citation in articleCrossref Medline, Google Scholar

• Tiihonen, J., Kuikka, J.T., Bergström, K.A., Karhu, J., Lehtonen, J., Hallikainen, T., Yang, J., Hakola, P. (1997). Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour. European Journal of Nuclear Medicine, 24, 1253–1260 First citation in articleCrossref Medline, Google Scholar

• van Heeringen, C., Audenaert, K., Van Laere, K., Dumont, F., Slegers, G., Mertens, J., Dierckx, R.A. (2003). Prefrontal 5-HT2a receptor binding index, hopelessness, and personality characteristics in attempted suicide. Journal of Affective Disorders, 74, 149–158 First citation in articleCrossref Medline, Google Scholar

• Zalsman, G., Huang, Y., Oquendo, M.A., Burke, A., Hu, X., Brent, D.A., Goldman, D., Mann, J.J. (in press). A triallelic serotonin transporter gene promoter polymorphism (5-HTTLPR), stressful life events and severity of depression. American Journal of Psychiatry, First citation in articleGoogle Scholar