N400 Peculiarities During Intentional Inferences Production in Subjects With Schizotypal Traits
Preserved Predictions of Intentions but Altered Context Integration
Abstract
Abstract. A deficit in context processing may underlie theory of mind (ToM) difficulties in schizophrenia, although few studies to date have explored the impact of contextual processing on ToM performances within the same task. We used electroencephalography to investigate the production of intentional inferences from highly versus weakly structured sentences in healthy participants with schizotypal traits. Thirty-four participants were divided into two groups according to their scores on the Schizotypal Personality Questionnaire (SPQ). The participants listened to stories that required a degree of understanding in order to produce an inference about the main character’s intention. Each story was followed by a target word that could either be highly predictable (HP), weakly predictable (WP), or incompatible with the context. The results indicate that the N400 component for WP targets was stronger in the high-SPQ group. This increase correlated with the negative dimension of schizotypy. This may reflect difficulties with generating intentional inferences when the context is insufficiently structured for high schizotypy participants.
References
2013).
(Characteristics of theory of mind Impairments in schizophrenia . In D. L. RobertsD. L. PennEds., Social cognition in schizophrenia (pp. 196–214). Oxford University Press. https://doi.org/10.1093/med:psych/9780199777587.003.00082012). Associations between cognitive biases and domains of schizotypy in a non-clinical sample. Psychiatry Research, 196(1), 115–122. https://doi.org/10.1016/j.psychres.2011.09.019
(2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev).
. (2013). Contextual social cognition impairments in schizophrenia and bipolar disorder. PLoS One, 8(3), Article e57664. https://doi.org/10.1371/journal.pone.0057664
(1956). Test de vocabulaire: manuel d’application
([Vocabulary test: Application manual] . Editions du Centre de psychologie appliquée. https://books.google.fr/books?id=1H3rXwAACAAJ2020). Theory of mind and schizotypy: A meta-analysis. Schizophrenia Research, 222, 97–103. https://doi.org/10.1016/j.schres.2020.04.024
(2011). The study of social cognition with neuroimaging methods as a means to explore future directions of deficit evaluation in schizophrenia? Psychiatry Research, 190(1), 23–31. https://doi.org/10.1016/j.psychres.2010.11.029
(2015). Theory of mind and context processing in schizophrenia: The role of social knowledge. Frontiers in Psychiatry, 6, Article 98. https://doi.org/10.3389/fpsyt.2015.00098
(2012). Theory of mind and context processing in schizophrenia: The role of cognitive flexibility. Psychiatry Research, 200(2–3), 184–192. https://doi.org/10.1016/j.psychres.2012.06.011
(2008). Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia. Schizophrenia Research, 99(1–3), 111–118. https://doi.org/10.1016/j.schres.2007.11.012
(2015). Schizotypy as an organizing framework for social and affective sciences. Schizophrenia Bulletin, 41(suppl 2), S427–S435. https://doi.org/10.1093/schbul/sbu195
(2006). The functional significance of social cognition in schizophrenia: A review. Schizophrenia Bulletin, 32(Supplement 1), S44–S63. https://doi.org/10.1093/schbul/sbl029
(2016). Impaired context processing during irony comprehension in schizotypy: An ERPs study. International Journal of Psychophysiology, 105, 17–25. https://doi.org/10.1016/j.ijpsycho.2016.04.009
(2013). An event-related potential study of predictive and integrative semantic context processing in subjects with schizotypal traits. Psychophysiology, 50(11), 1109–1119. https://doi.org/10.1111/psyp.12124
(2000). Validation of the French version of the Raine Schizotypal Personality Disorder Questionnaire – categorial and dimensional approach to schizotypal personality traits in a normal student population. L’Encéphale, 26(5), 23–29.
(2014). Genetics, cognition, and neurobiology of schizotypal personality: A review of the overlap with schizophrenia. Frontiers in Psychiatry, 5, Article 18. https://doi.org/10.3389/fpsyt.2014.00018
(1999). Right words and left words: Electrophysiological evidence for hemispheric differences in meaning processing. Brain Research: Cognitive Brain Research, 8(3), 373–392. https://doi.org/10.1016/s0926-6410(99)00036-1
(2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis. Neuroscience & Biobehavioral Reviews, 35(3), 573–588. https://doi.org/10.1016/j.neubiorev.2010.07.001
(2011). Theory of mind and psychometric schizotypy. Psychiatry Research, 188(2), 217–223. https://doi.org/10.1016/j.psychres.2011.04.029
(1983). New method for off-line removal of ocular artifact. Electroencephalography and Clinical Neurophysiology, 55(4), 468–484. https://doi.org/10.1016/0013-4694(83)90135-9
(2008). Social cognition in schizophrenia: An NIMH workshop on definitions, assessment, and research opportunities. Schizophrenia Bulletin, 34(6), 1211–1220. https://doi.org/10.1093/schbul/sbm145
(2005). Context processing and social cognition in schizophrenia. Current Psychiatry Reviews, 1(1), 11–22. https://doi.org/10.2174/1573400052953529
(2003). The cognitive basis of disorganization symptomatology in schizophrenia and its clinical correlates: Toward a pathogenetic approach to disorganization. Schizophrenia Bulletin, 29(3), 459–471.
(2008). Empathy, social functioning and schizotypy. Psychiatry Research, 160(1), 15–22. https://doi.org/10.1016/j.psychres.2007.04.014
(2010). Schizotypy and language: A review. Journal of Neurolinguistics, 23(3), 193–203. https://doi.org/10.1016/j.jneuroling.2009.03.002
(2005). Association of schizotypy with semantic processing differences: An event-related brain potential study. Schizophrenia Research, 77(2–3), 329–342. https://doi.org/10.1016/j.schres.2005.03.021
(2014). Event-related brain potential study of expectancy and semantic matching in schizotypy. International Journal of Psychophysiology, 92(2), 67–73. https://doi.org/10.1016/j.ijpsycho.2014.02.006
(2003). Functional analysis of the deficit in semantic context processes in schizophrenic patients: An event-related potentials study. Neurophysiologie Clinique/Clinical Neurophysiology, 33(1), 11–22.
(2010). What can event-related potentials tell us about language, and perhaps even thought, in schizophrenia? International Journal of Psychophysiology, 75(2), 66–76. https://doi.org/10.1016/j.ijpsycho.2009.09.005
(2011). Thirty years and counting: Finding Meaning in the N400 component of the event-related brain potential (ERP). Annual Review of Psychology, 62(1), 621–647. https://doi.org/10.1146/annurev.psych.093008.131123
(1999). Mentalising, schizotypy, and schizophrenia. Cognition, 71(1), 43–71. https://doi.org/10.1016/s0010-0277(99)00018-9
(2013). Social cognition in first-degree relatives of people with schizophrenia: A meta-analysis. Psychiatry Research, 209(2), 129–135. https://doi.org/10.1016/j.psychres.2012.11.037
(2013). N400 in schizophrenia patients. Current Opinion in Psychiatry, 26(2), 196–207. https://doi.org/10.1097/YCO.0b013e32835d9e56
(2013). A multidimensional assessment of social cognition in psychometrically defined schizotypy. Psychiatry Research, 210(3), 1014–1019. https://doi.org/10.1016/j.psychres.2013.08.020
(1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9(1), 97–113. https://doi.org/10.1016/0028-3932(71)90067-4
(2011). Paranoid induction reduces N400s of healthy subjects with delusional-like ideation: Paranoid induction reduces N400s. Psychophysiology, 48(7), 937–949. https://doi.org/10.1111/j.1469-8986.2010.01160.x
(2010). Schizotypal traits and N400 in healthy subjects. Psychophysiology, 47(6), 1047–1056. https://doi.org/10.1111/j.1469-8986.2010.01016.x
(1991). The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin, 17(4), 555–564. https://doi.org/10.1093/schbul/17.4.555
(2010). Neural correlates of irony comprehension: The role of schizotypal personality traits. Brain and Language, 113(1), 1–12. https://doi.org/10.1016/j.bandl.2009.11.007
(2018). Attribution of intentions and context processing in psychometric schizotypy. Cognitive Neuropsychiatry, 23(6), 364–376. https://doi.org/10.1080/13546805.2018.1528972
(2016). Eye-tracking reveals a slowdown of social context processing during intention attribution in patients with schizophrenia. Journal of Psychiatry & Neuroscience, 41(2), E13–E21. https://doi.org/10.1503/jpn.150045
(2013). Deficits in Domains of social cognition in schizophrenia: A meta-analysis of the empirical evidence. Schizophrenia Bulletin, 39(5), 979–992. https://doi.org/10.1093/schbul/sbs080
(2005). Poor premorbid social functioning and theory of mind deficit in schizophrenia: Evidence of reduced context processing? Journal of Psychiatric Research, 39(5), 499–508. https://doi.org/10.1016/j.jpsychires.2005.01.001
(1998). The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl 20), 22–33.
(2006). Theory of mind and perceptual context‐processing in schizophrenia. Cognitive Neuropsychiatry, 11(4), 416–436. https://doi.org/10.1080/13546800444000272
(2013). Irony comprehension and context processing in schizophrenia during remission – A functional MRI study. Brain and Language, 126(3), 231–242. https://doi.org/10.1016/j.bandl.2013.05.017
(2011). Semantic processing disturbance in patients with schizophrenia: A meta-analysis of the N400 component. PLoS One, 6(10), Article e25435. https://doi.org/10.1371/journal.pone.0025435
(2015). Dimensional schizotypy and social cognition: An fMRI imaging study. Frontiers in Behavioral Neuroscience, 9, Article 133. https://doi.org/10.3389/fnbeh.2015.00133
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