Abstract
Very preterm birth has become more frequent during the past decades due to progress in reproductive medicine, more frequent indicated preterm births due to maternal illnesses, and increasing maternal age. Moreover, survival rates of very preterm children have increased due to improved neonatal management. However, very preterm-born children, adolescents, and young adults are at increased risk for poor cognitive function and socio-emotional problems, which is of growing public health concern. Very premature birth has been studied to unravel consequences of a nonoptimal environment during a developmental period which under normal circumstances would be the last trimester of fetal development. For very preterm children, this developmental period partly occurs outside the womb, which leads to major distress for the immature newborn. For the cerebral cortex, the last trimester of pregnancy is a particularly sensitive period during which cortical folding takes place and the volume increases 4fold. During this period, even minor insults may cascade into disturbances of brain development. The most frequent complication after very preterm birth is related to insufficient functioning of the lungs, which may lead to hypoxic-ischemic incidences and damage to nervous tissue. This review presents evidence for long-term sequels of very premature birth regarding neurocognitive, academic, socio-emotional, and mental health development. Then it discusses possible underlying mechanisms including alterations in brain development, programming of the hypothalamic-pituitary-adrenal axis and circadian rhythmicity, as well as affected parent-child interaction patterns in families with very preterm children. Finally, intervention approaches to improve outcomes after very preterm birth are discussed and directions for future research presented.
References
2009). Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics, 124, 717–728.
(2010). Birth weight, schizophrenia, and adult mental disorder: Is risk confined to the smallest babies? Archives of General Psychiatry, 67, 923–930. doi: 10.1001/archgenpsychiatry.2010.100
(2006). Personality in young adults who are born preterm. Pediatrics, 117, 309–316.
(2002). Fetal origins of adult disease: Strength of effects and biological basis. International Journal of Epidemiology, 31, 1235–1239.
(2011). Language abilities in children who were very preterm and/or very low birth weight: A meta-analysis. The Journal of Pediatrics, 158, 766–774.
(2002). Cognitive and behavioral outcomes of school-aged children who were born preterm: A meta-analysis. The Journal of the American Medical Association, 288, 728–737.
(2013). Development of circadian rhythms: Role of postnatal light environment. Neuroscience and Biobehavioral Reviews, 37, 551–560. doi: 10.1016/j.neubiorev.2013.02.012
(2004). Association of depression with medical illness: Does cortisol play a role? Biological Psychiatry, 55, 1–9.
(2013). Mechanisms of rapid antidepressant effects of sleep deprivation therapy: Clock genes and circadian rhythms. Biological Psychiatry, 73, 1164–1171.
(2011). Prevalence of psychiatric diagnoses in preterm and full-term children, adolescents and young adults: A meta-analysis. Psychological Medicine, 41, 2463–2474.
(2007). Hypothalamic-pituitary-adrenal axis function and the cellular immune response in former preterm children. The Journal of Clinical Endocrinology and Metabolism, 92, 3429–3435.
(2013). Preterm birth and mortality and morbidity: A population-based quasi-experimental study. JAMA Psychiatry, 70, 1231–1240.
(2012). Preterm birth and leisure participation: A synthesis of the literature. Research in Developmental Disabilities, 33, 1211–1220.
(2012). Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis. Developmental Medicine and Child Neurology, 54, 313–323.
(2011). Developmental coordination disorder in school-aged children born very preterm and/or at very low birth weight: A systematic review. Journal of Developmental and Behavioral Pediatrics, 32, 678–687. doi: 10.1097/DBP.0b013e31822a396a
(2010). Diffusion tensor imaging: A review for pediatric researchers and clinicians. Journal of Developmental and Behavioral Pediatrics, 31, 346–356.
(2007). Maternal versus child risk and the development of parent-child and family relationships in five high-risk populations. Development and Psychopathology, 19, 293–312.
(2011). Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America, 108, 14312–14317. doi: 10.1073/pnas.1010943108
(2011). Prematurity, maternal posttraumatic stress and consequences on the mother-infant relationship. Early Human Development, 87, 21–26.
(2006). Early dyadic patterns of mother-infant interactions and outcomes of prematurity at 18 months. Pediatrics, 118, e107–e114.
(2012). Visual perception and visual-motor integration in very preterm and/or very low birth weight children: A meta-analysis. Research in Developmental Disabilities, 33, 726–736.
(2008). Epidemiology and causes of preterm birth. The Lancet, 371, 75–84.
(2005). Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU. Pain, 113, 293–300.
(2002). Outcomes in young adulthood for very-low-birth-weight infants. The New England Journal of Medicine, 346, 149–157.
(2008). Prenatal and neonatal risk factors for sleep disordered breathing in school-aged children born preterm. The Journal of Pediatrics, 153, 176–182.
(2007). Glucose regulation in young adults with very low birth weight. The New England Journal of Medicine, 356, 2053–2063.
(1998). Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Annals of Neurology, 43, 224–235.
(2005). Abnormal cerebral structure is present at term in premature infants. Pediatrics, 115, 286–294.
(2005). Low-birthweight adolescents: Quality of life and parent-child relations. Acta Paediatrica, 94, 1295–1302.
(2012). Mother and child behaviour in very preterm and term dyads at 6 and 8 years. Developmental Medicine and Child Neurology, 54, 716–723.
(2012). Motor learning and working memory in children born preterm: A systematic review. Neuroscience and Biobehavioral Reviews, 36, 1314–1330.
(2002). Prenatal hypoxia impairs circadian synchronisation and response of the biological clock to light in adult rats. The Journal of Physiology, 543, 387–395.
(2008). Young adults with very low birth weight: Leaving the parental home and sexual relationships-Helsinki study of very low birth weight adults. Pediatrics, 122, e62–72. doi: 10.1542/peds.2007-3858
(2010). Early life predictors of the physiological stress response later in life. Neuroscience and Biobehavioral Reviews, 35, 23–32.
(2008). Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age. Pediatrics, 121, e870–e878. doi: 10.1542/peds.2007-2454
(2014). Blunted hypothalamic‐pituitary‐adrenal axis and insulin response to psychosocial stress in young adults born preterm at very low birth weight. Clinical Endocrinology, 80, 101–106. doi: 10.1111/cen.12251
(2012). Meta-analysis of the association between preterm delivery and intelligence. Journal of Public Health, 34, 209–216.
(2012). Strategies in the prevention of preterm births during and before pregnancy. In J. C. MorrisonEd., Preterm birth-mother and child (pp. 245–262). Rijeka, Croatia: InTech. doi: 10.5772/28484
(2012). The effects of preterm birth on mother-infant interaction and attachment during the infant’s first two years. Acta Obstetricia et Gynecologica Scandinavica, 91, 164–173.
(1998). Temperament of preterm infants at 4 months of age: Maternal ratings and perceptions. Journal of Developmental and Behavioral Pediatrics, 19, 391–396.
(2009). Psychiatric morbidity in adolescents and young adults born preterm: A Swedish national cohort study. Pediatrics, 123, e47–e53.
(2011). Preterm birth and attention-deficit/hyperactivity disorder in schoolchildren. Pediatrics, 127, 858–865.
(2006). Early intervention in low birth weight premature infants: Results at 18 years of age for the Infant Health and Development Program. Pediatrics, 117, 771–780.
(2007). Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends in Molecular Medicine, 13, 269–277.
(1997). Parenting the prematurely born child: Pathways of influence. Seminars in Perinatology, 21, 254–266.
(2011). Cycled light in the intensive care unit for preterm and low birth weight infants. Cochrane Database of Systematic Reviews, 1, CD006982. doi: 10.1002/14651858.CD006982.pub2
(2008). Long-term medical and social consequences of preterm birth. The New England Journal of Medicine, 359, 262–273.
(2009). Development of executive function and attention in preterm children: A systematic review. Developmental Neuropsychology, 34, 393–421.
(2013). Self-perceived health status and mental health outcomes in young adults born with less than 1000 g. Acta Paediatrica, 102, 294–299.
(2009). Do early intervention programmes improve cognitive and motor outcomes for preterm infants after discharge? A systematic review. Developmental Medicine and Child Neurology, 51, 851–859.
(2008). Personality of young adults born prematurely: The Helsinki study of very low birth weight adults. Journal of Child Psychology and Psychiatry, 49, 609–617. doi: 0.1111/j.1469-7610.2007.01874.x
(2012). Bronchopulmonary dysplasia: Then and now. Neonatology, 102, 1–8.
(2000). Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension, 35, 1301–1306.
(2009). Behavioral inhibition and behavioral approach in young adults with very low birth weight: The Helsinki study of very low birth weight adults. Personality and Individual Differences, 46, 106–110.
(2010). Romantic attachment in young adults with very low birth weight – the Helsinki study of very low birth weight adults. Journal of Developmental Origins of Health and Disease, 1, 271–278.
(2011). Parental bonding after preterm birth: Child and parent perspectives in the Helsinki study of very low birth weight adults. The Journal of Pediatrics, 158, 251–256.
(2008). Depression in young adults with very low birth weight: The Helsinki study of very low birth weight adults. Archives of General Psychiatry, 65, 290–296.
(2011). The biological basis of injury and neuroprotection in the fetal and neonatal brain. International Journal of Developmental Neuroscience, 29, 551–563.
(2001). Cognition, academic progress, behavior and self-concept at 14 years of very low birth weight children. Journal of Developmental and Behavioral Pediatrics, 22, 11–18.
(2013). Executive functions of children born very preterm – deficit or delay? European Journal of Pediatrics, 172, 473–483.
(2006). Neonatal loss of γ-aminobutyric acid pathway expression after human perinatal brain injury. Journal of Neurosurgery, 104, 396.
(2011). Basic information processing abilities at 11 years account for deficits in IQ associated with preterm birth. Intelligence, 39, 198–209.
(2003). Prevalence and risk factors for sleep-disordered breathing in 8-to 11-year-old children: Association with race and prematurity. The Journal of Pediatrics, 142, 383–389.
(2012). Population based trends in mortality, morbidity and treatment for very preterm-and very low birth weight infants over 12 years. BMC Pediatrics, 12, 17.
(2008). An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet, 371, 261–269.
(2012). Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008. BMC Pediatrics, 12, 198. doi: 10.1186/1471-2431-12-198
. (2008). Shyness and timidity in young adults who were born at extremely low birth weight. Pediatrics, 122, e181–187.
(2010). Longitudinal predictors of maternal stress and coping after very low-birth-weight birth. Archives of Pediatrics & Adolescent Medicine, 164, 518–524. doi: 10.1001/archpediatrics.2010.81
(2012). Anxiety in adolescents born preterm or with very low birthweight: A meta-analysis of case-control studies. Developmental Medicine and Child Neurology, 54, 988–994.
(2012). Early developmental intervention programmes post-hospital discharge to prevent motor and cognitive impairments in preterm infants. Cochrane Database of Systematic Review, 12, CD005495. doi: 10.1002/14651858.CD005495.pub3
(2010). Morningness propensity in young adults born prematurely: The Helsinki study of very low birth weight adults. Chronobiology International, 27, 1829–1842.
(2008). Very low birth weight and behavioral symptoms of attention deficit hyperactivity disorder in young adulthood: The Helsinki study of very-low-birth-weight adults. The American Journal of Psychiatry, 165, 1345–1353. doi: 10.1176/appi.ajp.2008.08010085
(2012). Fortpflanzung, Gesundheit der Neugeborenen – Daten, Indikatoren
. ([Reproduction, neonatal health – data, indicators] . Retrieved from www.bfs.admin.ch/bfs/portal/de/index/themen/14/02/03/key/04.html2007). Temperament and response to the trier social stress test. Acta Psychiatrica Scandinavica, 115, 395–402.
(2008). Childhood parental loss and adult hypothalamic-pituitary-adrenal function. Biological Psychiatry, 63, 1147–1154. doi: 10.1016/j.biopsych.2008.01.011
(2012). Language functions in preterm-born children: A systematic review and meta-analysis. Pediatrics, 129, 745–754.
(2009). Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances. Lancet Neurology, 8, 110–124.
(2007). Parental protection of extremely low birth weight children at age 8 years. Journal of Developmental and Behavioral Pediatrics, 28, 317–326.
(2010). Prevalence of motor-skill impairment in preterm children who do not develop cerebral palsy: A systematic review. Developmental Medicine and Child Neurology, 52, 232–237.
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