Abstract
Zusammenfassung. Ziel der Studie ist die überprüfung der Validität einer Auswertungsmethode von motorischen Herzschlagentdeckungsaufgaben, die zur Messung der kardialen Empfindungsfähigkeit oder Sensitivität neben validen Reaktionen (Treffern) auch invalide Reaktionen berücksichtigt. Die Methode basiert auf der Signalentdeckungstheorie und erlaubt deshalb, die interessierende Sensitivität (d´) unabhängig von der Reaktionsneigung zu berechnen. Zwei Fragen standen im Mittelpunkt: (1.) Ist es möglich, mittels einer P300 im herzschlagevozierten Potenzial valide Reaktionen zu identifizieren; und (2.) ist d´ ein valider Kennwert der kardialen Sensitivität? Die Ergebnisse der Studie sprechen für beide daraus abgeleiteten Annahmen. Mithin erwies sich die P300 als Korrelat der tatsächlichen Herzschlagentdeckung und d´ als ein Kennwert, mit dem man valide gute von schlechten Herzschlagentdeckern trennen kann – sogar besser als anhand eines herkömmlichen Indikators.
Abstract. Bodily perception is becoming increasingly important to neuropsychological theories. If we are to measure such individual interoceptive processes objectively and validly, we need an appropriate method. This study tests the validity of an evaluation method of motor heartbeat detection tasks, which accounts for valid reactions (hits) and invalid reactions in order to obtain a measure of cardiac sensitivity. This method is based on the signal-detection theory, and its sensitivity index (d´) is intended to map actual cardiac sensitivity independently of the individual response bias. Two questions were central: (1) Is it possible to identify valid reactions in the heartbeat evoked potential (HEP) by means of a P300 component? (2) Is d´ a valid indicator of cardiac sensitivity? The results of the current study support both assumptions. Thus, the (visceroceptive) P300 proves to be an indicator of heartbeat detection, and d´ functions as a parameter for separating good from bad heartbeat detectors – and in doing so it performs even better than a (comparatively good) conventional parameter. The study validates d´ as a measure of cardiac sensitivity and provides new insights into the functional significance of the HEP as a signature of cortical processing of afferent cardiovascular signals.
Literatur
2014). Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula. Biological Psychiatry, 76, 258–266. https://doi.org/10.1016/j.biopsych.2013.11.027
(2018). Altered interoceptive activation before, during, and after aversive breathing load in women remitted from anorexia nervosa. Psychological Medicine, 48, 142–154. https://doi.org/10.1017/S0033291717001635
(2016). Testing the importance of the Medial Temporal Lobes in human interoception: Does it matter if there is a memory component to the task? Neuropsychologia, 91, 371–379. https://doi.org/10.1016/j.neuropsychologia.2016.09.005
(2016). Towards a psychophysics of interoceptive processes: The measurement of heartbeat detection. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1708), 20160015. https://doi.org/10.1098/rstb.2016.0015
(2001). Interoception: The inside story – A model for psychosomatic processes. Psychosomatic Medicine, 63, 697–710. https://doi.org/10.1097/00006842-200109000-00001
(2015). Auditory feedback differentially modulates behavioral and neural markers of objective and subjective performance when tapping to your heartbeat. Cerebral Cortex, 25, 4490–4503. https://doi.org/10.1093/cercor/bhv076
(1977). Cardiac perception and cardiac control – A review. Biofeedback and Self-Regulation, 4, 349–369. https://doi.org/10.1007/BF00998622
(2002). Strokes restricted to the insular cortex. Neurology, 59, 1950–1955. https://doi.org/10.1212/01.WNL.0000038905.75660.BD
(1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Lawrence Earlbaum Associates.
(1990).
(Event-related brain potentials . In J. T. Cacioppo & L. G. Tassinary (Eds.), Principles of psychophysiology: Physical, social, and inferential elements. (pp. 413–455). Cambridge: Cambridge University Press. https://doi.org/10.1017/CBO9780511546396.0042015). Heart evoked potential triggers brain responses to natural affective scenes: A preliminary study. Autonomic Neuroscience: Basic and Clinical, 193, 132–137. https://doi.org/10.1016/j.autneu.2015.06.006
(2013). The man who feels two hearts: The different pathways of interoception. Social Cognitive and Affective Neuroscience, 9, 1253–1260. https://doi.org/10.1093/scan/nst108
(2002). How do you feel? Interoception: The sense of the physiological condition of the body. Nature Reviews Neuroscience, 3, 655–666. https://doi.org/10.1038/nrn894
(2017). Interoception and emotion. Current Opinion in Psychology, 17, 7–14. https://doi.org/10.1016/j.copsyc.2017.04.020
(2018). The influence of physiological signals on cognition. Current Opinion in Behavioral Sciences, 19, 13–18. https://doi.org/10.1016/j.cobeha.2017.08.014
(2004). EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods, 134, 9–21. https://doi.org/10.1016/j.jneumeth.2003.10.009
(1997). Cardiac field effects on the EEG. Electroencephalography and Clinical Neurophysiology, 108, 299–305. https://doi.org/10.1016/S0013-4694(96)96506-2
(1981). Surprise! … Surprise? Psychophysiology, 18, 493–513. https://doi.org/10.1111/j.1469-8986.1981.tb01815.x
(1996). A new brain region for coordinating speech articulation. Nature, 384, 159–161. https://doi.org/10.1038/384159a0
(2001). Functional compensation of the left dominant insula for language. NeuroReport, 12, 2159–2163. https://doi.org/10.1097/00001756-200107200-00023
(1977). On quantifying surprise: The variation of event-related potentials with subjective probability. Psychophysiology, 14, 456–467. https://doi.org/10.1111/j.1469-8986.1977.tb01312.x
(2010). Listening to your heart. Psychological Science, 21, 1835–1844. https://doi.org/10.1177/0956797610389191
(2011). Association between interoception and empathy: Evidence from heartbeat-evoked brain potential. International Journal of Psychophysiology, 79, 259–265. https://doi.org/10.1016/j.ijpsycho.2010.10.015
(2016). Feeling, learning from and being aware of inner states: Interoceptive dimensions in neurodegeneration and stroke. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1708), 20160006. https://doi.org/10.1098/rstb.2016.0006
(2019). Affective interoceptive inference: Evidence from heart-beat evoked brain potentials. Human Brain Mapping, 40, 20–33. https://doi.org/10.1002/hbm.24352
(2008). Olkin’s new formula for significance of r 13 vs. r 23 compared with Hotelling’s method. American Educational Research Journal, 7, 189–195. https://doi.org/10.3102/00028312007002189
(1994). Perception of visceral sensations: A review of recent findings, methodologies, and future directions. Advances in Psychophysiology: A Research Annual, 5, 55–191.
(2013). Heart cycle-related effects on event-related potentials, spectral power changes, and connectivity patterns in the human ECoG. NeuroImage, 81, 178–190. https://doi.org/10.1016/j.neuroimage.2013.05.042
(2018). Interoception and mental health: A roadmap. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 501–513. https://doi.org/10.1016/j.bpsc.2017.12.004
(2009). Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness. International Journal of Psychophysiology, 72, 34–45. https://doi.org/10.1016/j.ijpsycho.2008.08.010
(1992). A comparison between two methods for assessing heartbeat perception. Psychophysiology, 29, 218–222. https://doi.org/10.1111/j.1469-8986.1992.tb01689.x
(2001). The heartbeat-evoked brain potential in patients suffering from diabetic neuropathy and in healthy control persons. Clinical Neurophysiology, 112, 674–682. https://doi.org/10.1016/S1388-2457(01)00480-1
(2018). Interoception is associated with heartbeat-evoked brain potentials (HEPs) in adolescents. Biological Psychology, 137, 24–33. https://doi.org/10.1016/j.biopsycho.2018.06.007
(2007). Randomization, bootstrap and Monte Carlo methods in biology. London: Chapman & Hall.
(2018). Cardiac interoceptive learning is modulated by emotional valence perceived from facial expressions. Social Cognitive and Affective Neuroscience, 13, 677–686. https://doi.org/10.1093/SCAN/NSY042
(2013). Preliminary evidence about the effects of meditation on interoceptive sensitivity and social cognition. Behavioral and Brain Functions, 9, 47. https://doi.org/10.1186/1744-9081-9-47
(1984). Laterality, emotionality, and heartbeat perception. Psychophysiology, 21, 459–465. https://doi.org/10.1111/j.1469-8986.1984.tb00227.x
(1993). Heartbeat evoked potentials (HEP): Topography and influence of cardiac awareness and focus of attention. Electroencephalography and Clinical Neurophysiology/Evoked Potentials, 88, 163–172. https://doi.org/10.1016/0168-5597(93)90001-6
(2003). Nonparametric Permutation Tests for Functional Neuroimaging. In R. S. J. Frackowiak (Eds.), Human Brain Function. (pp. 887–910). Frisco: Elsevier Inc. https://doi.org/10.1016/B978-012264841-0/50048-2.
(2014). The role of the insula in speech and language processing. Brain and Language, 135, 96–103. https://doi.org/10.1016/j.bandl.2014.06.003
(2018). Neural sources and underlying mechanisms of neural responses to heartbeats, and their role in bodily self-consciousness: An intracranial EEG study. Cerebral Cortex, 28, 2351–2364. https://doi.org/10.1093/cercor/bhx136
(2014). Spontaneous fluctuations in neural responses to heartbeats predict visual detection. Nature Neuroscience, 17, 612–618. https://doi.org/10.1038/nn.3671
(2014). The neural subjective frame: From bodily signals to perceptual consciousness. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1641), 20130208. https://doi.org/10.1098/rstb.2013.0208
(2018). Focus of attention modulates the heartbeat evoked potential. NeuroImage, 186, 595–606. https://doi.org/10.1016/j.neuroimage.2018.11.037
(1987). Task difficulty, probability, and inter-stimulus interval as determinants of P300 from auditory stimuli. Electroencephalography and Clinical Neurophysiology/Evoked Potentials, 68, 311–320. https://doi.org/10.1016/0168-5597(87)90052-9
(2005a). Brain structures involved in interoceptive awareness and cardioafferent signal processing: A dipole source localization study. Human Brain Mapping, 26, 54–64. https://doi.org/10.1002/hbm.20121
(2005b). On the relationship between interoceptive awareness, emotional experience, and brain processes. Cognitive Brain Research, 25, 948–962. https://doi.org/10.1016/j.cogbrainres.2005.09.019
(2004). Accuracy of heartbeat perception is reflected in the amplitude of the heartbeat-evoked brain potential. Psychophysiology, 41, 476–482. https://doi.org/10.1111/1469-8986.2004.00170.x
(2018). Zur Anwendung der Signalentdeckungstheorie bei der Auswertung von Aufgaben zur motorischen Verfolgung der eigenen Herzschläge. Diagnostica, 64, 97–108. https://doi.org/10.1026/0012-1924/a000195
(1996). Influence of beliefs about heart rate and actual heart rate on heartbeat counting. Psychophysiology, 33, 541–546. https://doi.org/10.1111/j.1469-8986.1996.tb02430.x
(2018). Heartbeat counting is unrelated to heartbeat detection: A comparison of methods to quantify interoception. Psychophysiology, 55, e13084. https://doi.org/10.1111/psyp.13084
(2015). Effects of heartbeat feedback on beliefs about heart rate and heartbeat counting: A cautionary tale about interoceptive awareness. Biological Psychology, 104, 193–198. https://doi.org/10.1016/j.biopsycho.2014.12.010
(2018). Altered neural signatures of interoception in multiple sclerosis. Human Brain Mapping, 39, 4743–4754. https://doi.org/10.1002/hbm.24319
(2019). Interoceptive sensibility tunes risk-taking behaviour when body-related stimuli come into play. Scientific Reports, 9, 2369. https://doi.org/10.1038/s41598-019-39061-0
(1981). Heart beat perception and emotional experience. Psychophysiology, 18, 483–488. https://doi.org/10.1111/j.1469-8986.1981.tb02486.x
(1996). Event-related brain potentials and the processing of cardiac activity. Biological Psychology, 42, 75–85. https://doi.org/10.1016/0301-0511(95)05147-3
(1986). From the heart to the brain: A study of heartbeat contingent scalp potentials. International Journal of Neuroscience, 30, 261–275. https://doi.org/10.3109/00207458608985677
(1990). Enhancement of heartbeat-related brain potentials through cardiac awareness training. International Journal of Neuroscience, 53, 243–253. https://doi.org/10.3109/00207459008986611
(2015). Short-term food deprivation increases amplitudes of heartbeat-evoked potentials. Psychophysiology, 52, 695–703. https://doi.org/10.1111/psyp.12388
(2016). Neural correlates of heart-focused interoception: A functional magnetic resonance imaging meta-analysis. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1708), 20160018. https://doi.org/10.1098/rstb.2016.0018
(2014). How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder. PLoS ONE, 9, e98769. https://doi.org/10.1371/journal.pone.0098769
(1988). Bilateral opercular syndrome and crossed aphemia due to a right insular lesion: A clinicopathological study. Brain and Language, 34, 253–261. https://doi.org/10.1016/0093-934X(88)90137-X
(2018). Hippocampal dependent neuropsychological tests and their relationship to measures of cardiac and self-report interoception. Brain and Cognition, 123, 23–29. https://doi.org/10.1016/j.bandc.2018.02.008
(1965). Evoked-potential correlates of stimulus uncertainty. Science, 150(3700), 1187–1188. https://doi.org/10.1126/science.150.3700.1187
(2014). Dynamic changes in phase-amplitude coupling facilitate spatial attention control in fronto-parietal cortex. PLoS Biology, 8, e1001936. https://doi.org/10.1371/journal.pbio.1001936
(2013). How does interoceptive awareness interact with the subjective experience of emotion? An fMRI study. Human Brain Mapping, 34, 598–612. https://doi.org/10.1002/hbm.21458
(2009). INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia. Journal of the International Neuropsychological Society, 15, 777–786. https://doi.org/10.1017/S1355617709990415
(2016). Interoception beyond homeostasis: Affect, cognition and mental health. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1708), 20160002. https://doi.org/10.1098/rstb.2016.0002
(1982). Die Signalentdeckungstheorie in der Psychologie. Stuttgart: Kohlhammer.
(1998). Psychophysiologie. Stuttgart: Kohlhammer.
(2018). Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions. Human Brain Mapping, 39, 1563–1581. https://doi.org/10.1002/hbm.23933
(2015). The roles of interoceptive sensitivity and metacognitive interoception in panic. Behavioral and Brain Functions, 8, 11–14. https://doi.org/10.1186/s12993-015-0058-8
(2017). The inner world of overactive monitoring: Neural markers of interoception in obsessive-compulsive disorder. Psychological Medicine, 47, 1957–1970. https://doi.org/10.1017/S0033291717000368
(2018). Interoceptive accuracy scores from the heartbeat counting task are problematic: Evidence from simple bivariate correlations. Biological Psychology, 137, 12–17. https://doi.org/10.1016/j.biopsycho.2018.06.006
(