Cannabis and Its Different Strains
Do They Have Differential Effects on Time Perception?
Abstract
Abstract. Previous studies show how time perception can be altered by cannabis consumption, but it is not clear yet whether cannabis produces temporal underproductions or overproductions after acute cannabis intoxication. The present study aimed to analyze a sample of 50 regular cannabis users controlling for cannabis strain (sativa, indica, and hybrid) and to compare their scores in a temporal production task before and after consuming cannabis with a control group of 49 nonusers. Results showed that cannabis intake leads to overproductions, suggesting that regular users’ internal tempo slows down after acute intoxication. However, the analyses of main effects showed that indica users, both at baseline levels and after consuming, reported significant underproductions compared to controls, sativa, and hybrid users, and the cannabis-induced effects had a higher magnitude after smoking in the indica-strain group. Results highlight the relevance of including the type of strain consumed in cannabis studies, and they are discussed in terms of short- and long-term alterations in temporal perception under the light of the self-medication theory and the therapeutic uses of cannabis.
References
2006). Cannabinoids in medicine: A review of their therapeutic potential. Journal of Ethnopharmacology, 105(1–2), 1–25. 10.1016/j.jep.2006.02.001
(1999). The effects of cannabinoids on the brain. Progress in Neurobiology, 58(4), 315–348. 10.1016/s0301-0082(98)00087-2
(2007). Testing the self-medication hypothesis of depression and aggression in cannabis-dependent subjects. Psychological Medicine, 37(7), 935–945. 10.1017/s0033291706009688
(2012). The effect of cannabis on perception of time: A critical review. Current Pharmaceutical Design, 18(32), 4915–4922. 10.2174/138161212802884852
(1973). Cannabis and alcohol: Effects on estimation of time and distance. Psychopharmacologia, 32(4), 373–381. 10.1007/bf00429474
(1972). Social facilitation of marijuana intoxication: Impact of social set and pharmacological activity. Journal of Abnormal Psychology, 80(2), 132–140. 10.1037/h0033317
(2011). Self-medication and addictions. In A. AdanC. Vilanou (Eds.), Substance abuse treatment (pp. 51–57). Marge Médica Books.
(2013). Insiders? The experiences and perspectives of long-term, regular cannabis users. Contemporary Drug Problems, 40(2), 235–257. 10.1177/009145091304000205
(1970). Behavioral effects of marihuana: Experimental studies. Archives of General Psychiatry, 23(3), 193–198. 10.1001/archpsyc.1970.01750030001001
(1972). 9-Tetrahydrocannabinol: Dose-related effects on timing behavior in chimpanzee. Science, 175(4021), 547–550. 10.1126/science.175.4021.547
(2006). The attentional mechanism of temporal orienting: Determinants and attributes. Experimental Brain Research, 169(1), 58–68. 10.1007/s00221-005-0131-x
(2016). Sex differences in cannabis use and effects: A cross-sectional survey of cannabis users. Cannabis and Cannabinoid Research, 1(1), 166–175. 10.1089/can.2016.0010
(1976). Acute effects of cannabis on cognitive, perceptual, and motor performance in chronic hashish users. Annals of the New York Academy of Sciences, 282(1), 313–322. 10.1111/j.1749-6632.1976.tb49906.x
(1994). The effects of smoked marijuana on progressive-interval schedule performance in humans. Journal of the Experimental Analysis of Behavior, 62(1), 73–87. 10.1901/jeab.1994.62-73
(2015). The European cannabis social clubs. https://www.encod.org/info/The-EuropeanCannabis-Social-Clubs.html
. (1984). Scalar timing in memory. Annals of the New York Academy of Sciences, 423(1), 52–77. 10.1111/j.1749-6632.1984.tb23417.x
(1996). Do patients use marijuana as an antidepressant? Depression, 4(2), 77–80. 10.1002/(sici)1522-7162(1996)4:2<77::aid-depr7>3.0.co;2-c
(2007). Self-medication hypothesis of substance use: Testing Khantzian's updated theory. Journal of Psychoactive Drugs, 39(2), 151–158. 10.1080/02791072.2007.10399873
(2001). Cannabinoid modulation of time estimation in the rat. Behavioral Neuroscience, 115(1), 243–246. 10.1037/0735-7044.115.1.243
(1984). Cannabis, atropine, and temporal information processing. Neuropsychobiology, 12(4), 229–237. 10.1159/000118144
(2004). A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). American Journal of Botany, 91(6), 966–975. 10.3732/ajb.91.6.966
(1974). Cannabidiol interferes with the effects of Δ9-tetrahydrocannabinol in man. European Journal of Pharmacology, 28(1), 172–177. 10.1016/0014-2999(74)90129-0
(2009). Estimating the size of the global drug market: A demand-side approach. A Report on Global Illicit Drug Markets, 1998–2007, 25(5), 59–78. https://www.rand.org/content/dam/rand/pubs/technical_reports/2009/RAND_TR711.pdf
(2006). Effects of marijuana on temporal discriminations in humans. Behavioural Pharmacology, 17(2), 173–183. 10.1097/01.fbp.0000197458.08892.fc
(2016). Genomic and chemical diversity in Cannabis. Critical Reviews in Plant Sciences, 35(5–6), 349–363. 10.1080/07352689.2016.1265363
(1998). Cerebellar activity and disturbed time sense after THC. Brain Research, 797(2), 183–189. 10.1016/s0006-8993(98)00375-8
(2004). The neural basis of temporal processing. Annual Review Neuroscience, 27, 307–340. 10.1146/annurev.neuro.27.070203.144247
(2003). Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology, 28(7), 1356–1365. 10.1038/sj.npp.1300176
(2017). Models of cannabis taxonomy, cultural bias, and conflicts between scientific and vernacular names. The Botanical Review, 83(4), 327–381. 10.1007/s12229-017-9187-0
(1978). Some psychological correlates of long–term heavy cannabis users. The British Journal of Psychiatry, 132(5), 482–486. 10.1192/bjp.132.5.482
(1971). Administration of marijuana to heavy and casual marijuana users. American Journal of Psychiatry, 128(2), 198–204. 10.1176/ajp.128.2.198
(2015). Age, sex and personality in early cannabis use. European Psychiatry, 30(4), 469–473. 10.1016/j.eurpsy.2015.02.008
(2003). Marijuana alters the human cerebellar clock. Neuroreport, 14(8), 1145–1151. 10.1097/01.wnr.0000075420.59944.20
(2012). High time. The Psychologist, 25(8), 590–593. https://thepsychologist.bps.org.uk/volume-25/edition-8/high-time
(2016). Cannabis Social Clubs through the lens of the drug user movement. Tijdschrift Over Cultuur and Criminaliteit, 6(2), 47–58. 10.5553/tcc/221195072016006002003
(2008). Cannabinoid modulation of executive functions. European Journal of Pharmacology, 585(2–3), 458–463. 10.1016/j.ejphar.2008.02.099
(2014). Discriminating the effects of cannabis sativa and cannabis indica: A web survey of medical cannabis users. The Journal of Alternative and Complementary Medicine, 20(10), 787–791. 10.1089/acm.2013.0190
(1991). The pharmacologic effects of daily marijuana smoking in humans. Pharmacology, Biochemistry, and Behavior, 40(3), 691–694. 10.1016/0091-3057(91)90384-e
(2011). What is the best and easiest method of preventing counting in different temporal tasks? Behavioural Research Methods, 44(1), 67–80. 10.3758/s13428-011-0135-3
(2016). Bayesian inference for the distribution of grams of marijuana in a joint. Drug and Alcohol Dependence, 165, 175–180. 10.1016/j.drugalcdep.2016.06.004
(2001). Therapeutic aspects of cannabis and cannabinoids. The British Journal of Psychiatry, 178(2), 107–115. 10.1192/bjp.178.2.107
(2016). Current therapeutic cannabis controversies and clinical trial design issues. Frontiers in Pharmacology, 7, 309. 10.3389/fphar.2016.00309
(1988). Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests. Journal of Pharmacology and Experimental Therapeutics, 245(1), 178–186. https://jpet.aspetjournals.org/content/jpet/245/1/178.full.pdf
(2019). Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: Implications for a budding industry. Journal of Cannabis Research, 1(1), 3. 10.1186/s42238-019-0001-1
(2013). Acute effects of THC on time perception in frequent and infrequent cannabis users. Psychopharmacology, 226(2), 401–413. 10.1007/s00213-012-2915-6
(2002). Cognitive functioning of long-term heavy cannabis users seeking treatment. Journal of the American Medical Association, 287(9), 1123–1131. 10.1001/jama.287.9.1123
(2010). Delta-9-tetrahydrocannabinol disruption of time perception and of self-timed actions. Pharmacopsychiatry, 43(6), 236–237. 10.1055/s-0030-1255030
(1972). Marihuana and alcohol, time production and memory functions. Archives of General Psychiatry, 27(6), 812–815. 10.1001/archpsyc.1972.01750300074013
(1976). Marijuana and ethanol: Differential effects on time perception, heart rate, and subjective response. Psychopharmacology, 49(3), 275–279. 10.1007/bf00426830
(2018). World Drug Report 2018 Global Overview of Drug Demand and Supply. https://www.unodc.org/wdr2018/prelaunch/WDR18_ExSum_Spanish.pdf
. (1974). Marihuana effects on learning, attention and time estimation. Psychopharmacologia, 39(1), 1–11. 10.1007/bf00421453
(2017). Medical cannabis and mental health: A guided systematic review. Clinical Psychology Review, 51, 15–29. 10.1016/j.cpr.2016.10.002
(1991). Do humans possess an internal clock with scalar timing properties? Learning and Motivation, 22(1–2), 59–83. 10.1016/0023-9690(91)90017-3
(2005). The wrong tree: Time perception and time experience in the elderly. In J. DuncanL. PhillipsP. McLeod (Eds.), Measuring the mind: speed, control, and age (pp. 137–158). Oxford University Press.
(1968). Clinical and psychological effects of marihuana in man. Science, 162(3859), 1234–1242. 10.1126/science.162.3859.1234
(2008). Decision making, impulsivity and time perception. Trends in Cognitive Sciences, 12(1), 7–12. 10.1016/j.tics.2007.10.004
(2016). Health and social effects of nonmedical cannabis use. World Health Organization. https://apps.who.int/iris/bitstream/handle/10665/251056/9789241510240-eng.pdf;jsessionid=80F338A25436D416C949EF7F06A9A054?sequence=1
. (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310(20), 2191–2194. 10.1001/jama.2013.281053
. (2018). Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. International Journal of Molecular Sciences, 19(3), 833. 10.3390/ijms19030833
(2006). History of cannabis as a medicine: A review. Brazilian Journal of Psychiatry, 28(2), 153–157. 10.1590/s1516-44462006000200015
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