Abstract
Episodische Gedächtnisdefizite, wie etwa Abweichungen im Detailreichtum, in der Erinnerungshäufigkeit und –beeinflussbarkeit werden seit vielen Jahren bei Patienten mit Autismus-Spektrum-Störungen (ASD) beschrieben. Dabei sind Ursachen dieser Defizite noch relativ unerforscht. Vermutet werden Abweichungen in neuronalen Gedächtniskorrelaten wie dem Temporallappen (insbesondere Hippocampus), dem präfrontalen Kortex sowie dem Cingulum. Vorliegender Übersichtsartikel stellt Ergebnisse der normalen Entwicklung episodischer Gedächtnisleistungen bei Kindern und Jugendlichen sowie der experimentellen Gedächtnisforschung bei Patienten mit ASD vor. Klinische Implikationen für den Umgang mit repetitiven Fragen und eingeschränkten sozialen Konfliktlösemöglichkeiten auf Grund von Einschränkungen im episodischen Gedächtnis bei ASD werden diskutiert.
Deficits in episodic memory (EM) such as quality, quantity, and suggestibility of memories have been described in patients with autistic spectrum disorders (ASD) for years. However, the origins of these deficits remain rather unexplored. Changes in neuronal correlates of memory processes, such as the medial temporal lobe, prefrontal cortex, and cingulate gyrus, could cause these deficits. In this review the typical development of memory in children and adolescents is summarized, followed by a description of results of research on memory processes in ASD. Clinical implications of the memory deficits in ASD such as repetitive patterns of communication and low social problem-solving abilities are discussed.
Literatur
1999). MRI volumes of amydala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145 – 2150.
(1995). Mindblindedness. Cambridge MA: MIT Press.
(1996). What do infants recall of their lives? Memory for specific events by one- to two-year-olds. The American Psychologist, 51, 29 – 41.
(1996). Intact and impaired memory functions in autism. Child Development, 67, 1816 – 1835.
(2003). Memory in autism: Review and synthesis. Cortex, 39, 1129 – 1138.
(1981). Immediate free recall in early childhood autism: Another point of behavioural similarity with the amnesic syndrome. British Journal of Psychology, 72, 211 – 215.
(1989). Memory impairments and communication in relatively able autistic children. Journal of Child Psychology and Psychiatry, 30, 99 – 122.
(1976). Memory deficits in early infantile autism: Some similarities to the amnesic syndrome. British Journal of Psychology, 67, 73 – 87.
(2000a). Episodic memory and remembering in adults with Asperger’s syndrome. Journal of Autism and Developmental Disorders, 30, 305 – 316.
(2007). Autobiographical memory and suggestibility in children with autism spectrum disorder. Development and Psychopathology, 19, 73 – 95.
(2000). The construction of autobiographical memories in the self-memory system. Psychological Review, 107, 261 – 288.
(2008). Episodic and semantic autobiographical memory in adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 38, 498 – 506.
(2007). Mapping early brain development in autism. Neuron, 56, 399 – 413.
(1998). Neuropsychological correlates of early symptoms of autism. Child Development, 69, 1276 – 1285.
(1998). Source monitoring by children with autism. Journal of Autism and Developmental Disorders, 28, 43 – 50.
(1996). Neuropsychological and language findings. In , Preschool children with inadequate communication: Developmental language disorder, autism, low IQ (pp. 123 – 154). London: Mac Keith Press.
(1996). Cerebral representation of one’s own past: Neural networks involved in autobiographical memory. Journal of Neurosciences, 16, 4275 – 4282.
(1987). Two-year-olds talk about the past. Cognitive Development, 2, 393 – 409.
(1985). Confusions between memories for performed and imagined actions: A developmental comparison. Child Development, 56, 1145 – 1155.
(1992). Childrens time memory: The development of a differentiated past. Cognitive Development, 7, 171 – 187.
(1970a). Studies in pattern detection in normal and autistic children: I. Immediate recall of auditory sequences. Journal of Abnormal Psychology, 76, 413 – 420.
(1970b). Studies in pattern detection in normal and autistic children: II. Reproduction and production of color sequences. Journal of Experimental Child Psychology, 10, 120 – 135.
(1989). Autism: Explaining the Enigma. Oxford: Blackwell Scientific Publications.
(1994). Autism: Beyond “theory of mind”. Cognition, 50, 115 – 32.
(2001). Reading the mind in cartoons and stories: An fMRI study of theory of mind in verbal and nonverbal tasks. Neuropsychologia, 38, 11 – 21.
(2003). Further evidence of preserved priming and impaired recall in adults with Asperger’s syndrome. Journal of Autism and Developmental Disorders, 33, 259 – 269.
(2008). Atypical recruitment of medial prefrontal cortex in autism spectrum disorders: An fMRI study of two executive function tasks. Neuropsychologia, 46, 2281 – 2291.
(2004) Remembering our past: Functional neuroanatomy of recollection of recent and very remote personal events. Cerebral Cortex, 14, 1214 – 1125.
(2007). Temporal context memory in high- functioning autism. Autism, 11, 523 – 34.
(2003). Hemispheric asymmetries of memory: The HERA model revisited. Trends in Cognitive Sciences, 7, 241 – 245.
(1999). Autism: Cognitive deficit or cognitive style? Trends in Cognitive Sciences, 3, 216 – 22.
(1996). The neuropsychology of autism. Brain, 19, 1377 – 1400.
(2000). Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. American Journal of Psychiatry, 157, 1994 – 2001.
(2002). Action memory and self-monitoring in children with autism: Self versus other. Infant and Child Development, 11, 159 – 170.
(1993). On resolving the enigma of infantile amnesia. Psychological Bulletin, 113, 305 – 326.
(2003). When autobiographical memory begins. In , Theories of memory (Vol. III). Hove, UK: Psychology Press.
(1981). Reality monitoring. Psychological Review, 88, 67 – 85.
(1993). Source monitoring. Psycological Bulletin, 114, 3 – 28.
(2004). Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. Developmental Medicine and Child Neurology, 46, 760 – 764.
(1991). Developmental changes in memory source monitoring. Journal of Experimental Child Psychology, 52, 297 – 318.
(2003). Do children with autism fail to process information in context? Journal of Child Psychology and Psychiatry, 44, 285 – 300.
(2000). Recall for Self and Other in Autism: Children’s Memory for Events Experienced by Themselves and Their Peers. Journal of Autism and Developmental Disorders, 30, 15 – 28.
(1997). Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinion in Neurobiology, 7, 217 – 27.
(2004). The emergence of autobiographical memory: A social cultural developmental theory. Psychological Review, 111, 486 – 511.
(1998). Left prefrontal activation during episodic remembering: An event-related fMRI study. Neuroreport, 26, 3509 – 3514.
(2005). Source memory in children with autism spectrum disorder. Developmental Neuropsychology, 27, 337 – 360.
(1997). Components of executive function in autism and other disorder. In , Autism as an Executive Disorder (pp. 179 – 211). Oxford University Press.
(1991). Executive function deficits in high functioning autistic individuals: Relationship to theory of mind. Journal of Child Psychology and Psychiatry, 32, 1081 – 1105.
(1995). Episodic memory and autonoetic consciousness: Developmental evidence and a theory of childhood amnesia. Journal of Experimental Child Psychology, 59, 516 – 548.
(2009). Neuropsychologische Diagnostik und Therapie. Kindheit und Entwicklung, 18, 59 – 61.
(2006). Neuropsychologische Diagnostik und Therapie von Aufmerksamkeits- und Gedächtnisstörungen im Kindesalter. Verhaltenstherapie, 16, 112 – 120.
(2008). Laboratory memory tasks and autobiographical recollection: Cognitive and neurofunctional evidence for differential forms of episodic memory. In , Brain mapping research developments (pp. 101 – 127). New York: Nova Science Publishers.
(2003). Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory. Brain, 126, 650 – 668.
(1998). No difference in hippocampus volume detected on magnetic resonance imaging in autistic individuals. Journal of Autism and Developmental Disorders, 28, 105 – 110.
(1996). Patients with schizophrenia remember that an event has occurred, but not when. British Journal of Psychiatry, 168, 427 – 431.
(1977). Self-reference and the encoding of personal information. Journal of Personality and Social Psychology, 35, 677 – 688.
(1996). Agency: Its role in mental development. Hove, UK: Erlbaum.
(1999). Memory for actions in children with autism: Self versus other. Cognitive Neuropsychiatry, 4, 303 – 331.
(2005). The role of the medial temporal lobe in autistic spectrum disorders. European Journal of Neurosciences, 22, 764 – 772.
(1991) The medial temporal lobe memory system. Science, 20, 1380 – 1386.
(1999). Memory for places learned long ago is intact after hippocampal damage. Nature, 12, 675 – 677.
(2002). A lack of self-consciousness in autism. American Journal of Psychiatry, 159, 1422 – 1424.
, et al. (1972). Episodic and semantic memory. In , Organization of Memory (pp. 381 – 403). New York: Academic Press.
(1983). Elements of episodic memory. Oxford: Claredon Press.
(1995). Organization of memory: Quo vadis? In M.S. Gazzaniga (Ed.), The Cognitive Neurosciences (pp. 839 – 847). Cambridge, MA: MIT Press.
(2002). Episodic memory: From mind to brain. Annual Review of Psychology, 53, 1 – 25.
(1997). Differential effects of early hippocampal pathology on episodic and semantic memory. Science, 277, 376 – 380.
(1999). The prefrontal cortex generates the basic constituents of the self. Consciousness and Cognition, 8, 343 – 363.
(1965). Primary Memory. Psychological Review, 72, 89 – 104.
(1996). Depression and the specificity of autobiographical memory. In Remembering our past: Studies in autobiographical memory (pp. 244 – 267). Cambridge: Cambridge University Press.
(1996). The specificity of autobiographical memory and imageability of the future. Memory and Cognition, 24, 116 – 125.
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