Abstract
Zusammenfassung. Depressionen, leichte kognitive Störungen und Demenzen sind besonders bei älteren Menschen häufig assoziiert. Ähnliche neuropathologische Mechanismen scheinen diesen Zusammenhang und die gegenseitigen Einflüsse mindestens teilweise zu erklären. Wir schlagen hier eine Kurzreview der Rolle der Depression als Risikofaktor, Prodrom oder Folge der kognitiven Störungen vor und skizzieren kurz mögliche Behandlungsansätze.
Abstract. Depression, mild cognitive impairment and dementia are frequently associated, particularly in old age. Similar neuropathological mechanisms seem to underlie and partly explain their mutual relationship and influence. We propose a brief review on the role of depression as a risk factor, a prodrome and a consequence of cognitive disorders and provide some thoughts on appropriate care options.
Résumé. La dépression, le trouble cognitif léger et la démence sont fréquemment associés, en particulier chez la personne âgée. Des mécanismes neuropathologiques similaires semblent sous-tendre et expliquer en partie leurs liens et influences réciproques. Nous proposons une brève revue du rôle de la dépression en tant que facteur de risque, prodrome et conséquence des troubles cognitifs et esquissons quelques pistes au sujet de sa prise en charge.
Bibliographie
: What are the causes of late-life depression?Psychiatr Clin North Am 2013; 36: 497–516.
. Maladies chroniques et dépendance fonctionnelle des personnes âgées. Neuchâtel; Obsan, document de travail 25: 2007.
: Neuropsychological changes in melancholic and atypical depression: a systematic review. Neurosci Biobehav Rev 2017; 73: 309–325.
: The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features. Pro Neurobiol 2012; 98: 99–143.
: A meta-analysis of cognitive deficits in first-episode major depressive disorder. J Affect Disord 2012; 140: 113–124.
: Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med 2014; 44: 2029–2040.
, : Longitudinal association of dementia and depression. Am J Geriatr Psychiatry 2015; 23: 897–905.
, .: Frequency of depressive syndromes in elderly individuals with no cognitive impairment, mild cognitive impairment and Alzheimer’s disease dementia in a memory clinic setting. Dement Geriatr Cogn Disord 2016; 42: 135–145.
: The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar disorder. Eur Psychiatry 2013; 28: 349–355.
: Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis. Int J Geriatr Psychiatry 2016; 31: 905–911.
: Depression and the risk of developing dementia. Nat Rev Neurol 2011; 7: 323–331.
: Dementia risk estimates associated with measures of depression: a systematic review and meta-analysis. BMJ Open 2015; 5: e008853.
: Parallels between major depressive disorder and Alzheimer’s disease: role of oxidative stress and genetic vulnerability. Cell Mol Neurobiol 2014; 34: 925–949.
, : Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci 2008; 10: 345–357.
: Amyloid-beta and depression in healthy older adults: a systematic review. Aust N Z J Psychiatry 2015; 49: 36–46.
: Personality traits and behavioural and psychological symptoms in patients with mild cognitive impairment. Dement Geriatr Cogn Disord 2013; 35: 87–97.
: Depression in dementia: epidemiology, mechanisms and treatment. Curr Opin Psychiatry 2011; 24: 461–472.
: Grouping of behavioural and psychological symptoms of dementia. Int J Geriatr Psychiatry 2013; 29: 562–568.
: La dépression dans la population suisse. Neuchâtel; Obsan rapport 56: 2013.
: Trouble dépressif à travers les âges en MPR: outils de dépistage, de diagnostic et de suivi. Rev Med Suisse 2010; 6: 1826–1831.
, : Early intervention to reduce the global health and economic burden of major depression in older adults. Ann Rev Public Health 2012; 33: 123–135.
: Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field. Eur Neuropsychopharmacol 2016; 26: 1845–1867.
