Das Herz im Alter
Abstract
Zusammenfassung. Das Wissen um kardiovaskuläre Veränderungen im Alter und deren therapeutische Optionen ist wichtig. Es kann zur Hypertrophie des linken Ventrikels, zur diastolischen Dysfunktion, Herzklappenveränderungen und pulmonaler Hypertonie kommen. Im Alter entwickeln Patienten häufig eine arterielle Hypertonie. Bei über 100-Jährigen sind valvuläre Veränderungen häufig (Aortenstenose und Mitralinsuffizienz). Das Risiko einer koronaren Herzkrankheit beträgt 35 % für Männer und 24 % für Frauen. Im Alter sind Sinusknotendysfunktion und Vorhofflimmern gehäuft. 25 % aller Schlaganfälle sind kardiale Embolien bei Vorhofflimmern. Kardiale Interventionen bei Betagten werden zunehmend häufiger durchgeführt und beinhalten koronare kathetertechnische Revaskularisationen oder Klappeneingriffe (perkutaner Aortenklappenersatz oder MitraClip). Die optimale Therapie im Alter beinhaltet neben kardiovaskulären Interventionen auch Medikamente und eine Lebensstilmodifikation und dient vor allem der Verbesserung der Lebensqualität.
Abstract. Knowledge of cardiovascular changes in old age and their therapeutic options is important. Old age can lead to hypertrophy of the left ventricle, diastolic dysfunction, heart valve changes and pulmonary hypertension. Patients often develop arterial hypertension. Valvular changes are common in people over 100 years of age (aortic stenosis and mitral insufficiency). The risk of coronary heart disease is 35 % for men and 24 % for women. In old age, sinus node dysfunction and atrial fibrillation are common. 25 % of all strokes are cardiac embolisms in atrial fibrillation. Cardiac interventions in the elderly are increasingly frequent and include coronary catheter revascularization or valve interventions (percutaneous aortic valve replacement or MitraClip). Optimal therapy in old age includes not only cardiovascular interventions also include drugs and a lifestyle modification and mainly serves to improve the quality of life.
Résumé. La connaissance des changements cardiovasculaires en vieil âge et leurs options thérapeutiques est importante. L’âge peut conduire à une hypertrophie du ventricule gauche, la dysfonction diastolique, des changements des valves cardiaques et à l’hypertension pulmonaire. Les patients âgés développent souvent une hypertension artérielle. A l’âge de plus de 100 ans les changements valvulaires les plus fréquents sont la sténose aortique et la régurgitation mitrale. Le risque de maladie coronarienne est de 35 % pour les hommes et de 24 % pour les femmes. Un dysfonctionnement du nœud sinusal et la fibrillation auriculaire deviennent aussi fréquents. 25 % de tous les accidents vasculaires cérébraux sont dus à une embolie d’origine cardiaque dans la fibrillation auriculaire. Les interventions cardiaques chez les personnes âgées sont effectuées plus fréque et comprennent une revascularisation coronaire ou un remplacement de la valve aortique par voie percutanée ou l’insertion d’un dispositif MitraClip. La thérapie optimale chez la personne âgée comprend non seulement les interventions cardiovasculaires mais aussi les médicaments et une modification du style de vie pour améliorer la qualité de vie.
Bibliografie
Aortic valve calcification: determinants and progression in the population. Arterioscler Thromb Vasc Biol 2007; 27: 642–648.
, :Macromolecular Degradation Systems and Cardiovascular Aging. Circ Res 2016; 118: 1577–1592.
:Mitochondria and cardiovascular aging. Circ Res 2012; 110: 1109–1124.
:Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J 2015; 36: 3404–3412.
:High blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs. Curr Hypertens Rep 2013; 15: 134–136.
:Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis. Eur J Clin Invest 2013; 43: 1262–1272.
:Structure of the human tricuspid valve leaflets and its chordae tendineae in unexpected death. A forensic autopsy study of 400 cases. Saudi Med J 2004; 25: 1051–1059.
:Age-related changes of element contents in human mitral and tricuspid valves. Biol Trace Elem Res 1999; 70: 137–147.
, :Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med 2016; 374: 2009–2020.
, :Fresh Fruit Consumption and Major Cardiovascular Disease in China. N Engl J Med 2016; 374: 1332–1343.
:Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study. Clin Nutr2011; 30: 38–43.
, :Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 2005; 111: 2921–2926.
, :Echocardiographic characteristics in patients > or =100 years of age. Am J Cardiol 2007; 100: 1792–1794.
, :Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation 2011; 124: 1783–1791.
, :Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis. J Am Coll Cardiol 2011; 58: 570–576.
, :Intensive lipid-lowering therapy for patients with aortic stenosis. Am J Cardiol 2008; 102: 1571–1576.
:Lifetime risks of cardiovascular disease. N Engl J Med 2012; 366: 321–329.
, :Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. Eur Heart J 2017; 38: 814-824.
, :Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575–1584.
, :A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 2015; 22: 86–99.
, :Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 2005; 112: 2254–2262.
, :Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction. JACC Heart Fail 2014; 2: 113–122.
, :Pathology of the senescent heart: anatomic observations on 237 autopsy studies of patients 90 to 105 years old. Mayo Clin Proc 1988; 63: 552–564.
:Atrial Fibrillation and Cardiovascular Outcomes in the Elderly. Pacing Clin Electrophysiol 2016; 39: 907–913.
.Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 1998; 98: 946–952.
, :Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation 2014; 129: 837–847.
, :Remodeling of the aging heart: Sinus node dysfunction and atrial fibrillation. Herzschrittmacherther Elektrophysiol 2017; 28: 29–38.
:Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction. Front Physiol 2015; 6: 37.
, :Survival and changes in physical ability after coronary revascularization for octa-nonagenerian patients with acute coronary syndrome. Heart Vessels 2011; 26: 385–391.
, :Transcatheter aortic valve implantation in nonagenarians: effective and safe. Eur J Intern Med 2013; 24: 750–755.
:Guidelines on the management of valvular heart disease (version 2012). The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)]. G Ital Cardiol (Rome) 2013; 14: 167–214.
, :Comparison of outcomes of percutaneous MitraClip versus surgical repair or replacement for degenerative mitral regurgitation in octogenarians. Am J Cardiol 2015; 115: 487–492.
, :Permanent atrial fibrillation ablation surgery in patients with advanced age. Indian Pacing Electrophysiol J 2005; 5: 254–262.
:Healthcare utilization and quality of life improvement after ablation of paroxysmal AF in younger and older patients. Pacing Clin Electrophysiol 2017; in print
, :The Impact of Age on 5-Year Outcomes After Atrial Fibrillation Catheter Ablation. J Cardiovasc Electrophysiol 2016; 27: 141–146.
, :Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146–156.
, :Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery. JAMA Cardiol 2016; 1: 314–321.
, :Frailty as a predictor of negative outcomes after cardiac resynchronization therapy. Pacing Clin Electrophysiol 2018.
:Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study. J Am Coll Cardiol 2017; 70: 689–700.
, :Long sleep duration, independent of frailty and chronic Inflammation, was associated with higher mortality: A national population-based study. Geriatr Gerontol Int 2017; 17: 1481–1487.
:Impact of lifelong exercise ’dose’ on left ventricular compliance and distensibility. J Am Coll Cardiol 2014; 64: 1257–1266.
, :The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer’s disease: A meta-analysis. J Clin Neurosci 2016; 33: 32–38.
, :A prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor Ramipril In Aortic Stenosis (RIAS trial). Eur Heart J Cardiovasc Imaging 2015; 16: 834–841.
:Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008; 358: 1887–1898.
, :Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged >/=75 Years: A Randomized Clinical Trial. JAMA 2016; 315: 2673–2682.
, :Cardiovascular safety of metformin and sulfonylureas in patients with different cardiac risk profiles. Heart 2016; 102: 1544–1551.
, :10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577–1589.
, :PREVENT-DM Comparative Effectiveness Trial of Lifestyle Intervention and Metformin. Am J Prev Med 2017.
, :The effect of statins on average survival in randomised trials, an analysis of end point postponement. BMJ Open 2015; 5: e007118.
:Exercise in a Pill: The Latest on Exercise-Mimetics. Brain Plast 2017; 2: 153–169.
:Frequency of cardiac rhythm abnormalities in a half million adults. Circ Arrhythm Electrophysiol 2018; 11: e006273.
, :