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Mini-Review

Frühgeburtsscreening: Was ist wirklich sinnvoll?

Published Online:January 09, 2019https://doi.org/10.1024/1661-8157/a003137

Abstract

Zusammenfassung. Die spontane Frühgeburt ist ein Syndrom, das durch multiple Mechanismen ausgelöst wird. Angesichts der pathophysiologischen Heterogenität der Frühgeburt kann ein einzelner Biomarker nicht die geforderten hohen negativen und positiven Prädiktivwerte aufzeigen. Aus klinischer Sicht hat sich die Anamnese, sonografische Messung der Zervix-Länge und Test auf plazentares Alpha-Microglobulin-1 (PAMG-1) aus dem zervikovaginalen Sekret durchgesetzt. Weitere prospektive, gross angelegte longitudinale Studien müssen die kombinierte Verwendung neuer Biomarker validieren.


Preterm Birth Screening: What Does Really Make Sense?

Abstract. Spontaneous preterm birth is a syndrome triggered by multiple mechanisms. In view of the pathophysiological heterogeneity of preterm birth, a single biomarker cannot show the required high negative and positive predictive values. From a clinical point of view, anamnesis, sonographic measurement of cervical length, and placental alpha-microglobulin-1 (PAMG-1) testing from cervico-vaginal secretion are established. Further prospective, large-scale longitudinal studies must validate the combined use of new biomarkers.


Résumé. La naissance prématurée spontanée est un syndrome déclenché par de multiples mécanismes. Compte tenu de l’hétérogénéité physiopathologique des naissances prématurées, un seul biomarqueur ne peut présenter les valeurs prédictives négatives et positives élevées requises. D’un point de vue clinique, l’anamnèse, la mesure échographique de la longueur cervicale et le dosage placentaire de l’alpha-microglobuline-1 (PAMG-1) de la sécrétion cervico-vaginale se sont établis. D’autres études longitudinales prospectives à grande échelle doivent valider l’utilisation combinée de nouveaux biomarqueurs.

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