Abstract
Zusammenfassung. Die Therapie von Rückenschmerzen, speziell die medikamentöse Schmerztherapie mit Opioiden, führt bei der behandelnden Ärztin/beim behandelnden Arzt oft zum Dilemma. Spezifische Rückenschmerzen werden durch gezielte Bildgebung diagnostiziert und operativ oder medikamentös erfolgreich therapiert. Im Gegensatz dazu können bei nicht-spezifischen Rückenschmerzen unbegründete Bildgebung, zweifelhafte Operationsindikationen und unkontrollierte Medikamentengabe die Schmerzen verstärken. Hier ist die Aufrechterhaltung der Aktivität und die Bewegungstherapie zentral für die Therapie. Beim Einsatz von Opioiden verhält es sich ähnlich. Opioide sind potente Medikamente zur kurzfristigen Schmerztherapie. Langzeitanwendung kann die Schmerzen verstärken und Störungen im Hormonhaushalt mit Einschränkungen der Lebensqualität und Libido bewirken. Ausserdem haben Opioide ein Gewöhnungs- und Suchtpotenzial. Eine Opioidtherapie, wenn überhaupt, sollte nur nach frustraner Nicht-Opioid-Therapie, zeitlich begrenzt (möglichst kürzer als vier Wochen) und nach klaren Richtlinien erfolgen.
Abstract. The therapy of back pain – especially the medication with opioids – can be challenging for the treating physician. Specific back pain can often be diagnosed by imaging and successfully treated by surgery or medication. In contrast, nonspecific back pain can be worsened by inappropriate imaging, questionable surgical indications and uncontrolled drug use. For the therapy of nonspecific back pain, maintaining daily activity and exercise therapy is central. Opioids are effective drugs for short-term use. However, long-term use often leads to opioid-induced hyperalgesia and hormonal dysfunction with decreased quality of life and libido. Furthermore, opioids can lead to abuse and addiction. After an ineffective treatment with non-opioids, opioids may be given for a limited time period (if possible shorter than four weeks) according to international guidelines.
Résumé. La thérapie du mal de dos – en particulier la médication avec des opioïdes – peut être un défi pour le médecin traitant. Les douleurs dorsales spécifiques peuvent souvent être diagnostiquées par imagerie et traitées avec succès par chirurgie ou par médicaments. Par contraste, les douleurs dorsales non spécifiques peuvent être aggravées par une imagerie inappropriée, des indications chirurgicales douteuses et une utilisation incontrôlée des médicaments. Pour le traitement des douleurs dorsales non spécifiques, le maintien de l’activité quotidienne et la thérapie par l’exercice sont essentiels. Les opioïdes sont des médicaments efficaces à court terme. Cependant, l’utilisation à long terme entraîne souvent une hyperalgésie induite par les opioïdes et un dysfonctionnement hormonal avec une diminution de la qualité de vie et de la libido. En outre, les opioïdes peuvent entraîner un abus et une dépendance. Après un traitement inefficace avec des non-opioïdes, les opioïdes peuvent être administrés pendant une période limitée (si possible inférieure à quatre semaines), selon des directives claires.
Bibliografie
The Role of Pain Classification Systems in Pain Management. Crit Care Nurs Clin North Am . 2017; 29 (4):407–418.
.Are Pain Beliefs, Cognitions, and Behaviors Influenced by Race, Ethnicity, and Culture in Patients with Chronic Musculoskeletal Pain: A Systematic Review. Pain Physician . 2018; 21 (6):541–558.
.The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. J Pain . 2014; 15 (3):241–249.
,Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci . 2018; 19 (3):138–152.
.Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. Neurotherapeutics . 2020; 17 (3):846–860.
,A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J . 2008; 8 (1):8–20.
.Characteristics and health care costs in patients with a diagnostic imaging for low back pain in Switzerland. Eur J Health Econ . 2021. doi: 10.1007/s10198-021-01397-8.
.Costs of back pain in Germany. Eur J Pain . 2009; 13 (3):280–286.
.Low back pain: what is the long-term course? A review of studies of general patient populations. Eur Spine J . 2003; 12 (2):149–165.
.Clinical course of non-specific low back pain: a systematic review of prospective cohort studies set in primary care. Eur J Pain . 2013; 17 (1):5–15.
.Low back pain. N Engl J Med . 2001; 344 (5):363–370.
.Bundesärztekammer (BÄK) . A.d.W.M.F.A., Kassenärztliche Bundesvereinigung (KBV), Nationale VersorgungsLeitlinie Kreuzschmerz – Leitlinienreport, 2. Auflage. Version 1. 2017; letzter Zugriff: 04.09.2021.Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am . 1990; 72 (3):403–408.
.Imaging strategies for low-back pain: systematic review and meta-analysis. Lancet . 2009; 373 (9662):463–472.
.Association of early imaging for back pain with clinical outcomes in older adults. JAMA . 2015; 313 (11):1143–1153.
,Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines. Eur J Pain . 2021; 25 (2):275–295.
,Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians. Ann Intern Med . 2011; 154 (3):181–189.
,Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med . 1994; 331 (2):69–73.
.The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study: baseline data. Spine (Phila Pa 1976) . 2001; 26 (10):1158–1166.
.Radiography of the lumbar spine in primary care patients with low back pain: randomised controlled trial. BMJ . 2001; 322 (7283):400–405.
.Red flags to screen for vertebral fracture in patients presenting with low-back pain. Cochrane Database Syst Rev. 2013(1):Cd00 8643.
,Red flags to screen for malignancy and fracture in patients with low back pain: systematic review. BMJ . 2013; 347 :f7095.
,Red flags to screen for malignancy in patients with low-back pain. Cochrane Database Syst Rev . 2013(2): Cd00 8686.
.The test of Lasègue: systematic review of the accuracy in diagnosing herniated discs. Spine (Phila Pa 1976) . 2000; 25 (9):1140–1147.
.Content validity of manual spinal palpatory exams – A systematic review. BMC Complement Altern Med . 2003; 3 :1.
,Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain. Cochrane Database Syst Rev . 2010(2):Cd007431.
,Symptoms and signs of sciatica and their relation to the localization of the lumbar disc herniation. Spine (Phila Pa 1976) . 1985; 10 (1):88–92.
.Study on dermatomes by means of selective lumbar spinal nerve block. Spine (Phila Pa 1976) . 1993; 18 (13):1782–1786.
.Measuring muscle strength. J Neurol . 1984; 231 (4):200–203.
.Management of acute aortic dissections. Ann Thorac Surg . 1970; 10 (3):237–247.
.Type A Aortic Dissection – Experience Over 5 Decades: JACC Historical Breakthroughs in Perspective. J Am Coll Cardiol . 2020; 76 (14):1703–1713.
,Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res . 2011: 20 (10):1727–1236.
,German Value Set for the EQ-5D-5L. Pharmacoeconomics . 2018; 36 (6):663–674.
.Why are there different versions of the Oswestry Disability Index? J Neurosurg Spine . 2014; 20 (1):83–86.
.The Oswestry low back pain disability questionnaire. Physiotherapy . 1980; 66 (8):271–273.
.A Systematic Review of Cross-cultural Adaptation of the Oswestry Disability Index. Spine (Phila Pa 1976) . 2016; 41 (24):e1470–e1478.
,Validation of the German version of the STarT-Back Tool (STarT-G): a cohort study with patients from primary care practices. BMC Musculoskelet Disord . 2015; 16 :346.
,Psychologically informed interventions for low back pain: an update for physical therapists. Phys Ther . 2011; 91 (5):765–776.
.Comorbid subjective health complaints in low back pain. Spine (Phila Pa 1976) . 2006; 31 (13):1491–1495.
.Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds. Spine (Phila Pa 1976) . 2004; 29 (13):1483–1491; discussion 1492.
,Is low back pain part of a general health pattern or is it a separate and distinctive entity? A critical literature review of comorbidity with low back pain. J Manipulative Physiol Ther . 2003; 26 (4):243–252.
.Comorbidity of low back pain: representative outcomes of a national health study in the Federal Republic of Germany. Eur J Pain . 2007; 11 (4):387–397.
.Is alcohol intake associated with low back pain? A systematic review of observational studies. Man Ther . 2013: 18 (3):183–190.
.The association between obesity and low back pain: a meta-analysis. Am J Epidemiol . 2010; 171 (2):135–154.
,The association between smoking and low back pain: a meta-analysis. Am J Med . 2010; 123 (1):87.e7–35.
.[Physical movement – is it good for the back? Nationwide representative study on different effects of physical activity at the workplace and in leisure time]. Orthopade . 2009; 38 (10):943–955.
.Changes after multidisciplinary pain treatment in patient pain beliefs and coping are associated with concurrent changes in patient functioning. Pain . 2007; 131 (1–2):38–47.
.Low Back Pain-Related Disability Is Associated with Pain-Related Beliefs Across Divergent Non-English-Speaking Populations: Systematic Review and Meta-Analysis. Pain Med . 2021.
.Differences in Pain Coping Between Black and White Americans: A Meta-Analysis. J Pain . 2016; 17 (6):642–653.
.Comparison of the repercussions of cLBP in four French-speaking countries. Ann Phys Rehabil Med . 2009; 52 (10):717–728.
,Racial differences in osteoarthritis pain and function: potential explanatory factors. Osteoarthritis Cartilage . 2010; 18 (2):160–167.
.Evaluating chronic pain interventions in recent refugees and immigrant populations: A systematic review. Patient Educ Couns . 2021.
.Cross-cultural adaptation of the Neck Pain and Disability Scale: a methodological systematic review. Spine J . 2019; 19 (6):1057–1066.
,Opioids After Surgery in the United States Versus the Rest of the World: The International Patterns of Opioid Prescribing (iPOP) Multicenter Study. Ann Surg . 2020; 272 (6):879–886.
,[Recommendations of the second update of the LONTS guidelines: Long-term opioid therapy for chronic noncancer pain]. Schmerz . 2020; 34 (3): 204–244.
,Physical conditioning as part of a return to work strategy to reduce sickness absence for workers with back pain. Cochrane Database Syst Rev . 2013 (8):Cd001822.
.Effectiveness of exercise on work disability in patients with non-acute non-specific low back pain: Systematic review and meta-analysis of randomised controlled trials. J Rehabil Med . 2010; 42 (3): 193–205.
.Exercises for prevention of recurrences of low-back pain. Cochrane Database Syst Rev . 2010(1):Cd006555.
.High-quality controlled trials on preventing episodes of back problems: systematic literature review in working-age adults. Spine J . 2009; 9 (2):147–168.
.SPINE20 A global advocacy group promoting evidence-based spine care of value. Eur Spine J . 2021; 30 (8):2091–2101.
,What are patient beliefs and perceptions about exercise for nonspecific chronic low back pain? A systematic review of qualitative studies. Clin J Pain . 2014; 30 (11):995–1005.
.Health coaching for low back pain: a systematic review of the literature. Int J Clin Pract . 2014; 68 (8):950–962.
.A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J . 2011; 20 (1):19–39.
,Advice for the management of low back pain: a systematic review of randomised controlled trials. Man Ther . 2007; 12 (4):310–327.
.Desire to Receive More Pain Treatment – A Relevant Patient-Reported Outcome Measure to Assess Quality of Post-Operative Pain Management? Results From 79,996 Patients Enrolled in the Pain Registry QUIPS from 2016 to 2019. J Pain. 2021;22(6): 730–738.
,Non-steroidal anti-inflammatory drugs for acute low back pain. Cochrane Database Syst Rev. 2020;4(4): Cd013581.
.Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev . 2008(1):Cd000396.
.Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database Syst Rev . 2016; 2 (2):Cd012087.
.AHRQ Comparative Effectiveness Reviews, in Treatments for Acute Pain: A Systematic Review. Agency for Healthcare Research and Quality (US); Rockville (MD): 2020.
,A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. Eur Spine J . 2011; 20 (1):40–50.
,Drug therapy for the treatment of chronic nonspecific low back pain: systematic review and meta-analysis. Pain Physician . 2013; 16 (6):E685–E704.
.Nonsurgical treatments for patients with radicular pain from lumbosacral disc herniation. Spine J . 2019; 19 (9):1478–1489.
,Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview. Eur Spine J . 2018; 27 (11): 2791–2803.
,Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med . 2017; 166 (7):514–530.
,Guideline summary review: an evidence-based clinical guideline for the diagnosis and treatment of low back pain. Spine J . 2020; 20 (7):998–1024.
,Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. Cochrane Database Syst Rev . 2015(10):Cd010902.
.Non-steroidal anti-inflammatory drugs for sciatica. Cochrane Database Syst Rev . 2016; 10 (10):Cd012382.
,Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol . 2020; 180 :114147.
.Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies. Clin Cardiol . 2016; 39 (2):111–118.
.Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. Gut . 2006; 55 (12):1731–1738.
,Cardiovascular and Bleeding Risks Associated With Nonsteroidal Anti-Inflammatory Drugs After Myocardial Infarction. J Am Coll Cardiol . 2020; 76 (5):518–529.
,Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: a meta-analysis. J Clin Pharm Ther . 2017; 42 (1):27–38.
.Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial. Eur Heart J . 2017; 38 (44):3282–3292.
,Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2017;6 (6):Cd012095.
.Effects of selective COX-2 inhibition on prostanoids and platelet physiology in young healthy volunteers. J Thromb Haemost. 2007;5 (12):2376–2385.
,Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. J Clin Pharmacol. 2000;40(2):124–132.
,Single dose dipyrone (metamizole) for acute postoperative pain in adults. Cochrane Database Syst Rev. 2016;4(4):Cd011421.
.Paracetamol for low back pain. Cochrane Database Syst Rev. 2016(6): Cd012230.
,Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ . 2015. 350 :h1225.
,Oral paracetamol (acetaminophen) for cancer pain. Cochrane Database Syst Rev. 2017;7(7):Cd012637.
,Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database Syst Rev . 2016; 12 (12):Cd012227.
,Over-the-Counter Relief From Pains and Pleasures Alike: Acetaminophen Blunts Evaluation Sensitivity to Both Negative and Positive Stimuli. Psychol Sci . 2015; 26 (6):750–758.
.Effects of acetaminophen on risk taking. Soc Cogn Affect Neurosci . 2020; 15 (7):725–732.
.Opioid-induced Hyperalgesia in Patients with Chronic Pain: A Systematic Review of Published Cases. Clin J Pain . 2021.
.Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review. Am J Ther . 2019; 26 (3):e397–e405.
.Adverse Outcomes Associated with Prescription Opioids for Acute Low Back Pain: A Systematic Review and Meta-Analysis. Pain Physician . 2019; 22 (2):119–138.
,Opioids compared to placebo or other treatments for chronic low-back pain. Cochrane Database Syst Rev . 2013(8):Cd004959.
.Efficacy, Tolerability, and Dose-Dependent Effects of Opioid Analgesics for Low Back Pain: A Systematic Review and Meta-analysis. JAMA Intern Med . 2016; 176 (7):958–968.
.[Opioids in chronic low back pain. A systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least 4 weeks duration]. Schmerz . 2015; 29 (1):60–72.
.Tramadol for neuropathic pain in adults. Cochrane Database Syst Rev . 2017; 6 (6):Cd003726.
.Morphine for chronic neuropathic pain in adults. Cochrane Database Syst Rev . 2017; 5 (5):Cd011669.
,Hydromorphone for neuropathic pain in adults. Cochrane Database Syst Rev . 2016(5):Cd011604.
,Oxycodone for neuropathic pain in adults. Cochrane Database Syst Rev . 2016; 7 (7):Cd010692.
.Fentanyl for neuropathic pain in adults Cochrane Database Syst Rev . 2016; 10 (10):Cd011605.
.Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from Bayesian Network Meta-Analysis. Pain Physician . 2021; 24 (1):73–82.
.PEER systematic review of randomized controlled trials: Management of chronic low back pain in primary care. Can Fam Physician . 2021; 67 (1): e20–e30.
,Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database Syst Rev . 2017; 11 (11):Cd010323.
,Opioids for cancer pain – an overview of Cochrane reviews. Cochrane Database Syst Rev . 2017; 7 (7):Cd012592.
.Nortriptyline for neuropathic pain in adults. Cochrane Database Syst Rev . 2015; 1 (1):Cd011209.
.Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis. BMJ . 2021; m4825.
,Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med . 2007; 147 (7):505–514.
.Antidepressants for non-specific low back pain. Cochrane Database Syst Rev . 2008(1):Cd001703.
.Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev . 2019; 1 (1):Cd007076.
.Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev . 2017; 6 (6):Cd007938.
,Muscle relaxants for non-specific low back pain. Cochrane Database Syst Rev . 2003(2):Cd004252.
.Efficacy and tolerability of muscle relaxants for low back pain: Systematic review and meta-analysis. Eur J Pain . 2017; 21 (2): 228–237.
.Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis. BMJ . 2021; 374 :n1446.
,Acupuncture for acute low back pain: a systematic review. Clin J Pain . 2013; 29 (2):172–185.
.Acupuncture for acute low back pain: a systematic review and meta-analysis. Ann Palliat Med . 2021; 10 (4): 3924–3936.
,Efficacy and safety of acupuncture in treating acute low back pain: a systematic review and bayesian network meta-analysis. Ann Palliat Med . 2021; 10 (6): 6156–6167.
,AHRQ Comparative Effectiveness Reviews, in Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review . Agency for Healthcare Research and Quality (US); Rockville (MD): 2018.
,Acupuncture for chronic nonspecific low back pain. Cochrane Database Syst Rev . 2020; 12 (12):Cd013814.
.Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med . 2012; 172 (19):1444–1453.
,A systematic review on the effectiveness of complementary and alternative medicine for chronic non-specific low-back pain. Eur Spine J . 2010; 19 (8):1213–1228.
,Can Acupuncture Improve Chronic Spinal Pain? A Systematic Review and Meta-Analysis. Global Spine J . 2021; 11 (8):1248–1265.
,Individual patient education for low back pain. Cochrane Database Syst Rev . 2008 (1):Cd004057.
,Effect of Primary Care-Based Education on Reassurance in Patients With Acute Low Back Pain: Systematic Review and Meta-analysis. JAMA Intern Med . 2015; 175 (5): 733–743.
.Bed rest for acute low-back pain and sciatica. Cochrane Database Syst Rev . 2004(4):Cd001254.
.Advice to rest in bed versus advice to stay active for acute low-back pain and sciatica. Cochrane Database Syst Rev . 2010(6):Cd007612.
.Interventions available over the counter and advice for acute low back pain: systematic review and meta-analysis. J Pain . 2014; 15 (1):2–15.
.Exercise therapy for treatment of non-specific low back pain. Cochrane Database Syst Rev . 2005(3):Cd000335.
.Motor control exercise for acute non-specific low back pain. Cochrane Database Syst Rev . 2016; 2 :Cd012085.
,Pilates for Low Back Pain: Complete Republication of a Cochrane Review. Spine (Phila Pa 1976) . 2016; 41 (12):1013–1021.
,Exercise for improving outcomes after osteoporotic vertebral fracture. Cochrane Database Syst Rev . 2019; 7 (7):Cd008618.
,[Segmental stabilization in low back pain: a systematic review]. Sportverletz Sportschaden . 2010; 24 (1):17–25.
.Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev . 2017; 4 (4):Cd011279.
.Exercise therapy for chronic low back pain. Cochrane Database Syst Rev . 2021; 9 (9):Cd009790.
.Motor control exercise for chronic non-specific low-back pain. Cochrane Database Syst Rev . 2016(1):Cd012004.
,Yoga treatment for chronic non-specific low back pain. Cochrane Database Syst Rev . 2017:1(1):Cd010671.
.Physiotherapy-provided operant conditioning in the management of low back pain disability: A systematic review. Physiother Res Int . 2011; 16 (1):4–19.
.A systematic review and meta-analysis of yoga for low back pain. Clin J Pain . 2013; 29 (5):450–460.
.Yoga for functional ability, pain and psychosocial outcomes in musculoskeletal conditions: a systematic review and meta-analysis. Musculoskeletal Care . 2013; 11 (4):203–217.
.An update of stabilisation exercises for low back pain: a systematic review with meta-analysis. BMC Musculoskelet Disord . 2014; 15 :416.
.Walking exercise for chronic musculoskeletal pain: systematic review and meta-analysis. Arch Phys Med Rehabil . 2015; 96 (4):724–734.e3.
,Manipulation and mobilisation for neck pain contrasted against an inactive control or another active treatment. Cochrane Database Syst Rev . 2015(9):Cd004249.
,Association of Spinal Manipulative Therapy With Clinical Benefit and Harm for Acute Low Back Pain: Systematic Review and Meta-analysis. JAMA . 2017; 317 (14):1451–1460.
,Osteopathic manipulative treatment for nonspecific low back pain: a systematic review and meta-analysis. BMC Musculoskelet Disord . 2014; 15 :286.
.Muscle energy technique for non-specific low-back pain. Cochrane Database Syst Rev . 2015(2):Cd009852.
.Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials. BMJ . 2019: 364 :l689.
.Osteopathic intervention in chronic non-specific low back pain: a systematic review. BMC Musculoskelet Disord . 2013; 14 :129.
.Massage for low-back pain. Cochrane Database Syst Rev . 2015 (9):Cd001929.
.A systematic review and meta-analysis of efficacy, cost-effectiveness, and safety of selected complementary and alternative medicine for neck and low-back pain. Evid Based Complement Alternat Med . 2012:953139.
,Relaxation Techniques in Low Back Pain Patients: A Randomized Controlled Trial. J Long Term Eff Med Implants . 2021; 31 (2):39–44.
,EMG biofeedback training, relaxation training, and placebo for the relief of chronic back pain. Percept Mot Skills . 1986; 63 (3):1023–1036.
.Behavioural treatment for chronic low-back pain. Cochrane Database Syst Rev . 2010(7):Cd002014.
,Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev . 2017; 9 (9):Cd011976.
.Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain. Cochrane Database Syst Rev . 2008; 2008 (4):Cd003008.
.Transcutaneous electrical nerve stimulation (TENS) for chronic neck pain. Cochrane Database Syst Rev . 2019; 12 (12):Cd011927.
.The efficacy, safety, effectiveness, and cost-effectiveness of ultrasound and shock wave therapies for low back pain: a systematic review. Spine J . 2011; 11 (10):966–977.
.The Effectiveness of Non-Pharmaceutical Interventions Upon Pregnancy-Related Low Back Pain: A Systematic Review and Meta-Analysis. Cureus . 2021; 13(1):e13011.
.Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database Syst Rev . 2020; 8 (8):Cd007407.
.Cognitive-behavioural treatment for subacute and chronic neck pain. Cochrane Database Syst Rev . 2015(5);Cd010664.
,The efficacy of targeted interventions for modifiable psychosocial risk factors of persistent nonspecific low back pain – a systematic review. Man Ther . 2012; 17 (5): 385–401.
.Interventions focusing on psychosocial risk factors for patients with non-chronic low back pain in primary care – a systematic review. Fam Pract . 2014; 31 (4):379–388.
,Graded activity and graded exposure for persistent nonspecific low back pain: a systematic review. Phys Ther . 2010; 90 (6):860–879.
.A Cochrane review of superficial heat or cold for low back pain. Spine (Phila Pa 1976) . 2006; 31 (9):998–1006.
.Treating acute low back pain with continuous low-level heat wrap therapy and/or exercise: a randomized controlled trial. Spine J . 2005; 5 (4):395–403.
,Interventions for preventing and treating low-back and pelvic pain during pregnancy. Cochrane Database Syst Rev . 2015; 2015 (9):Cd001139.
.The effect of lifting during work on low back pain: a health impact assessment based on a meta-analysis. Occup Environ Med . 2014; 71 (12):871–877.
,Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol . 2011; 25 (2):173–183.
.Whole-body vibration and the risk of low back pain and sciatica: a systematic review and meta-analysis. Int Arch Occup Environ Health . 2015; 88 (4):403–418.
.[Patients with low back pain. Psychosocial work-related factors and return to work – a literature review]. Orthopade . 2010; 39 (9):866–873.
.Identifying potential moderators for response to treatment in low back pain: A systematic review. Physiotherapy . 2015; 101 (3): 243–251.
.Will this patient develop persistent disabling low back pain? JAMA . 2010; 303 (13):1295–1302.
.Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol . 2007; 21 (3):403–425.
.Fear-avoidance beliefs – a moderator of treatment efficacy in patients with low back pain: a systematic review. Spine J . 2014; 14 (11):2658–2678.
.Changes in pain-related beliefs, coping, and catastrophizing predict changes in pain intensity, pain interference, and psychological functioning in individuals with myotonic muscular dystrophy and facioscapulohumeral dystrophy. Clin J Pain . 2012; 28 (1):47–54.
.Psychosocial risk factors for chronic low back pain in primary care – a systematic review. Fam Pract . 2011; 28 (1):12–21.
,Individual recovery expectations and prognosis of outcomes in non-specific low back pain: prognostic factor review. Cochrane Database Syst Rev . 2019; 2019 (11):CD011284.
.The association between health care professional attitudes and beliefs and the attitudes and beliefs, clinical management, and outcomes of patients with low back pain: a systematic review. Eur J Pain . 2012; 16 (1): 3–17.
.Milnacipran for neuropathic pain in adults. Cochrane Database Syst Rev . 2015 (7):Cd011789.
.Spinal manipulative therapy for acute low-back pain. Cochrane Database Syst Rev . 2012(9):Cd008880.
.Combined chiropractic interventions for low-back pain. Cochrane Database Syst Rev . 2010(4):Cd005427.
.Superficial heat or cold for low back pain. Cochrane Database Syst Rev . 2006(1):Cd004750.
.