Skip to main content
Review

Physicochemical properties and health benefits of pistachio nuts

A comprehensive review

Published Online:https://doi.org/10.1024/0300-9831/a000529

Abstract. The genus of Pistacia plant systematically fits into the family of Anacardiaceae. Pistachios contain protein, carbohydrate, dietary fibers, fat, folic acid, vitamin K, magnesium and potassium, gama-tocopherols, phytochemicals, and polyphenols. Collectively, these constituents have been shown to possess antioxidant and anti-inflammatory functions to improve overall health when consumed as a healthy diet. We searched the following keywords within the literature databases: pistachio, heart disorders, lipids, weight, antioxidants, and allergy. Further searching theses keywords, we have found 50 articles in PubMed, 40 articles in ISI web of knowledge and 30 articles in Google Scholar. We have selected 100 articles, among them 80 articles were used as the references of this review. In the current article, we have discussed the most recent data published regarding the regulatory effects of pistachios on several clinical states such as heart related disorders, hyperlipidemia, hypertension, vascular stiffness and endothelial and gut functions, weight management, glucose metabolism, kidney function and finally allergies.

References

  • 1 Karimi, H.R., Kafkas, S., Zamani, Z., Ebadi, A., & Moghadam, M.R.F. (2009) Genetic relationships among Pistacia species using AFLP markers. Plant Syst Evol. 279, 21–28. First citation in articleCrossrefGoogle Scholar

  • 2 Hormaza, J., & Wünsch, A. (2007) Pistachio. In C. KoleEd., Fruits and nuts (Vol. 4 pp. 243–251). New York: Springer. First citation in articleGoogle Scholar

  • 3 Salas-Salvadó, J., Casas-Agustench, P., & Salas-Huetos, A. (2011) Cultural and historical aspects of Mediterranean nuts with emphasis on their attributed healthy and nutritional properties. Nutr Metab Cardiovasc Dis. 21, S1–S6. First citation in articleCrossref MedlineGoogle Scholar

  • 4 King, J.C., Blumberg, J., Ingwersen, L., Jenab, M., & Tucker, K.L. (2008) Tree nuts and peanuts as components of a healthy diet. J Nutr. 138, 1736S–1740S. First citation in articleCrossref MedlineGoogle Scholar

  • 5 Lloyd-Jones, D.M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L.J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., & Tomaselli, G.F. (2010) Defining and setting national goals for cardiovascular health promotion and disease reduction. Circulation. 121, 586–613. First citation in articleCrossref MedlineGoogle Scholar

  • 6 Committee, D.G.A. (2010) Report of the dietary guidelines advisory committee on the dietary guidelines for Americans, 2010, to the Secretary of Agriculture and the Secretary of Health and Human Services. Agr Res Serv. First citation in articleGoogle Scholar

  • 7 Shahrabadi, E., Esmaeili Nadimi, A., Jalalli, N., Shahrabadi, A., Shahriyari, A., & Asadollahi, N. (2014) The effect of pistachios on human health: A review study. J Occup Health Epidemiol. First citation in articleGoogle Scholar

  • 8 Mahmoodabadi, S. K., Panahi, B., Agharahimi, J., & Salajegheh, F. (2012-04-01). Determination of Compounds Existing in Fruits of Three Pistachio (Pistacia vera L.) Cultivars in Kerman Province. J Biol Environ Sci. 6, 81–86. First citation in articleGoogle Scholar

  • 9 Hansson, G.K. (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352, 1685–1695. First citation in articleCrossref MedlineGoogle Scholar

  • 10 Nadimi, A.E., Ahmadi, J., & Mehrabian, M. (2008) Peripheral eosinophil count and allergy in patients with coronary artery disease. Acta Med Indones. 40, 74–77. First citation in articleMedlineGoogle Scholar

  • 11 Esmaeili, N., Nough, H., & Ahmady, J. (2004) Role of C-reactive Protein and Leukocyte Count in Prediction of Cardiac Events in Patients with Unstable Angina. J Zanjan Univ Med Sci. 12, 29–35. First citation in articleGoogle Scholar

  • 12 Kris-Etherton, P.M., Yu-Poth, S., Sabaté, J., Ratcliffe, H.E., Zhao, G., & Etherton, T.D. (1999) Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am J Clin Nutr. 70, 504s–511s. First citation in articleCrossref MedlineGoogle Scholar

  • 13 Mukuddem-Petersen, J., Oosthuizen, W., & Jerling, J.C. (2005) A systematic review of the effects of nuts on blood lipid profiles in humans. J Nutr. 135, 2082–2089. First citation in articleCrossref MedlineGoogle Scholar

  • 14 Kushi, L.H., Folsom, A.R., Prineas, R.J., Mink, P.J., Wu, Y., & Bostick, R.M. (1996) Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med. 334, 1156–1162. First citation in articleCrossref MedlineGoogle Scholar

  • 15 Albert, C.M., Gaziano, J.M., Willett, W.C., & Manson, J.E. (2002) Nut consumption and decreased risk of sudden cardiac death in the Physicians’ Health Study. Arch Intern Med. 162, 1382–1387. First citation in articleCrossref MedlineGoogle Scholar

  • 16 Hu, F.B., Stampfer, M.J., Manson, J.E., Rimm, E.B., Colditz, G.A., Rosner, B.A., Speizer, F.E., Hennekens, C.H., & Willett, W.C. (1998) Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ. 317, 1341–1345. First citation in articleCrossref MedlineGoogle Scholar

  • 17 West, S.G., Gebauer, S.K., Kay, C.D., Bagshaw, D.M., Savastano, D.M., Diefenbach, C., & Kris-Etherton, P.M. (2012) Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia Novelty and Significance. Hypertension. 60, 58–63. First citation in articleCrossref MedlineGoogle Scholar

  • 18 Gebauer, S.K., West, S.G., Kay, C.D., Alaupovic, P., Bagshaw, D., & Kris-Etherton, P.M. (2008) Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study. Am J Clin Nutr. 88, 651–659. First citation in articleCrossref MedlineGoogle Scholar

  • 19 Kasliwal, R.R., Bansal, M., Mehrotra, R., Yeptho, K.P., & Trehan, N. (2015) Effect of pistachio nut consumption on endothelial function and arterial stiffness. Nutrition. 31, 678–685. First citation in articleCrossref MedlineGoogle Scholar

  • 20 Sauder, K.A., McCrea, C.E., Ulbrecht, J.S., Kris-Etherton, P.M., & West, S.G. (2014) Pistachio nut consumption modifies systemic hemodynamics, increases heart rate variability, and reduces ambulatory blood pressure in well-controlled type 2 diabetes: a randomized trial. J Am Heart Assoc. 3(4), e000873. First citation in articleCrossref MedlineGoogle Scholar

  • 21 Sabate, J., & Wien, M. (2010) Nuts, blood lipids and cardiovascular disease. Asia Pac J Clin Nutr. 19, 131–136. First citation in articleMedlineGoogle Scholar

  • 22 Sari, I., Baltaci, Y., Bagci, C., Davutoglu, V., Erel, O., Celik, H., Ozer, O., Aksoy, N., & Aksoy, M. (2010) Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition. 26, 399–404. First citation in articleCrossref MedlineGoogle Scholar

  • 23 Kocyigit, A., Koylu, A., & Keles, H. (2006) Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutr Metab Cardiovasc Dis. 16, 202–209. First citation in articleCrossref MedlineGoogle Scholar

  • 24 Sheridan, M.J., Cooper, J.N., Erario, M., & Cheifetz, C.E. (2007) Pistachio nut consumption and serum lipid levels. J Am Coll Nutr. 26, 141–148. First citation in articleCrossref MedlineGoogle Scholar

  • 25 Edwards, K., Kwaw, I., Matud, J., & Kurtz, I. (1999) Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr. 18, 229–232. First citation in articleCrossref MedlineGoogle Scholar

  • 26 Kay, C.D., Gebauer, S.K., West, S.G., & Kris-Etherton, P.M. (2010) Pistachios increase serum antioxidants and lower serum oxidized-LDL in hypercholesterolemic adults. J Nutr. 140, 1093–1098. First citation in articleCrossref MedlineGoogle Scholar

  • 27 Li, Z., Song, R., Nguyen, C., Zerlin, A., Karp, H., Naowamondhol, K., Thames, G., Gao, K., Li, L., & Tseng, C.-H. (2010) Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program. J Am Coll Nutr. 29, 198–203. First citation in articleCrossref MedlineGoogle Scholar

  • 28 Aldemir, M., Okulu, E., Neselioglu, S., Erel, O., & Kayigil, O. (2011) Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int J Impot Res. 23, 32–38. First citation in articleCrossref MedlineGoogle Scholar

  • 29 Baer, D.J., Gebauer, S.K., & Novotny, J.A. (2012) Measured energy value of pistachios in the human diet. Br J Nutr. 107, 120–125. First citation in articleCrossref MedlineGoogle Scholar

  • 30 Gu, L., Kelm, M.A., Hammerstone, J.F., Beecher, G., Holden, J., Haytowitz, D., Gebhardt, S., & Prior, R.L. (2004) Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr. 134, 613–617. First citation in articleCrossref MedlineGoogle Scholar

  • 31 Wu, X., Beecher, G.R., Holden, J.M., Haytowitz, D.B., Gebhardt, S.E., & Prior, R.L. (2004) Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 52, 4026–4037. First citation in articleCrossref MedlineGoogle Scholar

  • 32 Gentile, C., Tesoriere, L., Butera, D., Fazzari, M., Monastero, M., Allegra, M., & Livrea, M.A. (2007) Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components. J Agric Food Chem. 55, 643–648. First citation in articleCrossref MedlineGoogle Scholar

  • 33 Gulati, S., Misra, A., Pandey, R.M., Bhatt, S.P., & Saluja, S. (2014) Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a 24-wk, randomized control trial. Nutrition. 30, 192–197. First citation in articleCrossref MedlineGoogle Scholar

  • 34 Gentile, C., Perrone, A., Attanzio, A., Tesoriere, L., & Livrea, M.A. (2015) Sicilian pistachio (Pistacia vera L.) nut inhibits expression and release of inflammatory mediators and reverts the increase of paracellular permeability in IL-1beta-exposed human intestinal epithelial cells. Eur J Nutr. 54, 811–821. First citation in articleCrossref MedlineGoogle Scholar

  • 35 Remila, S., Atmani-Kilani, D., Delemasure, S., Connat, J.-L., Azib, L., Richard, T., & Atmani, D. (2015) Antioxidant, cytoprotective, anti-inflammatory and anticancer activities of Pistacia lentiscus (Anacardiaceae) leaf and fruit extracts. Eur J Integ Med. 7, 274–286. First citation in articleCrossrefGoogle Scholar

  • 36 Dellai, A., Souissi, H., Borgi, W., Bouraoui, A., & Chouchane, N. (2013) Antiinflammatory and antiulcerogenic activities of Pistacia lentiscus L. leaves extracts. Ind Crops Prod. 49, 879–882. First citation in articleCrossrefGoogle Scholar

  • 37 Sauder, K.A., McCrea, C.E., Ulbrecht, J.S., Kris-Etherton, P.M., & West, S.G. (2015) Effects of pistachios on the lipid/lipoprotein profile, glycemic control, inflammation, and endothelial function in type 2 diabetes: A randomized trial. Metabolism. 64, 1521–1529. First citation in articleCrossref MedlineGoogle Scholar

  • 38 Dreher, M.L. (2012) Pistachio nuts: composition and potential health benefits. Nutr Rev. 70, 234–240. First citation in articleCrossref MedlineGoogle Scholar

  • 39 Ukhanova, M., Wang, X., Baer, D.J., Novotny, J.A., Fredborg, M., & Mai, V. (2014) Effects of almond and pistachio consumption on gut microbiota composition in a randomised cross-over human feeding study. Br J Nutr. 111, 2146–2152. First citation in articleCrossref MedlineGoogle Scholar

  • 40 Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V.K., Srivastava, T.P., Taylor, T.D., Noguchi, H., Mori, H., Ogura, Y., Ehrlich, D.S., Itoh, K., Takagi, T., Sakaki, Y., Hayashi, T., & Hattori, M. (2007) Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res. 14, 169–181. First citation in articleCrossref MedlineGoogle Scholar

  • 41 Akbari-Alavijeh, S., Soleimanian-Zad, S., Sheikh-Zeinoddin, M., & Hashmi, S. (2018) Pistachio hull water-soluble polysaccharides as a novel prebiotic agent. Int J Biol Macromol. 107, 8080–816. First citation in articleCrossrefGoogle Scholar

  • 42 Hernandez-Alonso, P., Canueto, D., Giardina, S., Salas-Salvado, J., Canellas, N., Correig, X., & Bullo, M. (2017) Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects. J Nutr Biochem. 45, 48–53. First citation in articleCrossref MedlineGoogle Scholar

  • 43 Mattes, R.D., Kris-Etherton, P.M., & Foster, G.D. (2008) Impact of peanuts and tree nuts on body weight and healthy weight loss in adults. J Nutr. 138, 1741S–1745S. First citation in articleCrossref MedlineGoogle Scholar

  • 44 Mozaffarian, D., Hao, T., Rimm, E.B., Willett, W.C., & Hu, F.B. (2011) Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med. 2011, 2392–2404. First citation in articleCrossrefGoogle Scholar

  • 45 Mattes, R.D., & Dreher, M.L. (2010) Nuts and healthy body weight maintenance mechanisms. Asia Pac J Clin Nutr. 19, 137–141. First citation in articleMedlineGoogle Scholar

  • 46 Ribeiro, P.V.M., Silva, A., Almeida, A.P., Hermsdorff, H.H., & Alfenas, R.C (2017) Effect of chronic consumption of pistachios (Pistacia vera L.) on glucose metabolism in pre-diabetics and type 2 diabetics: A systematic review. Crit Rev Food Sci Nutr. 1–9. First citation in articleCrossref MedlineGoogle Scholar

  • 47 Hernandez-Alonso, P., Giardina, S., Salas-Salvado, J., Arcelin, P., & Bullo, M. (2017) Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects. Eur J Nutr. 56, 2181–2191. First citation in articleCrossref MedlineGoogle Scholar

  • 48 Mehenni, C., Atmani-Kilani, D., Dumarcay, S., Perrin, D., Gerardin, P., & Atmani, D. (2016) Hepatoprotective and antidiabetic effects of Pistacia lentiscus leaf and fruit extracts. J Food Drug Anal. 24, 653–669. First citation in articleCrossref MedlineGoogle Scholar

  • 49 Djerrou, Z., Hamdi-Pacha, Y., Belkhiri, A.M., Djaalab, H., Riachi, F., Serakta, M., Boukeloua, A., & Maameri, Z. (2011) Evaluation of Pistacia lentiscus fatty oil effects on glycemic index, liver functions and kidney functions of New Zealand rabbits. Afr J Tradit Complement Altern Med. 8, 214–219. First citation in articleMedlineGoogle Scholar

  • 50 Ehsani, V., Amirteimoury, M., Taghipour, Z., Shamsizadeh, A., Bazmandegan, G., Rahnama, A., Khajehasani, F., & Fatemi, I. (2017) Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats. Ren Fail. 39, 519–525. First citation in articleCrossref MedlineGoogle Scholar

  • 51 Heidarian, E., Jafari-Dehkordi, E., Valipour, P., Ghatreh-Samani, K., & Ashrafi-Eshkaftaki, L. (2017) Nephroprotective and Anti-Inflammatory Effects of Pistacia atlantica Leaf Hydroethanolic Extract Against Gentamicin-Induced Nephrotoxicity in Rats. J Diet Suppl. 14, 489–502. First citation in articleCrossref MedlineGoogle Scholar

  • 52 Cheraft-Bahloul, N., Husson, C., Ourtioualous, M., Sinaeve, S., Atmani, D., Stevigny, C., Nortier, J.L., & Antoine, M.H. (2017) Protective Effects of Pistacia lentiscus L. fruit extract against calcium oxalate monohydrate induced proximal tubular injury. J Ethnopharmacol. 209, 248–254. First citation in articleCrossref MedlineGoogle Scholar

  • 53 Sampson, H.A., Mendelson, L., & Rosen, J.P. (1992) Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 327, 380–384. First citation in articleCrossref MedlineGoogle Scholar

  • 54 Ewan, P.W. (1996) Clinical study of peanut and nut allergy in 62 consecutive patients: new features and associations. BMJ. 312, 1074–1078. First citation in articleCrossref MedlineGoogle Scholar

  • 55 Sicherer, S.H., Muñoz-Furlong, A., Burks, A.W., & Sampson, H.A. (1999) Prevalence of peanut and tree nut allergy in the US determined by a random digit dial telephone survey. J Allergy Clin Immunol. 103, 559–562. First citation in articleCrossref MedlineGoogle Scholar

  • 56 Hasegawa, M., Inomata, N., Yamazaki, H., Morita, A., Kirino, M., & Ikezawa, Z. (2009) Clinical features of four cases with cashew nut allergy and cross-reactivity between cashew nut and pistachio. Allergol Int. 58, 209–215. First citation in articleCrossref MedlineGoogle Scholar

  • 57 Ahn, K., Bardina, L., Grishina, G., Beyer, K., & Sampson, H. (2009) Identification of two pistachio allergens, Pis v 1 and Pis v 2, belonging to the 2S albumin and 11S globulin family. Clin Exp Allergy. 39, 926–934. First citation in articleCrossref MedlineGoogle Scholar

  • 58 Ayuso, R., Grishina, G., Ahn, K., Bardina, L., Beyer, K., & Sampson, H. (2007) Identification of a MnSOD-like protein as a new major pistachio allergen. J Allergy Clin Immunol. 119, S115. First citation in articleCrossref MedlineGoogle Scholar

  • 59 Willison, L., Tawde, P., Robotham, J., Penney, R., Teuber, S.S., Sathe, S., & Roux, K. (2008) Pistachio vicilin, Pis v 3, is immunoglobulin E‐reactive and cross‐reacts with the homologous cashew allergen, Ana o 1. Clin Exp Allergy. 38, 1229–1238. First citation in articleCrossref MedlineGoogle Scholar

  • 60 Parra, F., Cuevas, M., Lezaun, A., Alonso, M., Beristain, A., & Losada, E. (1993) Pistachio nut hypersensitivity: identification of pistachio nut allergens. Clin Exp Allergy. 23, 996–1001. First citation in articleCrossref MedlineGoogle Scholar

  • 61 Fernandez, C., Fiandor, A., Martinez‐Garate, A., & Quesada, J. (1995) Allergy to pistachio: crossre activity between pistachio nut and other Anacardiaceae. Clin Exp Allergy. 25, 1254–1259. First citation in articleCrossref MedlineGoogle Scholar

  • 62 Liccardi, G., Mistrello, G., Noschese, P., Falagiani, P., D’amato, M., & D’amato, G. (1996) Oral allergy syndrome (OAS) in pollinosis patients after eating pistachio nuts: two cases with two different patterns of onset. Allergy. 51, 919–922. First citation in articleMedlineGoogle Scholar

  • 63 Noorbakhsh, R., Mortazavi, S.A., Sankian, M., Shahidi, F., Tehrani, M., Azad, F.J., Behmanesh, F., & Varasteh, A. (2011) Pistachio allergy-prevalence and in vitro cross-reactivity with other nuts. Allergol Int. 60, 425–432. First citation in articleCrossref MedlineGoogle Scholar

  • 64 Sicherer, S.H., Burks, A.W., & Sampson, H.A. (1998) Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 102, e6. First citation in articleCrossref MedlineGoogle Scholar

  • 65 Moneret-Vautrin, D., Rance, F., Kanny, G., Olsewski, A., Gueant, J., Dutau, G., & Guerin, L. (1998) Food allergy to peanuts in France-evaluation of 142 observations. Clin Exp Allergy. 28, 1113–1119. First citation in articleCrossref MedlineGoogle Scholar

  • 66 Wallowitz, M., Teuber, S., Beyer, K., Sampson, H., Roux, K., Sathe, S., Wang, F., & Robotham, J. (2004) Cross-reactivity of walnut, cashew, and hazelnut legumin proteins in tree nut allergic patients. J Allergy Clin Immunol. 113, S156. First citation in articleCrossrefGoogle Scholar

  • 67 Jansen, A., de Raadt, J., van Toorenenbergen, A.W., & van Wijk, R.G. (1992) Allergy to pistachio nuts. In Ed., Allergy and Asthma Proceedings (Vol. 13 pp. 255–258). OceanSide Publications, Inc.. First citation in articleGoogle Scholar

  • 68 Goetz, D.W., Whisman, B.A., & Goetz, A.D. (2005) Cross-reactivity among edible nuts: double immunodiffusion, crossed immunoelectrophoresis, and human specific IgE serologic surveys. Ann Allergy Asthma Immunol. 95, 45–52. First citation in articleCrossref MedlineGoogle Scholar

  • 69 De Leon, M., Glaspole, I., Drew, A., Rolland, J., O’hehir, R., & Suphioglu, C. (2003) Immunological analysis of allergenic cross‐reactivity between peanut and tree nuts. Clin Exp Allergy. 33, 1273–1280. First citation in articleCrossref MedlineGoogle Scholar

  • 70 Bolling, B.W., McKay, D.L., & Blumberg, J.B. (2010) The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr. 19, 117–123. First citation in articleMedlineGoogle Scholar

  • 71 Bullo, M., Juanola-Falgarona, M., Hernandez-Alonso, P., & Salas-Salvado, J. (2015) Nutrition attributes and health effects of pistachio nuts. Br J Nutr. 113(Suppl 2), S79–93. First citation in articleCrossref MedlineGoogle Scholar

  • 72 Edwards, K., Kwaw, I., Matud, J., & Kurtz, I. (1999) Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr. 18, 229–232. First citation in articleCrossref MedlineGoogle Scholar