This work was funded by Health and Care Research Wales (Grant Number SCS-12-14) and by the Welsh Government through Health and Care Research Wales (grant awarded to The National Centre for Mental Health, No. CA04). The funders had no role in study design, collection, analysis or interpretation of data, writing of the report, or decision to submit the paper for publication. KH and DG are funded by National Institute for Health Research Senior Investigators (KH Emeritus). DG is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. JS is a Health and Care Research Wales Senior Research Leader. The CASCADE partnership receives infrastructure funding from Health and Care Research Wales.