Summary:Background: Lower extremity arterial disease (LEAD) is caused by atherosclerotic plaque in the arterial supply to the lower limbs. The neutrophil to lymphocyte and platelet to lymphocyte ratios (NLR, PLR) are established markers of systemic ...
Successful strategy for the prevention of coronary heart disease (CHD) in particular of atherosclerosis, require a detailed understanding of the underlying mechanism. It is now being recognised that dietary antioxidants, in particular vitamin E, will play ...
Ever since oxidation has been known to be involved in atherogenesis, antioxidants have received considerable attention as potential antiatherogenic agents. The lipid-soluble vitamin E is the main antioxidant carried by lipoproteins. Zinc is a water-...
The purpose of this study was to investigate whether cholesterol plus methionine feeding may be a convenient model to produce atherosclerosis in rats, and also to examine the contribution of oxidative stress to this development. For this reason, lipid ...
Background: The study evaluates the effect of a high supplemental dose of ascorbic acid (AA) on plasma concentrations of total cholesterol (TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions high-density, very-low-density-, and low-...
Abstract. Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory ...
Abstract. Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a ...
Hintergrund: Die Rolle von Chlamydia pneumoniae in der Pathogenese der Atherosklerose wurde bisher fast ausschließlich an Patienten mit koronarer Herzkrankheit untersucht. Die anderen Gefäßprovinzen blieben weitestgehend unberücksichtigt. Ziel der ...
Hintergrund: Das Ziel der Studie bestand in der Längenbestimmung der Übergangszone zwischen dem elastischen und dem muskulären Typ der Nierenarterie.
Patienten und Methoden: 26 Nierenarterien von 13 Erwachsenenobduktionen (Durchschnittsalter 61,6 Jahre, ...
Hintergrund: Es wurde postuliert, dass Adhäsionsmoleküle (AM) in der Entwicklung und im Fortschreiten der menschlichen Atherosklerose involviert sind. Wir untersuchten, ob Prostaglandin (PG) E1 die Spiegel der zirkulierenden AM (ICAM-1, VCAM-1 und E-...
A patient who had no evidence of atherosclerotic disease and had never been hypertensive, presented with symptoms usually associated with gallstone disease. A large intraluminal calcification in the juxtarenal aorta was found to be the probable cause of ...
Background: The goal of our study was to demonstrate the extension of the transitional zone (TZ) between elastic and muscular medial structure in carotid artery tripod.
Patients and methods: A histologic study of 56 probes from 8 carotid artery tripods ...
Hintergrund: Erhöhtes mittleres Erythrozytenvolumen (MCV) ist ein möglicher Risikofaktor für die periphere arterielle Verschlusskrankheit (pAVK). Ziel der vorliegenden Studie war es, zu erheben, ob MCV mit einem bestimmten anatomischen Verteilungsmuster ...
Hintergrund: Der peripheren arteriellen Verschlusskrankheit (AVK) kommt große prognostische Bedeutung als Markererkrankung für die generalisierte Atherothrombose zu; sie ist mit einer hohen Morbidität und Mortalität. Trotz ihrer Häufigkeit und Bedeutung ...
Vor über 30 Jahren klassifizierten Darning und Cutler die Femoralaneurysmen in zwei Typen. Wir zeigen mit diesem Fallbericht, dass eine Ergänzung dieser Klassifikation angebracht erscheint. Isolierte Profundaaneurysmen stellen eine separate Entität dar. ...
Die periphere arterielle Verschlusskrankheit (PAVK) wird von uns Ärzten unterdiagnostiziert und in ihrer prognostischen Bedeutung unterschätzt. Die Krankheit bedroht nicht nur die betroffene Extremität der Patienten, sie ist mit einer hohen Mortalität ...
Hintergrund: Frühere Studien zeigten einen anti-arteriosklerotischen Effekt von PADMA 28, ein pflanzliches Stoffgemisch aus der tibetischen Medizin. Zum Verständnis der Wirkmechanismen wurde der Einfluss von PADMA 28 auf die Blutlipidsenkung, Lipid-...
We report a case of an isolated atherosclerotic true aneurysm of the profunda femoris artery. The aneurysm was surgically ligated. The clinical presentation, diagnostic algorithm and therapeutic options are discussed in the scope of the English-language ...
Hintergrund: Die Bestimmung der Konzentration des Cholesteringehaltes der Haut (SkC) könnte einen zusätzlichen Parameter in der Evaluation des kardiovaskulären Risikos darstellen. Daher untersuchten wir neben der Testgenauigkeit und potentiellen ...
Hintergrund: Diese Studie wurde durchgeführt, um zu überprüfen, ob das C-reaktive Protein (CRP) im Vergleich zu etablierten Risikofaktoren der Arteriosklerose (Geschlecht, Alter, Diabetes mellitus, Hochdruck, Rauchen) besser mit einem Rezidiv nach ...
Hintergrund: Ziel dieser Studie war es, einerseits die Korrelation zwischen dem Schweregrad der koronaren Atherosklerose und der Häufigkeit der peripheren arteriellen Verschlusskrankheit (pAVK) zu untersuchen und andererseits festzustellen, ob sich diese ...
Hintergrund: Atherosklerotisch bedingte Läsionen an den oberen Extremitäten entstehen drei- bis fünfmal häufiger am Abgang der linken Arteria subclavia im Vergleich zur rechten Seite. Das Ziel dieser Studie ist es, die hämodynamischen Kräfte (maximale ...
Hintergrund: Das Vorliegen eines Diabetes mellitus (DM) und einer Niereninsuffizienz (NI) bei Patienten mit einer peripheren arteriellen Verschlusskrankheit (pAVK) prädestiniert für eine obstruktive Arteriopathie, die insbesondere die infrapoplitealen ...
This case report describes the very uncommon event of mummification of the lower limb occurring naturally in a patient with peripheral arterial occlusive disease aggravated by severe reactive aversion and serves as a warning that this can happen in cases ...
Hintergrund: Die endovaskuläre Therapie wird zunehmend zur Behandlung der chronischen atherosklerotischen mesenterialen Verschlusskrankheit verwendet. Ziel dieser Studie war die Evaluation der Offenheitsrate bei Patienten nach perkutaner transluminaler ...
Background: Peripheral artery disease (PAD) affecting the femoropopliteal artery is treated by endovascular interventions [2, 5, 13] increasingly. Aim of the study was to evaluate mid-term efficacy and patency of long stents in the superficial femoral and ...
Background: Atherosclerosis is emerging as an important complication of rheumatoid arthritis (RA), with coronary artery disease being projected as the major cause of mortality in these patients.This study was undertaken to evaluate the presence of ...
The use of contrast-enhanced ultrasound (CEUS) for vascular imaging indications has increased dramatically during the last decade. Ultrasound contrast agents are gas-filled microbubbles that are injected into the bloodstream and serve as strict ...
Background: Multi-detector computed tomography (MDCT) is more and more used for evaluation and quantification of coronary artery calcification, but correlation between the degree of calcification and occurrence of clinical events is also known for other ...
Radiation induced atherosclerosis of the carotid artery is a clinically relevant late complication after head and neck radiotherapy. Improved long-term survival after multimodality therapy in neck malignancies result in an increased risk of carotid artery ...
Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement ...
Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between ...
Abstract. Background: Qualitative change in carotid plaques was prospectively evaluated by Gray Scale Median (GSM) analysis at repeated examinations “in vivo”, in relation to quantitative change in carotid arterial geometry, as assessed by high-resolution ...
Abstract.Background: Pseudoxanthoma elasticum (PXE) is an autosomal recessive inherited multisystem disorder of the connective tissue caused by a loss-of-function mutation of the ABCC6 gene. It can affect the ...
Abstract.Background: The beneficial effect of statin therapy on the progress of atherosclerotic disease has been demonstrated by numerous studies. Vascular strain imaging is an arising method to evaluate arterial ...
Abstract.Background: Genome-wide association studies identified several gene variants associated with peripheral arterial disease (PAD). Among them, rs6584389 A>C was significantly associated with PAD defined by ...
Abstract.Background: The role of vascular calcifications in iliac arteries for predicting global atherosclerotic burden in still unknown. The aim of this study was to investigate whether iliac calcium score (ICS), ...
Abstract.Background: Atherosclerosis is the leading cause of death worldwide. Ischaemic stroke, coronary heart disease (CHD), and peripheral artery disease (PAD) are different forms of atherosclerotic disease. ...
Abstract. Early detection of vascular damage in atherosclerosis and accurate assessment of cardiovascular risk factors are the basis for appropriate treatment strategies in cardiovascular medicine. The current ...
Abstract.Background: The enzyme glyoxalase1 (GLO1) is the main opponent in the degradation of the reactive metabolite methylglyoxal (MG), which by glycation of macromolecules is involved in atherogenesis. Reduced ...
Summary:Background: Radiotherapy for head and neck cancer (HNC) represents a well-known predisposing factor for asymptomatic carotid artery lesions and acute cerebrovascular accidents. Our aim is to provide contemporary estimates on the ...
Summary: This review provides an updated overview of the emerging roles of neopterin derivatives in atherosclerosis. Neopterin, a metabolite of guanosine triphosphate, is produced by interferon-γ-activated macrophages and is expressed at high levels in ...
Summary:Background: Radiation-induced carotid artery disease (RICAD) is an important issue in head and neck cancer (HNC) survivors after radiotherapy (RT). The risk of cerebrovascular disease in these patients is doubled. The aim of this ...
Summary: Drainage of the arterial wall via adventitial lymphatic vessels has been shown to play a pivotal role for vessel wall homeostasis. Also, retrograde cholesterol transport is ensured via this route, but no studies exist to ...
Summary:Background: Peripheral artery disease (PAD) impacts 3–12% of patients worldwide and is characterized by endothelial dysfunction and inflammatory pathways which are also common to venous thromboembolism (VTE), but there is a ...
Summary: The cell’s response to hypoxia depends on stabilization of the hypoxia-inducible factor 1 complex and transactivation of nuclear factor kappa-B (NF-κB). HIF target gene transcription in cells resident to atherosclerotic lesions adjoins a complex ...