Skip to main content
Freie Beiträge

Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS): Wie valide sind die Subtypen?

Published Online:https://doi.org/10.1026/0942-5403.14.4.244

Zusammenfassung. Bereits mit Erscheinen des DSM-IV wurde die Validität der dort benannten Subtypen der ADHS hinterfragt. Hinzu kommt eine abweichende Subgruppenbildung in der ICD-10. Seitdem sind die Subtypen in verschiedenen Zusammenhängen untersucht worden. Dabei festgestellte Unterschiede und Gemeinsamkeiten der Subtypen werden aus sechs Perspektiven (verhaltensbezogen, genetisch, geschlechtsspezifisch, entwicklungsbezogen, neurobiologisch, neuropsychologisch) betrachtet, um Informationen über mögliche notwendige Veränderungen im DSM-V zu erlangen. Die Befunde legen zunächst nahe, sich bei zukünftigen Klassifikationskriterien nicht auf die Verhaltensebene zu beschränken, sondern insbesondere neuropsychologische aber auch neurobiologische Aspekte einzubeziehen. So wird unter Berücksichtigung dieser Ebenen für den bisherigen vorwiegend unaufmerksamen Subtyp eine weitere Differenzierung angedeutet: in eine Gruppe mit verlangsamtem kognitiven Tempo, die eventuell sogar eine eigenständige Störung darstellt, sowie einen vorwiegend unaufmerksamen Subtyp der ADHS, der aber schwache Symptome der Hyperaktivität und Impulsivität aufweist. Des Weiteren deutet sich zwar auf einigen Ebenen ein eigenständiger Subtyp ADHS mit komorbiden Störungen des Sozialverhaltens beziehungsweise einer Hyperkinetischen Störung des Sozialverhaltens an. Jedoch sind Befunde anderer Ebenen noch nicht eindeutig und somit ist weitere Forschung notwendig. Zudem scheinen gesonderte Kriterien für die Geschlechter nicht erforderlich, vielmehr sollte stärker beachtet werden, dass auch Mädchen diese Störung aufweisen können. Abschließend werden Implikationen für zukünftige Klassifikationen und ihre Bedeutung für unterschiedliche Behandlungsverfahren diskutiert.


Attention-Deficit/Hyperactivity Disorder (ADHD): Validity of the subtypes

Abstract. Already with the publication of the DSM-IV the validity of the DSM-IV subtypes of ADHD was questioned. In addition, the ICD-10 describes different guidelines for subtype classification. Ever since the subtypes have been examined in many different ways. To gain further information about necessary alterations of the DSM-V, the differences and points in common found in the subtypes are presented. Six different approaches are considered (behavioral, genetic, gender, developmental, neurobiological, and neuropsychological). The results suggest considering additional aspects beyond behavioral symptom criteria - especially neurobiological and neuropsychological criteria. Thereby a differentiation of the predominantly inattentive subtype is supported: into a) a subgroup with sluggish cognitive tempo, which possibly represents an independent disorder and b) a predominantly inattentive subtype of ADHD, but with slight symptoms of hyperactivity and impulsivity. Furthermore, some approaches imply an independent ADHD aggressive subtype or hyperkinetic conduct disorder. But up to the present the results are not univocal so that additional studies are required. It seems unnecessary to develop special criteria for boys and girls; but it must be taken into consideration more carefully that girls can also have ADHS. Finally, implications for future classification systems of ADHD and their relevance to different treatment approaches are discussed.

Literatur

  • American Psychiatric Association (1994). DSM-IV: Diagnostic and Statistical Manual of Mental Disorder. (4th ed.). Washington: American Psychiatric Press . First citation in articleGoogle Scholar

  • Banaschewski, T. , Brandeis, D. , Heinrich, H. , Albrecht, B. , Brunner, E. , Rothenberger, A. (2003). Association of ADHD and conduct disorder and brain electrical evidence for the existence of adistinct subtype. Journal of Child Psychology and Psychiatry , 43 , 1– 21 . First citation in articleGoogle Scholar

  • Banaschewski, T. , Roessner, V. , Uebel, H. , Rothenberger, A. (2004). Neurobiologie der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS). Kindheit und Entwicklung , 13 , 180– 189 . First citation in articleLinkGoogle Scholar

  • Barkley, R. A. (1995). A closer look at the DSM-IV criteria for ADHD: Some unsolved issues. ADHD Report , 3 , 1– 5 . First citation in articleGoogle Scholar

  • Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychological Bulletin , 121 , 65– 94 . First citation in articleCrossrefGoogle Scholar

  • Barkley, R. A. (1998). Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment. (2nd ed.). New York: Guilford . First citation in articleCrossrefGoogle Scholar

  • Barry, R. J. , Clarke, A. R. , Johnstone, S. J. (2003). A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clinical Neurophysiology , 114 , 171– 183 . First citation in articleCrossrefGoogle Scholar

  • Bedard, A.-C. , Ickowicz, A. , Logan, G. D. , Hogg-Johnson, S. , Schachar, R. , Tannock, R. (2003). Selective inhibition in children with attention-deficit hyperactivity disorder of and on stimulant medication. Journal of Abnormal Child Psychology , 31 , 315– 327 . First citation in articleCrossrefGoogle Scholar

  • Biederman, J. , Mick, E. , Faraone, S. V. (2000). Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type. American Journal of Psychiatry , 157 , 816– 818 . First citation in articleCrossrefGoogle Scholar

  • Biederman, J. , Mick, E. , Faraone, S.V. , Braaten, E. , Doyle, A. , Spencer, T. , Wilens, T. E. , Frazier, E. , Johnson, M. A. (2002). Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. American Journal of Psychiatry , 159 , 36– 42 . First citation in articleCrossrefGoogle Scholar

  • Burns, G. L. , Walsh, J. A. , Gomez, R. (2003). Convergent and discriminant validity of trait and source effects in ADHD-inattention and hyperactivity/impulsivity measures across a 3-month interval. Journal of Abnormal Child Psychology , 31 , 529– 541 . First citation in articleCrossrefGoogle Scholar

  • Burt, S. A. , Krueger, R. F. , McGue, M. , Iacono, W. G. (2001). Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: The importance of shared environment. Journal of Abnormal Psychology , 110 , 516– 525 . First citation in articleCrossrefGoogle Scholar

  • Carlson, C. L. , Mann, M. (2002). Sluggish cognitive tempo predicts a different pattern of impairment in the attention deficit hyperactivity disorder, predominantly inattentive type. Journal of Clinical Child and Adolescent Psychology , 31 , 123– 129 . First citation in articleCrossrefGoogle Scholar

  • Castellanos, F. X. , Lee, P. P. , Sharp, W. , Jeffries, N. O. , Greenstein, D. K. , Clasen, L. S. , Blumenthal, J. D. , James, R. S. , Ebens, C. L. , Walter, J. M. , Zijdenbos, A. , Evans, A. C. , Giedd, J. N. , Rapoport, J. L. (2002). Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Journal of American Medical Association , 288 , 1740– 1748 . First citation in articleCrossrefGoogle Scholar

  • Castellanos, F. X. , Tannock, R. (2002). Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nature Reviews Neuroscience , 3 , 617– 628 . First citation in articleCrossrefGoogle Scholar

  • Clarke, A. R. , Barry, R. J. , McCarthy, R. , Selikowitz, M. (2003). Hyperkinetic disorder in the ICD-10: EEG evidence for a definitional widening?. European Child and Adolescent Psychiatry , 12 , 92– 99 . First citation in articleCrossrefGoogle Scholar

  • Clarke, A. R. , Barry, R. , McCarthy, R. , Selikowitz, M. , Brown, C. (2002). EEG evidence for a new conceptualisation of attention deficit hyperactivity disorder. Clinical Neurophysiology , 113 , 1036– 1044 . First citation in articleCrossrefGoogle Scholar

  • Clarke, A. R. , Barry, R. J. , McCarthy, R. , Selikowitz, M. , Clarke, D. C. , Croft, R. J. (2003). EEG activity in girls with attention-deficit/hyperactivity disorder. Clinical Neurophysiology , 114 , 319– 328 . First citation in articleCrossrefGoogle Scholar

  • Clarke, A. R. , Barry, R. J. , McCarthy, R. , Selikowitz, M. , Croft, R. J. (2002). EEG differences between good and poor responders to methylphenidate in boys with the inattentive type of attention-deficit/hyperactivity disorder. Clinical Neurophysiology , 113 , 1191– 1198 . First citation in articleCrossrefGoogle Scholar

  • Collings, R. D. (2003). Differences between ADHD inattentive and combined types on the CPT. Journal of Psychopathology and Behavioral Assessment , 25 , 177– 189 . First citation in articleCrossrefGoogle Scholar

  • Crystal, D. S. , Ostrander, R. , Chen, R. S. , August, G. J. (2001). Multimethod assessment of psychopathology among DSM-IV subtypes of children with attention-deficit/hyperactivity disorder: self-, parent, and teacher reports. Journal of Abnormal Child Psychology , 29 , 189– 205 . First citation in articleCrossrefGoogle Scholar

  • Faraone, S. V. (2005). The scientific foundation for understanding attention-deficit/hyperactivity disorder as a valid psychiatric disorder. European Child and Adolescent Psychiatry , 14 , 1– 10 . First citation in articleCrossrefGoogle Scholar

  • Faraone, S.V. , Biederman, J. , Mick, E. , Williamson, S. , Wilens, T. , Spencer, T. , Weber, W. , Jetton, J. , Kraus, I. , Pert, J. , Zallen, B. (2000). Family study of girls with attention deficit hyperactivity disorder. American Journal of Psychiatry , 157 , 1077– 1083 . First citation in articleCrossrefGoogle Scholar

  • Faraone, S. V. , Perlis, R. H. , Doyle, A. E. , Smoller, J. W. , Goralnick, J. J. , Holmgren, M. A. , Sklar, P. (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry , 57 , 1293– 1300 . First citation in articleCrossrefGoogle Scholar

  • Gadow, K. D. , Drabick, D. A. G. , Loney, J. , Sprafkin, J. , Salisbury, H. , Azizian, A. , Schwartz, J. (2004). Comparison of ADHD symptom subtypes assource-specific syndromes. Journal of Child Psychology and Psychiatry , 45 , 1135– 1149 . First citation in articleCrossrefGoogle Scholar

  • Geurts, H. M. , Vert, S. , Oosterlaan, J. , Roeyers, H. , Sergeant, J. A. (2005). ADHD subtypes: do they differ in their executive functioning profile?. Archives of Clinical Neuropsychology , 4 , 457– 477 . First citation in articleCrossrefGoogle Scholar

  • Gillberg, C. , Gillberg, C. , Rasmussen, P. , Kadesjö, B. , Söderström, H. , Råstam, M. , Johnson, M. , Rothenberger, A. , Niklasson, L. (2004). Co-existing disorders in ADHD - implications for diagnosis and intervention. European Child and Adolescent Psychiatry , 13 (Suppl. 1) , 80– 92 . First citation in articleGoogle Scholar

  • Hampel, P. , Petermann, F. (2004). Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung. Kindheit und Entwicklung , 13 , 131– 136 . First citation in articleLinkGoogle Scholar

  • Hampel, P. , Petermann, F. , Mohr, B. , Bonkowski, M. , Mönter, C. (2004). Wirken sich unterschiedliche Verstärkerbedingungen bei Aufmerksamkeitsdefizit-/Hyperaktivitätsstörungen auf psychophysiologische Kennwerte aus?. Kindheit und Entwicklung , 13 , 148– 157 . First citation in articleLinkGoogle Scholar

  • Hartung, M. , Willcutt, E. G. , Lahey, B. B. , Pelham, W. E. , Loney, J. , Stein, M. A. , Keenan, K. (2002). Sex differences in young children who meet criteria for attention deficit hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology , 31 , 453– 464 . First citation in articleCrossrefGoogle Scholar

  • Herpertz, S. C. , Mueller, B. , Wenning, B. , Quanaibi, M. , Lichterferld, C. , Herpertz-Dahlmann, B. (2003). Autonomic response in boys with externalizing disorders. Journal of Neural Transmission , 110 , 1181– 1195 . First citation in articleCrossrefGoogle Scholar

  • Jensen, P. S. , Martin, D. , Cantwell, D. P. (1997). Comorbidity in ADHD: Implications for research, practice, and DSM-IV. Journal of the American Academy of Child and Adolescent Psychiatry , 36 , 1065– 1079 . First citation in articleCrossrefGoogle Scholar

  • Johansen, E. B. , Aase, H. , Meyer, A. , Sagvolden, T. (2002). Attention-deficit/hyperactivity disorder (ADHD) behaviour explained by dysfunctioning reinforcement and extinction processes. Behavioural Brain Research , 130 , 37– 45 . First citation in articleCrossrefGoogle Scholar

  • King, S. , Waschbusch, D. A. , Frankland, B. W. , Andrade, B. F. , Thurston, C. M. , McNutt, L. , Terrio, B. Northern Partners in Action for Child and Youth Services (2005). Taxonomic examination of ADHD and conduct problem comorbidity in elementary school children using cluster analyses. Journal of Psychopathology and Behavioral Assessment , 27 , 77– 88 . First citation in articleCrossrefGoogle Scholar

  • Koglin, U. , Petermann, F. (2004). Das Konzept der Inhibition in der Psychopathologie. Zeitschrift für Klinische Psychologie, Psychiatrie und Psychotherapie , 52 , 91– 117 . First citation in articleGoogle Scholar

  • Lahey, B. B. , Willcutt, E. G. (2002). Validity of the diagnosis and dimensions of attention deficit hyperactivity disorder. In P. S. Jensen & J. R. Cooper (Eds.), Attention Deficit Hyperactivity Disorder: State of science, best practices (pp. 1-23). Kingston: Civic Research Institute . First citation in articleGoogle Scholar

  • Levy, F. , Hay, D. A. , Bennett, K. S. , McStephen, M. (2005). Gender differences in ADHD subtype comorbidity. Journal of the American Academy of Child and Adolescent Psychiatry , 44 , 368– 376 . First citation in articleCrossrefGoogle Scholar

  • Lockwood, K. A. , Marcotte, C. A. , Stern, C. (2001). Differentiation of attention-deficit/hyperactivity disorder subtypes: Application of a neuropsychological model of attention. Journal of Clinical and Experimental Neuropsychology , 23 , 317– 330 . First citation in articleCrossrefGoogle Scholar

  • Lowe, N. , Kirley, A. , Hawi, Z. , Sham, P. , Wickham, H. , Kratochvil, C. J. , Smith, S. D. , Lee, S. Y. , Levy, F. , Kent, L. , Middle, F. , Rohde, L. A. , Roman, T. , Tahir, E. , Yazgan, Y. , Asherson, P. , Mill, J. , Thapar, A. , Payton, A. , Todd, R. D. , Stephens, T. , Ebstein, R. P. , Manor, I. , Barr, C. L. , Wigg, K. G. , Sinke, R. J. , Buitelaar, J. K. , Smalley, S. L. , Nelson, S. F. , Biederman, J. , Faraone, S. V. , Gill, M. (2004). Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. American Journal of Human Genetics , 74 , 348– 356 . First citation in articleCrossrefGoogle Scholar

  • Manuzza, S. , Klein, R. G. , Moulton, J. L. (2003). Young adult outcome of children with “situational“ hyperactivity: A prospective, controlled follow-up study. Journal of Abnormal Child Psychology , 30 , 191– 198 . First citation in articleCrossrefGoogle Scholar

  • Mehta, M. A. , Goodyer, I. M. , Sahakian, B. J. (2004). Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity. Journal of Child Psychology and Psychiatry , 45 , 293– 305 . First citation in articleCrossrefGoogle Scholar

  • Murphy, K. R. , Barkley, R. A. , Bush, T. (2001). Executive functioning and olfactory identification in young adults with attention deficit-hyperactivity disorder of Psychiatry. Neuropsychology , 15 , 211– 220 . First citation in articleCrossrefGoogle Scholar

  • Nadder, T. S. , Rutter, M. , Silberg, J. L. , Maes, H. H. , Eaves, L. J. (2002). Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatologies across informant and occasion measurement. Psychological Medicine , 32 , 39– 53 . First citation in articleCrossrefGoogle Scholar

  • Nigg, J. T. (2005). Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: The state of the field and salient challenges for the coming decade. Biological Psychiatry , 57 , 1424– 1435 . First citation in articleCrossrefGoogle Scholar

  • Nigg, J. T. , Willcutt, E. G. , Doyle, A. E. , Sonuga-Barke, E. J. S. (2005). Causal heterogeneity in attention-deficit/hyperactivity disorder: Do we need neuropsychologically impaired subtypes?. Biological Psychiatry , 57 , 1224– 1230 . First citation in articleCrossrefGoogle Scholar

  • Rasmussen, E. R. , Neuman, R. J. , Heath, A. C. , Levy, F. , Hay, D. A. , Todd, R. D. (2004). Familial clustering of latent class and DSM-IV defined attention-deficit/hyperactivity disorder (ADHD) subtypes. Journal of Child Psychology and Psychiatry , 45 , 589– 598 . First citation in articleCrossrefGoogle Scholar

  • Schachar, R. , Mota, V. L. , Logan, G. D. , Tannock, R. , Klim, P. (2000). Confirmation of an inhibitory control deficit in attention-deficit/hyperactivity disorder. Journal of Abnormal Child Psychology , 28 , 227– 235 . First citation in articleCrossrefGoogle Scholar

  • Schmitz, M. , Cadore, L. , Paczko, M. , Kipper, L. , Chaves, M. , Rohde, L. A. , Moura, C. , Knijnik, M. (2002). Neuropsychological performance in DSM-IV ADHD subtypes: An exploratory study with untreated adolescents. Canadian Journal of Psychiatry , 47 , 863– 869 . First citation in articleGoogle Scholar

  • Sciutto, M. J. , Nolfi, C. J. , Bluhm, C. (2004). Effects of child gender and symptom type on referrals for ADHD by elementary school teachers. Journal of Emotional and Behavioral Disorders , 12 , 247– 253 . First citation in articleCrossrefGoogle Scholar

  • Seeger, G. , Schloss, P. , Schmidt, M. H. (2001). Functional polymorphism within the promotor of the serotonin transporter gen eis associated with severe hyperkinetic disorder. Molecular Psychiatry , 6 , 235– 238 . First citation in articleCrossrefGoogle Scholar

  • Séguin, J. R. , Nagin, D. , Assaad, J.-M. , Tremblay, R. E. (2004). Cognitive-neuropsychological function in chronic physical aggression and hyperactivity. Journal of Abnormal Psychology , 113 , 603– 613 . First citation in articleCrossrefGoogle Scholar

  • Seidman, L. J. , Biederman, J. , Monuteaux, M. C. , Valera, E. , Doyle, A. E. , Faraone, S. V. (2005). Impact of gender and age on executive functioning: Do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?. Developmental Neuropsychology , 27 , 79– 105 . First citation in articleCrossrefGoogle Scholar

  • Sergeant, J. A. (2005). Modeling attention-deficit/hyperactivity disorder: A critical appraisal of the cognitive-energetic model. Biological Psychiatry , 57 , 1248– 1255 . First citation in articleCrossrefGoogle Scholar

  • Sobanski, E. , Alm, B. (2004). Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) bei Erwachsenen. Ein Überblick. Der Nervenarzt , 75 , 697– 716 . First citation in articleCrossrefGoogle Scholar

  • Strehl, U. , Leins, U. , Danzer, N. , Hinterberger, T. , Schlottke, P. F. (2004). EEG-Feedback für Kinder mit einer Aufmerksamkeitsdefizit- und Hyperaktivitätsstörung (ADHS). Kindheit und Entwicklung , 13 , 180– 189 . First citation in articleLinkGoogle Scholar

  • Sun, L. , Jin, Z. , Zang, Y. , Zeng, Y. , Liu, G. , Li, Y. , Seidman, L. J. , Faraone, S.V. , Wang, Y. (2005). Differences between attention-deficit disorder with and without hyperactivity: a 1H-magnetic resonance spectroscopy study. Brain and Development , 27 , 340– 344 . First citation in articleCrossrefGoogle Scholar

  • Todd, R. D. , Rasmussen, E. R. , Neumann, R. J. , Reich, W. , Hudziak, J. J. , Bucholz, K. K. , Madden, P. A. F. , Heath, A. C. (2001). Familiality and heritability of ADHD subtypes in a population sample of female twins. American Journal of Psychiatry , 158 , 1891– 1898 . First citation in articleCrossrefGoogle Scholar

  • Van Goozen, S. H. M. , Cohen-Kettenis, P. T. , Snoek, H. , Matthys, H. , Swaab-Barneveld, H. , van Engeland, H. (2004). Executive functioning in children: a comparison of hospitalised ODD and ODD/ADHD children and normal controls. Journal of Child Psychology and Psychiatry , 45 , 284– 292 . First citation in articleCrossrefGoogle Scholar

  • WHO (1994). Internationale Klassifikation psychischer Störungen. ICD-10, Kap V (F), Forschungskriterien. Bern: Huber . First citation in articleGoogle Scholar